Results 261 to 270 of about 72,001 (287)

Quantification of type I error probabilities for heterogeneity LOD scores

Genetic Epidemiology, 2002
AbstractLocus heterogeneity is a major confounding factor in linkage analysis. When no prior knowledge of linkage exists, and one aims to detect linkage and heterogeneity simultaneously, classical distribution theory of log‐likelihood ratios does not hold.
Paula C, Abreu, Susan E, Hodge, David A, Greenberg   +2 more
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On the lod score method in linkage analysis

Annals of Human Genetics, 1984
SummaryGenetic epidemiology deals with the interaction of environmental and genetic determinants in common diseases. Linkage analysis is an important branch of this field. The current practice of claiming linkage between two genetic loci when the maximum lod score z(θ) exceeds 3 has not received theoretical justification, whether considered as a ...
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Efficiency of lod scores for representing multiple locus linkage data

Genetic Epidemiology, 1985
AbstractThe problem of compact, fully efficient representation of multilocus data has not yet been solved. Lod scores can be used to map multilocus data, but because of certain statistical problems, this method loses some information. However, simulation studies show that for distances less than 10 or 20 cMo, where there is little danger of huge ...
C. J. Maclean, N. E. Morton, R. Lew, D. C. Rao   +3 more
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Interpretation of LOD scores with a set of marker loci

Genetic Epidemiology, 1984
AbstractThe problem discussed is that of interpreting LOD scores when multiple markers are tested for linkage with a particular disease locus. Provided the tests are based on independent segregations, both the maximum and the average LOD can be translated into a score that would have the same significance level were it the result of a single test.
E. A. Thompson, Walter E. Nance
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Inferring mode of inheritance by comparison of lod scores

American Journal of Medical Genetics, 1989
AbstractOne usually must assume a mode of inheritance when using lod scores for linkage analysis. In this study, we asked the question, “If one assumed mode of inheritance in a linkage analysis gives a higher lod score than another, does that indicate that the mode of inheritance that led to the higher lod score is more ‘correct’ than the other?”We ...
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Extension of the lod score: the mod score.

Advances in genetics, 2001
In 1955 Morton proposed the lod score method both for testing linkage between loci and for estimating the recombination fraction between them. If a disease is controlled by a gene at one of these loci, the lod score computation requires the prior specification of an underlying model that assigns the probabilities of genotypes from the observed ...
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Lod score Redivivus

Nature, 1988
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Asymptotic distribution of the lod score for familial data.

Proceedings of the National Science Council, Republic of China. Part B, Life sciences, 1989
Using a linkage model with mixed parental mating types between a trait locus and a marker locus the asymptotic null distribution of the statistic U = 2ln(10)Z(theta) was stimulated and compared to the chi square type distribution function 1/2 + 1/2 Pr [chi 2(1) less than mu].
J J, Tai, C L, Chen
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LOD Score

2006
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Some lod scores concerning chromosome 1

Cytogenetic and Genome Research, 1976
J, Mohr, H, Eiberg, G, Skude
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