Results 1 to 10 of about 1,154 (118)

Binding of Selected Ligands to Human Protein Disulfide Isomerase and Microsomal Triglyceride Transfer Protein Complex and the Associated Conformational Changes: A Computational Molecular Modelling Study [PDF]

ChemistryOpen
Human protein disulfide isomerase (PDI) is a multifunctional protein, and also serves as the β subunit of the human microsomal triglyceride transfer protein (MTP) complex, a lipid transfer machinery.
Yong Xiao Yang, Peng Li, Bao Ting Zhu
doaj   +3 more sources

RFWD3 Reprograms Nucleotide Metabolism Through PHGDH to Induce Chemoresistance In Osteosarcoma [PDF]

Advanced Science
Chemoresistance represents a major challenge for osteosarcoma treatment. Despite the improved knowledge of cancer biology, the core determinants of cisplatin (DDP) resistance in osteosarcoma remain unclear and deserve further exploration.
Wenchao Zhang, Chi Yin, Lin Qi, Zhongyue Liu, Ruiling Xu, Chao Tu, Zhihong Li   +6 more
doaj   +3 more sources

Discovery of Lomitapide as a Novel Mast Cell Regulatory Agent Through Chemical Library Screening. [PDF]

Eur J Immunol
Chemical library screening identified lomitapide as a novel mast cell (MC) regulatory agent. Lomitapide selectively inhibits IgE/Ag‐ or phorbol 12‐myristate 13‐acetate (PMA)/ionomycin‐mediated MC degranulation by altering plasma membrane dynamics, including endocytosis and membrane fusion. ABSTRACT Allergic diseases are a global health concern, and new
Mamorita S, Furukawa A, Nagata Y, Suzuki R.   +3 more
europepmc   +2 more sources

Adaptation to cystine limitation stress confers a targetable lipid metabolism vulnerability in pancreatic ductal adenocarcinoma [PDF]

Nature Communications
Cystine/cysteine is critical for antioxidant response and sulfur metabolism in cancer cells and is one of the most depleted amino acids in the microenvironment of pancreatic ductal adenocarcinoma (PDAC).
Yunzhan Li, Zekun Li, Qin Li, Dongxiao Sun, Bo Ni, Mingjun Tan, Ashley E. Shay, Min Wang, Chenyang Meng, Guangcong Shen, Boyang Fu, Yueying Shan, Shiqi Zhang, Rifah Rownak Tanshee, Tianxing Zhou, Yongjie Xie, Kun-Ming Chen, Bin Qiao, Yunkun Dang, Scot R. Kimball, Guanshi Zhang, Girish H. Rajacharya, Pankaj K. Singh, Xiuchao Wang, Jihui Hao, Shengyu Yang   +25 more
doaj   +2 more sources

Lomitapide modifies high-density lipoprotein function in homozygous familial hypercholesterolaemia [PDF]

European Journal of Medical Research
Background Lomitapide reduces plasma low-density lipoprotein cholesterol (LDL-C) and is approved for the treatment of homozygous familial hypercholesterolemia (HoFH).
Anouar Hafiane, Annalisa Ronca, Matteo Incerti, Alessandra Rossi, Matteo Manfredini, Elda Favari   +5 more
doaj   +2 more sources

Blueberries Reduce Palm Oil-Induced Metabolic Endotoxemia in an In Vitro Human Intestinal-Immune Cell Model. [PDF]

Mol Nutr Food Res
Digested palm oil and LPS treatment on intestinal Caco‐2 cells results in palm oil‐induced LPS translocation across the intestinal cell monolayer and nuclear factor kappa B (NF‐κB) activation of basolateral macrophages. Interestingly, digested whole berries reduce the palm oil + LPS‐mediated NF‐κB activation in macrophages.
Casademont-Roca A, Tomassen MMM, Kersten S, Steegenga WT, Hooiveld GJ, Mes JJ.   +5 more
europepmc   +2 more sources

New insights into the management of homozygous familial hypercholesterolemia patients treated with lomitapide: a single-center experience [PDF]

Frontiers in Endocrinology
Familial hypercholesterolemia (FH) is a genetic disease, usually with onset during childhood, characterized by elevated blood LDL cholesterol levels and potentially associated with severe cardiovascular complications. Concerning mutated genes in FH, such
Gabriella Iannuzzo, Ilenia Lorenza Calcaterra, Marco Gentile, Claudia Stanzione, Francesca de Ruberto, Maria Donata di Taranto, Giovanna Cardiero, Giuliana Fortunato, Matteo Di Minno   +8 more
doaj   +2 more sources

Heat stress enhances VLDL secretion in chicken ovarian follicles to potentiate its impact on follicular cell survival and maturation [PDF]

Poultry Science
Chicken ovaries possess the machinery of VLDL production in response to heat stress (HS). The study sought to define the role of VLDL secretion by hierarchical follicles along their development under HS.
Petnamnueng Dettipponpong, Mei-Ying Sin, Yu-Hui Chen, Chuen-Yu Cheng, San-Yuan Huang, Ling-Chu Chang, Shuen-Ei Chen   +6 more
doaj   +2 more sources

Lomitapide repurposing for treatment of malignancies: A promising direction [PDF]

Heliyon
The development of novel drugs from basic science to clinical practice requires several years, much effort, and cost. Drug repurposing can promote the utilization of clinical drugs in cancer therapy.
Hua-Tao Wu, Bing-Xuan Wu, Ze-Xuan Fang, Zheng Wu, Yan-Yu Hou, Yu Deng, Yu-Kun Cui, Jing Liu   +7 more
doaj   +2 more sources

Long-term effectiveness and safety of lomitapide in patients with homozygous familial hypercholesterolemia: an observational case series [PDF]

Orphanet Journal of Rare Diseases
Background We assessed long-term real-world effectiveness and safety of lomitapide in patients with homozygous familial hypercholesterolemia (HoFH). Methods Retrospective case series of six patients with HoFH treated with lomitapide in an Italian clinic.
Patrizia Suppressa, Chiara Coppola, Veronica Cocco, Sallyann O’Brien   +3 more
doaj   +2 more sources