Lomitapide repurposing for treatment of malignancies: A promising direction
HeliyonThe development of novel drugs from basic science to clinical practice requires several years, much effort, and cost. Drug repurposing can promote the utilization of clinical drugs in cancer therapy.
Hua-Tao Wu +7 more
doaj +2 more sources
Target achievement and cardiovascular event rates with Lomitapide in homozygous Familial Hypercholesterolaemia [PDF]
Orphanet Journal of Rare Diseases, 2018 Background Homozygous familial hypercholesterolaemia (HoFH) is characterized by a markedly increased risk of premature cardiovascular (CV) events and cardiac death.
Dirk J. Blom +3 more
doaj +2 more sources
Sex-related differences in response to lomitapide in HoFH: A subanalysis of the Pan-European Lomitapide retrospective observational study. [PDF]
AtherosclerosisBACKGROUND AND AIMS Homozygous familial hypercholesterolemia (HoFH) is a hereditary lipid metabolism disorder characterized by severe elevation of low-density lipoprotein cholesterol (LDL-C) and heightened risk of premature atherosclerotic cardiovascular
C. Pavanello +10 more
semanticscholar +3 more sources
Oligogenic Familial Hypercholesterolemia Treated by Combination Therapy of Statin, Ezetimibe, PCSK9 Inhibitor, and Lomitapide. [PDF]
Intern MedWe encountered a 40-year-old man diagnosed with homozygous familial hypercholesterolemia (FH) based on clinical findings. The initial low-density lipoprotein (LDL)-cholesterol level was 393 mg/dL.
Kojima N, Tada H, Takamura M.
europepmc +2 more sources
Heat stress enhances VLDL secretion in chicken ovarian follicles to potentiate its impact on follicular cell survival and maturation [PDF]
Poultry ScienceChicken ovaries possess the machinery of VLDL production in response to heat stress (HS). The study sought to define the role of VLDL secretion by hierarchical follicles along their development under HS.
Petnamnueng Dettipponpong +6 more
doaj +2 more sources
MicroRNA-30c analog C2 decreases plasma cholesterol and atherosclerosis without causing liver injury in preclinical studies [PDF]
Nature CommunicationsHigh plasma cholesterol levels substantially contribute to cardiovascular disease. Hepatic delivery of the microRNA-30c analog C2 decreased plasma cholesterol in apoB-containing lipoproteins in hypercholesterolemic C57BL/6 mice, in African green monkeys ...
Binu Prakash +14 more
doaj +2 more sources
Lapatinib, Nilotinib and Lomitapide Inhibit Haemozoin Formation in Malaria Parasites
Molecules, 2020 With the continued loss of antimalarials to resistance, drug repositioning may have a role in maximising efficiency and accelerating the discovery of new antimalarial drugs.
Ana Carolina C. de Sousa +3 more
doaj +2 more sources
A Comprehensive Review of the Latest Approaches to Managing Hypercholesterolemia: A Comparative Analysis of Conventional and Novel Treatments: Part II [PDF]
PharmaceuticalsCardiovascular disease (CVD) remains the leading cause of mortality worldwide, with hypercholesterolemia identified as a major, but modifiable risk factor. This review serves as the second part of a comprehensive analysis of dyslipidemia management.
Narcisa Jianu +9 more
doaj +2 more sources
Hepatic Nuclear Factor Erythroid 2 Related Factor 1 Activity Promotes Host Defense in Endotoxemia and Bacterial SepsisSummary [PDF]
Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: Sepsis and endotoxemia cause mortality by inducing organ dysfunction and damage. Liver defends against such insults by mediating metabolic adaptations that promote stress and damage control. The mechanisms underlying liver defenses
Michael J. Trites +5 more
doaj +2 more sources
SRSF7 promotes pulmonary fibrosis through regulating PKM alternative splicing in lung fibroblasts [PDF]
Acta Pharmaceutica Sinica BIdiopathic pulmonary fibrosis (IPF), a chronic interstitial lung disease, is characterized by aberrant wound healing, excessive scarring and the formation of myofibroblastic foci.
Tongzhu Jin +20 more
doaj +2 more sources