Alteration of the gut microbiome and correlated metabolism in a rat model of long-term depression [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 ObjectiveThis study aims to investigate the composition and function of the gut microbiome in long-term depression using an 8-week chronic unpredictable mild stress (CUMS) rat model.Materials and methodsAnimals were sacrificed after either 4 weeks or 8 ...
Yubo Li +12 more
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EMDR as a treatment for long‐term depression: A feasibility study [PDF]
Psychology and psychotherapy, 2017 Objective Current treatments for long‐term depression – medication and psychotherapy – are effective for some but not all clients. New approaches need to be developed to complement the ones already available.
E. Wood, T. Ricketts, G. Parry
semanticscholar +3 more sources
Phosphoprofile reorganization of the actin binding protein Drebrin during long term depression [PDF]
Frontiers in Molecular NeuroscienceDrebrin (DBN), an actin-binding protein critical for the structural integrity and function of dendritic spines, is highly phosphorylated at steady state in neurons.
Rafaela Pedro Silva +6 more
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Long-term potentiation and long-term depression: a clinical perspective [PDF]
Clinics, 2011 Long-term potentiation and long-term depression are enduring changes in synaptic strength, induced by specific patterns of synaptic activity, that have received much attention as cellular models of information storage in the central nervous system.
Timothy V.P. Bliss, Sam F. Cooke
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Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer’s disease? [PDF]
Neural Regeneration Research, 2023 Cognitive decline in Alzheimer’s disease correlates with the extent of tau pathology, in particular tau hyperphosphorylation that initially appears in the transentorhinal and related regions of the brain including the hippocampus.
Zhengtao Hu +8 more
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A methylation study of long term depression risk [PDF]
Mol Psychiatry, 2019 Recurrent and chronic major depressive disorder (MDD) accounts for a substantial part of the disease burden because this course is most prevalent and typically requires long-term treatment.
S. Clark +13 more
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NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 Long-term potentiation and long-term depression (LTP/LTD) can be elicited by activating N-methyl-d-aspartate (NMDA)-type glutamate receptors, typically by the coincident activity of pre- and postsynaptic neurons. The early phases of expression are mediated by a redistribution of AMPA-type glutamate receptors: More receptors are added to potentiate the ...
C. Lüscher, R. Malenka
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Nature Communications, 2019 How astrocytes influence neuronal plasticity remains unclear, as they are typically considered as modulators of core mechanisms driven by neuronal components.
Marta Navarrete +10 more
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Presynaptic Spike Timing-Dependent Long-Term Depression in the Mouse Hippocampus [PDF]
Cerebral Cortex, 2016 Spike timing-dependent plasticity (STDP) is a Hebbian learning rule important for synaptic refinement during development and for learning and memory in the adult.
Y. Andrade-Talavera +3 more
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The Intriguing Contribution of Hippocampal Long-Term Depression to Spatial Learning and Long-Term Memory [PDF]
Frontiers in Behavioral Neuroscience, 2022 Long-term potentiation (LTP) and long-term depression (LTD) comprise the principal cellular mechanisms that fulfill established criteria for the physiological correlates of learning and memory. Traditionally LTP, that increases synaptic weights, has been
Martin Stacho, Denise Manahan-Vaughan
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