Results 71 to 80 of about 1,870,567 (303)

The peak lod score by linkage analysis for clinical traits of AS disease, IBP and HLA-B27 on 22 chromosomes.

open access: yes, 2016
The peak lod score by linkage analysis for clinical traits of AS disease, IBP and HLA-B27 on 22 chromosomes.
Qiujing Wei (534852)   +12 more
core   +1 more source

Single‐Step Electrochemical Aptasensor for Melatonin Detection in Unprocessed Plasma

open access: yesAdvanced Science, EarlyView.
Melatonin is a well‐known biomarker with significant potential for clinical use in diagnosing circadian rhythm sleep disorders (CRSDs) and monitoring patients with documented circadian clock disruption. An electrochemical aptamer‐based biosensor (E‐aptasensor), employing an optimized population of melatonin aptamers, has been proposed as a solution for
Hamed Shieh   +6 more
wiley   +1 more source

Comparison of multipoint linkage analyses for quantitative traits in the CEPH data: parametric LOD scores, variance components LOD scores, and Bayes factors [PDF]

open access: yesBMC Proceedings, 2007
Abstract We performed multipoint linkage analyses with multiple programs and models for several gene expression traits in the Centre d'Etude du Polymorphisme Humain families. All analyses provided consistent results for both peak location and shape. Variance-components (VC) analysis gave wider peaks and Bayes factors gave fewer peaks.
Sung, Yun   +7 more
openaire   +2 more sources

LOD score plots for esterified and free cholesterol levels on chromosome 1.

open access: yes, 2013
The x-axis depicts the marker positions in centimorgans, and the y-axis depicts the LOD score. The microsatellite markers typed are listed below the x-axis, corresponding to their map locations on the chromosome.
Qian Wang (32718)   +6 more
core   +1 more source

A Monolithic Janus Hydrogel Pressure Sensor for Wearable Motion and Physiological Monitoring

open access: yesAdvanced Science, EarlyView.
This work reports a monolithic Janus hydrogel pressure sensor featuring integrated conductive PEDOT and insulating PEGDA layers. The fabricated device achieves a rapid response time, a wide operating range, and good cyclic durability. The sensor demonstrates robust performance in tracking dynamic human joint motions, offering a scalable strategy for ...
Syed Atif Ali   +7 more
wiley   +1 more source

Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onset

open access: yesNeuroImage: Clinical, 2016
Objective: Little is known about the pathological mechanism of early adult onset depression (EOD) and later adult onset depression (LOD). We seek to determine whether grey matter volume (GMV) change in EOD and LOD are different, which could also ...
Zonglin Shen   +11 more
doaj   +1 more source

The effect of ascertainment on penetrance estimates for rare variants: Implications for establishing pathogenicity and for genetic counselling.

open access: yesPLoS ONE, 2023
Next-generation sequencing has led to an explosion of genetic findings for many rare diseases. However, most of the variants identified are very rare and were also identified in small pedigrees, which creates challenges in terms of penetrance estimation ...
Andrew D Paterson   +2 more
doaj   +1 more source

Two-Point LOD Score Obtained from the Linkage Analysis between the BDA2 Locus and Chromosome 20p12.3 in the Pedigree.

open access: yes, 2014
Two-Point LOD Score Obtained from the Linkage Analysis between the BDA2 Locus and Chromosome 20p12.3 in the Pedigree.
Robert K. Valenzuela (186980)   +10 more
core   +1 more source

A Dual‐Mode In Situ EV‐miRNA Profiling Platform for Machine‐Learning‐Assisted Gastric Cancer Liquid Biopsy

open access: yesAdvanced Science, EarlyView.
An in situ dual‐mode platform integrates fusogenic liposomes with localized autocatalytic DNA circuits for plasma‐derived extracellular vesicle microRNA analysis. Following membrane fusion, target miRNAs trigger feedback‐assisted LECHA amplification inside intact vesicles, generating fluorescence and electrochemical outputs. Machine learning integrates
Wenbin Li   +15 more
wiley   +1 more source

Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X.

open access: yesPLoS Genetics, 2009
The prevalence of obesity (body mass index (BMI) > or =30 kg/m(2)) is higher in African Americans than in European Americans, even after adjustment for socioeconomic factors, suggesting that genetic factors may explain some of the difference. To identify
Ching-Yu Cheng   +36 more
doaj   +1 more source

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