Long-term potentiation and long-term depression: a clinical perspective [PDF]
Clinics, 2011 Long-term potentiation and long-term depression are enduring changes in synaptic strength, induced by specific patterns of synaptic activity, that have received much attention as cellular models of information storage in the central nervous system.
Timothy V.P. Bliss, Sam F. Cooke
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Astrocyte and neuron cooperation in long-term depression. [PDF]
Trends Neurosci, 2021 Activity-dependent long-term changes in synaptic transmission known as synaptic plasticity are fundamental processes in brain function and are recognized as the cellular basis of learning and memory. While the neuronal mechanisms underlying synaptic plasticity have been largely identified, the involvement of astrocytes in these processes has been less ...
Durkee C +3 more
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Alteration of the gut microbiome and correlated metabolism in a rat model of long-term depression [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 ObjectiveThis study aims to investigate the composition and function of the gut microbiome in long-term depression using an 8-week chronic unpredictable mild stress (CUMS) rat model.Materials and methodsAnimals were sacrificed after either 4 weeks or 8 ...
Yubo Li +12 more
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A methylation study of long-term depression risk. [PDF]
Mol Psychiatry, 2020 Recurrent and chronic major depressive disorder (MDD) accounts for a substantial part of the disease burden because this course is most prevalent and typically requires long-term treatment.
Clark SL +13 more
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NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95. [PDF]
Nat Commun, 2021 Long-term depression (LTD) of synaptic strength can take multiple forms and contribute to circuit remodeling, memory encoding or erasure. The generic term LTD encompasses various induction pathways, including activation of NMDA, mGlu or P2X receptors ...
Compans B +16 more
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Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer’s disease? [PDF]
Neural Regeneration Research, 2023 Cognitive decline in Alzheimer’s disease correlates with the extent of tau pathology, in particular tau hyperphosphorylation that initially appears in the transentorhinal and related regions of the brain including the hippocampus.
Zhengtao Hu +8 more
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The Intriguing Contribution of Hippocampal Long-Term Depression to Spatial Learning and Long-Term Memory [PDF]
Frontiers in Behavioral Neuroscience, 2022 Long-term potentiation (LTP) and long-term depression (LTD) comprise the principal cellular mechanisms that fulfill established criteria for the physiological correlates of learning and memory. Traditionally LTP, that increases synaptic weights, has been
Martin Stacho, Denise Manahan-Vaughan
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Nature Communications, 2019 How astrocytes influence neuronal plasticity remains unclear, as they are typically considered as modulators of core mechanisms driven by neuronal components.
Marta Navarrete +10 more
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Implementation of Neuro-Memristive Synapse for Long-and Short-Term Bio-Synaptic Plasticity
Sensors, 2021 In this paper, we propose a complex neuro-memristive synapse that exhibits the physiological acts of synaptic potentiation and depression of the human-brain.
Zubaer I. Mannan +2 more
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Peers, Gender, and Long-Term Depression [PDF]
SSRN Electronic Journal, 2020 We provide first evidence that peer depression in adolescence affects own depression in adulthood. We use data from Add Health and an identification strategy that relies on within-school and across-cohort idiosyncratic variation in the share of own-gender peers who are depressed. We find a significant peer effect for females but not for males.
Corrado Giulietti +2 more
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