MedComm – OncologyOsimertinib resistance remains a significant challenge in the treatment of non‐small cell lung cancer (NSCLC). N6‐methyladenosine (m6A) modifications are closely linked to various mechanisms of anticancer resistance and autophagy, offering new avenues ...
Xiaohui Du +7 more
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Lomitapide: A Medication Use Evaluation and a Formulary Perspective [PDF]
Global Journal on Quality and Safety in HealthcareIntroduction Lomitapide is approved for lowering low-density lipoprotein cholesterol (LDL-C) in homozygous familial hypercholesterolemia, which is a rare genetic disorder.
Laila Carolina Abu Esba, Hani Alharbi
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Cell Death Discovery, 2023 Palmitoylation of proteins plays important roles in various physiological processes, such as cell proliferation, inflammation, cell differentiation etc. However, inhibition of protein palmitoylation has led to few new drugs to date.
Yumeng Wang +7 more
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Letter in Response to “Lomitapide: A Medication Use Evaluation and a Formulary Perspective” by Esba and Alharbi [PDF]
Global Journal on Quality and Safety in HealthcareDirk J. Blom
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A Comprehensive Review of the Latest Approaches to Managing Hypercholesterolemia: A Comparative Analysis of Conventional and Novel Treatments: Part II [PDF]
PharmaceuticalsCardiovascular disease (CVD) remains the leading cause of mortality worldwide, with hypercholesterolemia identified as a major, but modifiable risk factor. This review serves as the second part of a comprehensive analysis of dyslipidemia management.
Narcisa Jianu +9 more
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Hepatic Nuclear Factor Erythroid 2 Related Factor 1 Activity Promotes Host Defense in Endotoxemia and Bacterial SepsisSummary [PDF]
Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: Sepsis and endotoxemia cause mortality by inducing organ dysfunction and damage. Liver defends against such insults by mediating metabolic adaptations that promote stress and damage control. The mechanisms underlying liver defenses
Michael J. Trites +5 more
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SRSF7 promotes pulmonary fibrosis through regulating PKM alternative splicing in lung fibroblasts [PDF]
Acta Pharmaceutica Sinica BIdiopathic pulmonary fibrosis (IPF), a chronic interstitial lung disease, is characterized by aberrant wound healing, excessive scarring and the formation of myofibroblastic foci.
Tongzhu Jin +20 more
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X-linked ubiquitin-specific peptidase 11 (USP11) increases susceptibility to Cushing’s disease in women [PDF]
Acta Neuropathologica CommunicationsThe incidence of pituitary adrenocorticotropic hormone (ACTH)-secreting PitNETs, commonly known as ACTH PitNETs, is significantly higher in females; however, the underlying causes for this gender disparity remain unclear.
Tao Zhang +8 more
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In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy [PDF]
Scientific ReportsDue to considerable global prevalence and high recurrence rate, the pursuit of effective new medication for epilepsy treatment remains an urgent and significant challenge. Drug repurposing emerges as a cost-effective and efficient strategy to combat this
Xiaoying Lv +5 more
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Lomitapide, a Microsomal Triglyceride Transfer Protein Inhibitor, in Homozygous Familial Hypercholesterolemia: A Systematic Review and Meta-Analysis of Efficacy and Safety. [PDF]
Cardiovasc Drugs TherHomozygous Familial Hypercholesterolemia (HoFH) is a rare and life-threatening genetic disorder characterized by elevated low-density lipoprotein cholesterol (LDL-C) and early-onset atherosclerotic cardiovascular disease.
Nasser M +8 more
europepmc +2 more sources