Results 81 to 90 of about 1,870,567 (303)

A genome-wide linkage scan identifies multiple quantitative trait loci for HDL-cholesterol levels in families with premature CAD and MI

Journal of Lipid Research, 2010
Plasma HDL cholesterol levels (HDL-C) are an independent predictor of coronary artery disease (CAD). We have completed a genome-wide linkage scan for HDL-C in a US cohort consisting of 388 multiplex families with premature CAD (GeneQuest).
Rong Yang, Lin Li, Sara Bretschger Seidelmann, Gong-Qing Shen, Sonia Sharma, Shaoqi Rao, Kalil G. Abdullah, Kenneth G. MacKinlay, Robert C. Elston, Qiuyun Chen, Eric J. Topol, Qing Kenneth Wang   +11 more
doaj   +1 more source

Pseudoautosomal region in schizophrenia: Linkage analysis of seven loci by sib-pair and lod-score methods

, 1994
International audienceIn a previous study, we reported a nonrandom segregation between schizophrenia and the pseudoautosomal locus DXYS14 in a sample of 33 sibships.
Clerget-Darpoux, Françoise, Mallet, Jacques, Bastard, Christian, d'Amato, Thierry, Petit, Christine, Campion, Dominique, Waksman, Gilles, Jay, Maurice, Laurent, Claudine, Martinez, Maria, Savoye, Christine, Gorwood, Philip, Babron, Marie Claude   +12 more
core   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

Advanced Science, EarlyView.
An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu, Yingyu Zhang, Xianwei Zhang, Mengxin Zhang, Fei Zhang, Jushan Sun, Yahui Yang, Kangbo Liu, Peng Wang, Shuying Luo, Wancun Zhang   +10 more
wiley   +1 more source

LOD-Plot showing genome wide linkage analysis in all three families.

, 2015
19 linkage regions with a maximum LOD-score of 1.62 were identified, which are illustrated by multipoint LOD scores above background.
Steffen Uebe (390051), André Rüffer (740629), Sven Dittrich (740628), Julia Moosmann (740627), Arif B. Ekici (146432), Okan Toka (740630)   +5 more
core   +1 more source

Hydrogel Phase Transition‐Driven Soft Gating Circumvents Debye Screening for Advanced Biosensing

Advanced Science, EarlyView.
A 3D soft gate utilizes a macroscopic hydrogel phase transition to effectively circumvent Debye screening in high‐salt environments. The intact matrix maximizes transmembrane ion flux via volumetric Donnan enrichment and superhydrophilicity. Target‐triggered network disassembly abolishes these effects, introducing a synergistic physical barrier.
Liu Shi, Zimeng Zhang, Bingheng Li, Yalei Gao, Ruirui Zhang, Zheying Mu, Jian Ni, Bing Bo, Genxi Li   +8 more
wiley   +1 more source

Identify changes of brain regional homogeneity in early and later adult onset patients with first-episode depression using resting-state fMRI.

PLoS ONE, 2017
ObjectivePrevious work exhibited different brain grey matter volume (GMV) changes between patients with early adult onset depression (EOD, age 18-29) and later adult onset depression (LOD, age 30-44) by using 30-year-old as the cut-off age.
Zonglin Shen, Linling Jiang, Shuran Yang, Jing Ye, Nan Dai, Xiaoyan Liu, Na Li, Jin Lu, Fang Liu, Yi Lu, Xuejin Sun, Yuqi Cheng, Xiufeng Xu   +12 more
doaj   +1 more source

The position of the highest LOD score on chromosome 11 and schematic physical maps of 11q13.4-11q14.1.

, 2013
(A) Position of the identified region on chromosome 11 and its relevant LOD score. The highest score was 1.901. (B) Schematic physical and genetic maps of the 11q13.4–11q14.1 chromosomal region show the location of DFNA11.
Qing Sang (277662), Duan Ma (40293), Huan Wang (109286), Li Jin (40265), Xukun Yan (277663), Huawei Li (277669), Lei Wang (6656), Qinghe Xing (277666), Lin He (102807), Qiaoli Li (277667), Xinzhi Zhao (277668), Xiang Fei (277665), Ruizhi Feng (277664)   +12 more
core   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

Whole genome scan LOD score plot for neointima (A) and media (B) area in the F2 mice, showing significance thresholds.

, 2015
Whole genome scan LOD score plot for neointima (A) and media (B) area in the F2 mice, showing significance thresholds.
Lars Bo Nielsen (316976), Jeong Shim (721565), Jacob F. Bentzon (721567), Caroline Östergren (721564), Jens Vinther Larsen (721566)   +4 more
core   +1 more source