Results 101 to 110 of about 72,586 (301)

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Change-Aware Scheduling for Effectively Updating Linked Open Data Caches

IEEE Access, 2018
The linked open data (LOD) cloud is a global information space with a wealth of structured facts, which are useful for a wide range of usage scenarios. The LOD cloud handles a large number of requests from applications consuming the data.
Usman Akhtar, Muhammad Asif Razzaq, Ubaid Ur Rehman, Muhammad Bilal Amin, Wajahat Ali Khan, Eui-Nam Huh, Sungyoung Lee   +6 more
doaj   +1 more source

Mapping spot blotch resistance genes in four barley populations [PDF]

, 2010
Bipolaris sorokiniana (teleomorph: Cochliobolus sativus) is the fungal pathogen responsible for spot blotch in barley (Hordeum vulgare L.) and occurs worldwide in warmer, humid growing conditions.
A Lehmensiek, A Lehmensiek, AK Joshi, Anke Lehmensiek, BJ Steffenson, BJ Steffenson, Emma Mace, GM Murray, Greg J. Platz, H Bilgic, H Bilgic, H Ghazvini, H Ghazvini, H Os Van, J Kumar, Jerome Franckowiak, Jessica Bovill, KF Manly, LC Emebiri, Mark W. Sutherland, MIE Arabi, MVG Müller, P Wenzl, P Wenzl, RE Voorrips, S Zhong, SI Meldrum, T Drader, T Kuldeep, Terry Usher, TG Fetch, TG Fetch, TS Grewal   +32 more
core   +2 more sources

Helix Alignment, Chevrons, and Edge Dislocations in Twist‐Bend Ferroelectric Nematics

Advanced Science, EarlyView.
The recently discovered twist‐bend ferroelectric nematic (NTBF) is the new member of the multiferroic family, representing a fluid with an oblique helicoidal (heliconical) periodic structure of spontaneous electric polarization. The work presents a thorough exploration of the material properties of this phase, how the periodic modulation of ...
Bijaya Basnet, Priyanka Kumari, Sathyanarayana Paladugu, Damian Pociecha, Jakub Karcz, Przemysław Kula, Nataša Vaupotič, Ewa Górecka, Oleg D Lavrentovich   +8 more
wiley   +1 more source

Effects of Health-Promoting Lifestyle on Late-Onset Depression in Older Adults: Mediating Effect of Meaning in Life and Interleukin-6 (IL-6)

Psychology Research and Behavior Management, 2023
Miao Zhu,1 Juan Zhao,1 Xiaoli Zhu,2 Qi Cheng,2 Shuyou Zhang,2 Lingming Kong2 1Psychiatry Department, The Oriental People’s Hospital of Xuzhou, Xuzhou, 221004, People’s Republic of China; 2Psychological Intervention Center, No.904 Hospital, Changzhou ...
Zhu M, Zhao J, Zhu X, Cheng Q, Zhang S, Kong L   +5 more
doaj  

Genetic and functional association of FAM5C with myocardial infarction

BMC Medical Genetics, 2008
Background We previously identified a 40 Mb region of linkage on chromosome 1q in our early onset coronary artery disease (CAD) genome-wide linkage scan (GENECARD) with modest evidence for linkage (n = 420, LOD 0.95).
Crossman David C, Seo David, Haynes Carol, Wang Ty, Lou Xuemei, Hale A Brent, Crosslin David R, Nelson Sarah, Gadson Shera, Doss Jennifer F, Shah Svati H, Connelly Jessica J, Mooser Vincent, Granger Christopher B, Jones Christopher JH, Kraus William E, Hauser Elizabeth R, Gregory Simon G   +17 more
doaj   +1 more source

Generating Natural Language from Linked Data:Unsupervised template extraction [PDF]

, 2013
We propose an architecture for generating natural language from Linked Data that automatically learns sentence templates and statistical document planning from parallel RDF datasets and text.
Duma, Daniel, Klein, Ewan
core   +1 more source

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source

Natural Variation of NAR5 Determines Nitrogenase Activity and the Yield in Soybean

Advanced Science, EarlyView.
This study identified NAR5, a gene encoding a subtilisin‐like protease, that regulates nitrogenase activity in soybean nodules. Overexpressing NAR5 delayed nodule senescence, enhancing nitrogenase activity, yield, and low‐nitrogen tolerance. The elite haplotype NAR5HapI‐1 linked to superior nitrogenase activity and greater seed weight has been ...
Chao Ma, Hanyu Zhao, Haojie Feng, Xulun Dong, Lin Chen, Mingliang Yang, Runyi Chen, Chengjun Lei, Chunyan Liu, Qingshan Chen, Dawei Xin, Jinhui Wang   +11 more
wiley   +1 more source

Application of QTL mapping for early selection on growth and latex yield traits in rubber breeding [PDF]

, 2011
The objective of this study was to apply the QTL mapping by Markers-Assisted Selection approach for early selection on growth and latex yield in rubber breeding.
Clément-Demange, André, Kasemsap, Poonpipope, Lekawipat, Napawan, Prapan, Kanlaya, Rattanawong, Ratchanee, Teerawattanasuk, Kanikar   +5 more
core