Alteration of the gut microbiome and correlated metabolism in a rat model of long-term depression [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 ObjectiveThis study aims to investigate the composition and function of the gut microbiome in long-term depression using an 8-week chronic unpredictable mild stress (CUMS) rat model.Materials and methodsAnimals were sacrificed after either 4 weeks or 8 ...
Yubo Li +12 more
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Phosphoprofile reorganization of the actin binding protein Drebrin during long term depression [PDF]
Frontiers in Molecular NeuroscienceDrebrin (DBN), an actin-binding protein critical for the structural integrity and function of dendritic spines, is highly phosphorylated at steady state in neurons.
Rafaela Pedro Silva +6 more
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Long-term potentiation and long-term depression: a clinical perspective [PDF]
Clinics, 2011 Long-term potentiation and long-term depression are enduring changes in synaptic strength, induced by specific patterns of synaptic activity, that have received much attention as cellular models of information storage in the central nervous system.
Timothy V.P. Bliss, Sam F. Cooke
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Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer’s disease? [PDF]
Neural Regeneration Research, 2023 Cognitive decline in Alzheimer’s disease correlates with the extent of tau pathology, in particular tau hyperphosphorylation that initially appears in the transentorhinal and related regions of the brain including the hippocampus.
Zhengtao Hu +8 more
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The Intriguing Contribution of Hippocampal Long-Term Depression to Spatial Learning and Long-Term Memory [PDF]
Frontiers in Behavioral Neuroscience, 2022 Long-term potentiation (LTP) and long-term depression (LTD) comprise the principal cellular mechanisms that fulfill established criteria for the physiological correlates of learning and memory. Traditionally LTP, that increases synaptic weights, has been
Martin Stacho, Denise Manahan-Vaughan
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European Journal of Cell Biology, 2023 Dendritic spines form the postsynaptic compartment of most excitatory synapses in the vertebrate brain. Morphological changes of dendritic spines contribute to major forms of synaptic plasticity such as long-term potentiation (LTP) or depression (LTD ...
Anika Heinze, Marco B. Rust
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Implementation of Neuro-Memristive Synapse for Long-and Short-Term Bio-Synaptic Plasticity
Sensors, 2021 In this paper, we propose a complex neuro-memristive synapse that exhibits the physiological acts of synaptic potentiation and depression of the human-brain.
Zubaer I. Mannan +2 more
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LIM-Kinases in Synaptic Plasticity, Memory, and Brain Diseases
Cells, 2021 Learning and memory require structural and functional modifications of synaptic connections, and synaptic deficits are believed to underlie many brain disorders.
Youssif Ben Zablah +3 more
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Molecular Brain, 2022 Cyclin-dependent kinase 5 (Cdk5) /p35 is involved in many developmental processes of the central nervous system. Cdk5/p35 is also implicated in synaptic plasticity, learning and memory.
Miyuki Takahashi +9 more
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Purkinje cells translate subjective salience into readiness to act and choice performance
Cell Reports, 2021 Summary: The brain selectively allocates attention from a continuous stream of sensory input. This process is typically attributed to computations in distinct regions of the forebrain and midbrain.
Lorenzo Bina +4 more
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