Results 131 to 140 of about 1,870,567 (303)

CYP3A5 genetic variability influences sildenafil and metabolite in pulmonary hypertension

British Journal of Clinical Pharmacology, EarlyView.
Aim Interindividual variability in sildenafil response among pulmonary hypertension patients (PH) may be influenced by CYP3A5 polymorphisms. CYP3A5*3 allele reduces CYP3A5 activity and affects sildenafil metabolism. This study investigated the associations between CYP3A5 genotype and plasma concentrations of sildenafil and N‐desmethyl sildenafil, as ...
Pranisa Wongwien, Burabha Pussadhamma, Sirimas Kanjanawart, Thikhumporn Areesinpitak, Nontaya Nakkam, Chingching Foocharoen, Wichittra Tassaneeyakul, Suda Vannaprasaht   +7 more
wiley   +1 more source

QTLs for glomerular injury score in postmenopausal F2 (Dahl S x R) intercross female rats.

, 2013
QTL, quantitative trait locus; GIS, glomerular injury score; Chr, chromosome; % , the amount in % of total trait variance that would be explained by a QTL at these loci; Mbp, mega-base pair; LOD, logarithm of the odds score derived from the likelihood ...
Victoria L. M. Herrera (278588), Khristine A. Pasion (285363), Nelson Ruiz-Opazo (278587), Ann Marie Moran (278585)   +3 more
core   +1 more source

Feasibility Assessment of a Single‐pH Connected Polishing Train for Monoclonal Antibody Purification Using Mildly Acidic Protein A Elution and an Acidic‐Window Anion Exchange Membrane

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Monoclonal antibody downstream processing often requires multiple pH adjustments between Protein A capture and polishing steps. These adjustments increase process complexity and make direct unit‐operation connection more difficult. We evaluated a connected post‐capture polishing block operated at approximately pH 5.0 using mild‐pH Protein A ...
Takaki Aiso, Hiroshi Muto, Kyota Suzuki, Yumiko Masuda, Hirofumi Kakihara, Masashi Sonoyama   +5 more
wiley   +1 more source

Linkage Results (LOD-score vs. cM) for Spine Length Residuals.

, 2013
LOD-scores are illustrated for chromosomes 1–23 for spine length residuals. There is one highly suggestive peak (LOD  =  3.00) on chromosome 5.
Usha Chinappen-Horsley (38942), Ignac Fogelman (38944), Tim D. Spector (108990), Glen M. Blake (378035), Kourosh R. Ahmadi (206327), Bernet Kato (378037)   +5 more
core   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

The positions of the significant QTLs (LOD >4.5) identified for AUDPC, endpoint and mean disease score datasets following interval mapping, including linkage group, genetic and physical positions of the closest flanking markers, and associated LOD values and total phenotypic variance explained, along with the associated Kruskall-Wallis test statistic (K*) scores for the most significant marker in each dataset.

, 2019
The positions of the significant QTLs (LOD >4.5) identified for AUDPC, endpoint and mean disease score datasets following interval mapping, including linkage group, genetic and physical positions of the closest flanking markers, and associated LOD values
Nada Šurbanovski (427477), Daniel J. Sargent (6993869), Muath Alsheikh (798906), Matteo Buti (3454244), May Bente Brurberg (7406051), Jahn Davik (798905), Matthew P. Kent (7406054)   +6 more
core   +1 more source

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

eQTLs overlapping the 1.5 LOD drop region of the PR QTL.

, 2013
Transcripts with a significant linkage overlapping the 1.5 LOD drop region of the PR QTL are listed with their genomic location (build NCBIM37), specific LOD score, marker with the highest LOD score, Spearmans correlation to PR (Rho and uncorrected p ...
Elisabeth M. Lodder (295429), Douglas A. Marchuk (242744), Annalisa Milano (295433), Geoffrey S. Pitt (107104), Connie R. Bezzina (215605), Michael W. T. Tanck (295438), Carol Ann Remme (295436), Perry D. Moerland (201141), Hao Tang (44155), Brendon P. Scicluna (295431), Albert Y. Sun (107100)   +10 more
core   +1 more source

Hyperledger Fabric for the (digitalized) lifecycle of construction products: Applied review on fastening technology

Civil Engineering Design, Volume 7, Issue 1, Page 9-22, March 2025.
Abstract Blockchain technology is a digital decentralized data ledger recording transactions in an encrypted format. Its implementation can potentially hold significant advantages for the built environment, particularly in manufacturing and building product usage aligned with Building Information Modeling (BIM). This paradigm shift toward decentralized
Aileen Pfeil, Dimosthenis Kifokeris, Panagiotis Spyridis   +2 more
wiley   +1 more source

Descriptive statistics, including the LOD score, the position, 95% CI, PVE (%), the associated P-value of each QTL linked to every phenotype related to bacteria counts trait (LOD, Log₁₀ of the odd ratio; 95% CI, 95% confidence interval; PVE, percent variance explained) [23].

, 2014
Descriptive statistics, including the LOD score, the position, 95% CI, PVE (%), the associated P-value of each QTL linked to every phenotype related to bacteria counts trait (LOD, Log10 of the odd ratio; 95% CI, 95% confidence interval; PVE, percent ...
Sébastien Boutin (212040), Céline Audet (501767), Nicolas Derome (2201653), Christopher Sauvage (605478), Louis Bernatchez (33427)   +4 more
core   +1 more source