Results 11 to 20 of about 1,188 (111)

Evaluation of knowledge, attitude and practices towards loiasis in the rural community of Sindara, in central African Gabon

PLoS Neglected Tropical Diseases
BackgroundMore than 20 million people are infected with L. loa, and around 40 million live in high or intermediate-risk areas in West- and Central Africa.
Michael Ramharter, Saskia Dede Davi
exaly   +2 more sources

Impact of repeated annual community directed treatment with ivermectin on loiasis parasitological indicators in Cameroon: Implications for onchocerciasis and lymphatic filariasis elimination in areas co-endemic with Loa loa in Africa [PDF]

PLoS Neglected Tropical Diseases, 2018
BACKGROUND:Loiasis is a filarial infection endemic in the rainforest zone of west and central Africa particularly in Cameroon, Gabon, Republic of Congo, and Democratic Republic of the Congo.
Moses Bockarie, Benjamin G Koudou, Abdel Jelil Njouendou   +2 more
exaly   +2 more sources

Evaluation of a novel biplex rapid diagnostic test for antibody responses to Loa loa and Onchocerca volvulus infections. [PDF]

PLoS Neglected Tropical Diseases
BackgroundEndemic to Central Africa, loiasis, caused by the vector-borne worm Loa loa, affects approximately 10 million individuals. Clinical manifestations include transient angioedema (Calabar swellings), migration of the adult worm under the eye ...
Jérémy T Campillo, Marco A Biamonte, Marlhand C Hemilembolo, François Missamou, Michel Boussinesq, Sébastien D S Pion, Cédric B Chesnais   +6 more
doaj   +2 more sources

Design and analysis of randomized clinical trials for onchocerciasis, loiasis and mansonellosis: A systematic review. [PDF]

PLoS Neglected Tropical Diseases
BackgroundThe design and analysis of randomized clinical trials (RCTs) in filarial diseases such as onchocerciasis, loiasis, and mansonellosis pose unique statistical challenges, including skewed endpoints and limited sample sizes. This systematic review
Fabrice Lotola Mougeni, Marta Bofill Roig, Marc P Hübner, Ute Klarmann-Schulz, Benjamin Lenz, Sabine Specht, Martin Posch, Sonja Zehetmayer   +7 more
doaj   +2 more sources

Performance of two serodiagnostic tests for loiasis in a Non-Endemic area

PLoS Neglected Tropical Diseases, 2020
Loiasis, caused by the filarial nematode Loa loa, is endemic in Central and West Africa where about 10 million people are infected. There is a scarcity of convenient, commercial diagnostics for L. loa.
Michel Boussinesq, Paola Rodari, Zeno Bisoffi   +2 more
exaly   +2 more sources

A novel antigen biomarker for detection of high-level of Loa loa microfilaremia. [PDF]

PLoS Neglected Tropical Diseases
BackgroundLoiasis is a disease caused by the nematode Loa loa. Serious adverse events sometimes occur in people with heavy L. loa microfilaremia after ivermectin treatment. In regions of Central Africa where loiasis is endemic, this significantly impedes
Sarah E Greene, Yuefang Huang, Kerstin Fischer, Bruce A Rosa, John Martin, Makedonka Mitreva, Devyn Yates, Samuel Wanji, Joseph Kamgno, Philip J Budge, Gary J Weil, Peter U Fischer   +11 more
doaj   +2 more sources

Analysis of diagnostic test outcomes in a large loiasis cohort from an endemic region: Serological tests are often false negative in hyper-microfilaremic infections

PLoS Neglected Tropical Diseases
BackgroundThe parasitic disease loiasis is associated with significant morbidity and mortality. Individuals with hyper-microfilaremia (greater than 20,000 microfilariae per mL of blood) may suffer from serious treatment-related or spontaneous adverse ...
Luzia Veletzky, Jennifer Hergeth, Pierre Blaise Matsiegui   +2 more
exaly   +3 more sources

Programmed cell death pathways as targets for developing antifilarial drugs: Lessons from the recent findings

Journal of Cellular and Molecular Medicine, Volume 27, Issue 19, Page 2819-2840, October 2023., 2023
Abstract More than half a century has passed since the introduction of the National Filariasis Control Program; however, as of 2023, lymphatic filariasis (LF) still prevails globally, particularly in the tropical and subtropical regions, posing a substantial challenge to the objective of worldwide elimination.
Nabarun Chandra Das, Pritha Chakraborty, Samapika Nandy, Abhijit Dey, Tabarak Malik, Suprabhat Mukherjee   +5 more
wiley   +1 more source

The Impact of Mass Drug Administration on Lymphatic Filariasis

Journal of Tropical Medicine, Volume 2022, Issue 1, 2022., 2022
Mass drug administration (MDA) has made a significant impact on the control of lymphatic filariasis (LF) since the establishment of the Global Programme to Eliminate Lymphatic Filariasis. However, its implementation is associated with several challenges, hampering interruption of parasite transmission and LF elimination in endemic areas.
Isaac Frimpong Aboagye, Yvonne Abena Afadua Addison, Pedro P. Chieffi   +2 more
wiley   +1 more source

An Adult Loa loa Worm in the Upper Eyelid: An Atypical Presentation of Loiasis in the United States

Case Reports in Ophthalmological Medicine, Volume 2021, Issue 1, 2021., 2021
Purpose. To report a case of ocular involvement of Loa loa parasite. Observations. We present a rare case report of a Loiasis diagnosed in the United States from a patient presenting with subcutaneous migration of an adult worm within an eyelid who was found to have systemic disease with microfilaria in his blood.
Linnet Rodriguez, Julia Michelle White, Nikisha Q. Richards, Alan X. You, Natario L. Couser, Hiroshi Eguchi   +5 more
wiley   +1 more source