Results 141 to 150 of about 33,686 (303)
An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity
Advanced Science, EarlyView.The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao +9 more
wiley +1 more source
Advanced Science, EarlyView.Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib +8 more
wiley +1 more source
American Journal of Hematology, EarlyView.ABSTRACT Hypomethylating agents (HMA) and allogeneic hematopoietic stem cell transplantation (alloHSCT) have both demonstrated remissions in VEXAS; however, comparative data is lacking. We conducted a multicenter, retrospective analysis of 66 patients diagnosed with VEXAS syndrome treated with HMA (n = 35) or alloHSCT (n = 31). Baseline characteristics
Saubia Fathima +48 more
wiley +1 more source
Average LOD profiles on chromosome 1 across 1000 simulation runs for the linked QTL model.
, 2015 (A) H2 = 0.1. (B) H2 = 0.5. (C) H2 = 0.8. LOD scores on other chromosomes were not shown because no QTL was defined there. LOD score was close to zero on chromosomes 2 to 6.
Shanshan Li (114847) +2 more
core +1 more source
American Journal of Industrial Medicine, EarlyView.ABSTRACT Introduction Firefighters may experience occupational exposure to per‐ and polyfluoroalkyl substances (PFAS). Volunteer firefighters make up 65% of the US fire service, but their serum PFAS profiles have not been well characterized. This study aims to (1) describe PFAS serum profiles among US volunteer firefighters from 9 states enrolled in ...
Katherine A. Lubina +16 more
wiley +1 more source
Two significant and two suggestive LOD scores on Hsa12, Hsa15, Hsa1, and Hsa19.
, 2012 LOD scores of genome-wide linkage analyses using the CEPH-HapMap family-cohort of three generations are plotted for all autosomal chromosomes (in blue). The blue line shows the maximal LOD score within a window size of 10 kb.
Holger Prokisch (26590) +15 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.This study established a closed‐tube LAMP‐LFD assay for detecting Rodentibacter heylii and Rodentibacter pneumotropicus. The method exhibited high sensitivity (detection limits of 10−5 ng/μL for R. heylii and 10−4 ng/μL for R. pneumotropicus), high specificity, reliable performance with clinical samples, and effective validation in experimental ...
Huiqiong Yan +17 more
wiley +1 more source
QTLs for glomerular injury score in postmenopausal F2 (Dahl S x R) intercross female rats.
, 2013 QTL, quantitative trait locus; GIS, glomerular injury score; Chr, chromosome; % , the amount in % of total trait variance that would be explained by a QTL at these loci; Mbp, mega-base pair; LOD, logarithm of the odds score derived from the likelihood ...
Victoria L. M. Herrera (278588) +3 more
core +1 more source
Annals of Neurology, EarlyView.Objective Multiple sclerosis (MS) is a chronic autoimmune disease where B cells play a central pathogenic role. Cladribine, an oral therapy, provides durable benefits by reshaping lymphocyte populations, yet its specific long‐term impact on distinct B‐cell subsets is not fully understood.
Marta Pirronello +20 more
wiley +1 more source
Gene mapping using linkage analysis
The Turkish Journal of Pediatrics, 1991 Linkage analysis is a recombinant technology used for gene mapping. If two genetic loci segregate together in a pedigree more often than by random chance, they are said to be linked, that is they lie close on the same chromosome.
O Sanal, T Foroud, R A Gatti
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