Results 1 to 10 of about 4,459,968 (325)

Alteration of the gut microbiome and correlated metabolism in a rat model of long-term depression [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
ObjectiveThis study aims to investigate the composition and function of the gut microbiome in long-term depression using an 8-week chronic unpredictable mild stress (CUMS) rat model.Materials and methodsAnimals were sacrificed after either 4 weeks or 8 ...
Yubo Li, Junling Li, Ran Cheng, Haixia Liu, Yukun Zhao, Yanjun Liu, Yanjing Chen, Zhibo Sun, Zhiguang Zhai, Meng Wu, Yupeng Yan, Yuxiu Sun, Zhiguo Zhang   +12 more
doaj   +4 more sources

EMDR as a treatment for long term depression: a feasibility study [PDF]

Psychology and psychotherapy, 2017
Objective. Current treatments for long-term depression – medication and psy-chotherapy – are effective for some but not all clients. New approaches need to bedeveloped to complement the ones already available.
APA, APA, Arabia, Bae, Bagby, Barkham, Barlow, Beck, Bernet, Bisson, Butler, Chapman, Craig, Creamer, Cuijpers, Cusin, Department of Health, Dozois, Gilbody, Grey, Hamilton, Heim, Hofmann, Ironson, Jacobson, Kaplan, Kellett, Klein, Kroenke, Kroenke, Lee, Lenze, Miller, NCCMH, Novo, Olfson, Parry, Riso, Roth, Schramm, Shapero, Shapiro, Shapiro, Shapiro, Sharp, Sheehan, Smarr, Solomon, Steer, Torpey, Turpin, van der Kolk, WHO, Wiersma, Wood   +54 more
core   +2 more sources

A methylation study of long-term depression risk. [PDF]

Mol Psychiatry, 2020
Recurrent and chronic major depressive disorder (MDD) accounts for a substantial part of the disease burden because this course is most prevalent and typically requires long-term treatment.
Clark SL, Hattab MW, Chan RF, Shabalin AA, Han LKM, Zhao M, Smit JH, Jansen R, Milaneschi Y, Xie LY, van Grootheest G, Penninx BWJH, Aberg KA, van den Oord EJCG.   +13 more
europepmc   +2 more sources

Phosphoprofile reorganization of the actin binding protein Drebrin during long term depression [PDF]

Frontiers in Molecular Neuroscience
Drebrin (DBN), an actin-binding protein critical for the structural integrity and function of dendritic spines, is highly phosphorylated at steady state in neurons.
Rafaela Pedro Silva, Rafaela Pedro Silva, Till G. A. Mack, Marieluise Kirchner, Philipp Mertins, Britta J. Eickholt, Patricia Kreis   +6 more
doaj   +2 more sources

Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer’s disease? [PDF]

Neural Regeneration Research, 2023
Cognitive decline in Alzheimer’s disease correlates with the extent of tau pathology, in particular tau hyperphosphorylation that initially appears in the transentorhinal and related regions of the brain including the hippocampus.
Zhengtao Hu, Tomas Ondrejcak, Pengpeng Yu, Yangyang Zhang, Yin Yang, Igor Klyubin, Sean P Kennelly, Michael J Rowan, Neng-Wei Hu   +8 more
doaj   +2 more sources

Presynaptic Spike Timing-Dependent Long-Term Depression in the Mouse Hippocampus. [PDF]

Cerebral Cortex, 2016
Spike timing-dependent plasticity (STDP) is a Hebbian learning rule important for synaptic refinement during development and for learning and memory in the adult.
Andrade-Talavera, Yuniesky, Duque-Feria, Paloma, Paulsen, Ole, Rodríguez-Moreno, Antonio   +3 more
core   +3 more sources

Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory

Nature Communications, 2019
How astrocytes influence neuronal plasticity remains unclear, as they are typically considered as modulators of core mechanisms driven by neuronal components.
Marta Navarrete, María I. Cuartero, Rocío Palenzuela, Jonathan E. Draffin, Ainoa Konomi, Irene Serra, Sandra Colié, Sergio Castaño-Castaño, Mazahir T. Hasan, Ángel R. Nebreda, José A. Esteban   +10 more
doaj   +2 more sources

The Intriguing Contribution of Hippocampal Long-Term Depression to Spatial Learning and Long-Term Memory [PDF]

Frontiers in Behavioral Neuroscience, 2022
Long-term potentiation (LTP) and long-term depression (LTD) comprise the principal cellular mechanisms that fulfill established criteria for the physiological correlates of learning and memory. Traditionally LTP, that increases synaptic weights, has been
Martin Stacho, Denise Manahan-Vaughan
doaj   +2 more sources

Astrocyte and neuron cooperation in long-term depression. [PDF]

Trends Neurosci, 2021
Durkee C, Kofuji P, Navarrete M, Araque A.   +3 more
europepmc   +2 more sources

Olfactory threat extinction in the piriform cortex: An age-dependent employment of NMDA receptor-dependent long-term depression. [PDF]

Proc Natl Acad Sci U S A, 2023
Sepahvand T, Nazari N, Qin T, Rajani V, Yuan Q.   +4 more
europepmc   +2 more sources