Results 91 to 100 of about 8,328,477 (294)

Gene Fusion Detection in Long-Read Transcriptome Datasets from Multiple Cancer Cell Lines

Frontiers in Bioscience-Landmark
Background: Fusion genes are important biomarkers in cancer research because their expression can produce abnormal proteins with oncogenic properties.
Keigo Masuda, Yoshiaki Sota, Hideo Matsuda   +2 more
doaj   +1 more source

Long-read-based human genomic structural variation detection with cuteSV

, 2019
Long-read sequencing enables the comprehensive discovery of structural variations (SVs). However, it is still non-trivial to achieve high sensitivity and performance simultaneously due to the complex SV signatures implied by noisy long reads.
Jiang, Tao, Jiang, Tao (8215998)
core   +1 more source

Expanding an expanded genome: long-read sequencing of Trypanosoma cruzi [PDF]

, 2018
Supporting data of the article 'Expanding an expanded genome: long-read sequencing of Trypanosoma cruzi,' as published in Microbial Genomics. DOI: 10.1099/mgen.0.000177
Fernando Alvarez-Valin, Gastón Rijo (5027948), Fernando Alvarez-Valin (5027954), Luisa Berná, Carlos Robello, Matias Rodriguez, Adriana Parodi-Talice, María Laura Chiribao (840672), Adriana Parodi-Talice (5027945), Sebastián Pita, Gastón Rijo, Luisa Berná (4288387), Sebastián Pita (3600737), Matías Rodríguez (5027951), Carlos Robello (238938), María Laura Chiribao, Parodi-Tálice, Adriana Magdalena, Berná, Luisa, Robello Porto, Carlos, Álvarez-Valín, Fernando, Chiribao, María Laura, Rodríguez, Matías A, Pita Mimbacas, Sebastián, Rijo, Gastón   +23 more
core   +1 more source

Long-read single-cell sequencing using scCOLOR-seq

, 2023
Single-cell sequencing allows for the measurement of sequence information from individual cells with next-generation sequencing (NGS). However, its application to third-generation sequencing platforms such as Oxford Nanopore has been challenging because ...
Adam P. Cribbs, Martin Philpott, Udo Oppermann   +2 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Table_2_Oxford nanopore long-read sequencing enables the generation of complete bacterial and plasmid genomes without short-read sequencing.DOCX

, 2023
IntroductionGenome-based analysis is crucial in monitoring antibiotic-resistant bacteria (ARB)and antibiotic-resistance genes (ARGs). Short-read sequencing is typically used to obtain incomplete draft genomes, while long-read sequencing can obtain ...
Zhenpeng Li (553533), Biao Kan, Ming Luo, Ming Luo (13872), Jialiang Xu (1424821), Xin Lu, Xin Lu (24821), Bo Pang (164741), Wenxuan Zhao (4615180), Bo Pang, Yao Peng, Wenxuan Zhao, Zhenpeng Li, Yao Peng (1928524), Jialiang Xu, Wei Zeng, Wei Zeng (126658), Biao Kan (107255)   +17 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Long-Read Metagenomic Sequencing

Abstract This chapter describes the preparation of metagenomic DNA samples to produce long-read Oxford Nanopore-compatible libraries for shotgun whole-genome sequencing (WGS). This is of value for projects needing to assemble novel unculturable bacterial species and where higher resolution is required.
Dave Baker, Cara-Jane Moss
openaire   +1 more source