Results 11 to 20 of about 4,590,611 (322)

Astrocyte and neuron cooperation in long-term depression [PDF]

Trends Neurosci, 2021
Caitlin A. Durkee, P. Kofuji, M. Navarrete, A. Araque   +3 more
semanticscholar   +2 more sources

Loss of the actin regulator cyclase-associated protein 1 (CAP1) modestly affects dendritic spine remodeling during synaptic plasticity

European Journal of Cell Biology, 2023
Dendritic spines form the postsynaptic compartment of most excitatory synapses in the vertebrate brain. Morphological changes of dendritic spines contribute to major forms of synaptic plasticity such as long-term potentiation (LTP) or depression (LTD ...
Anika Heinze, Marco B. Rust
doaj   +1 more source

NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95

Nature Communications, 2021
Long-term depression (LTD) of synaptic strength can take multiple forms and contribute to circuit remodeling, memory encoding or erasure. The generic term LTD encompasses various induction pathways, including activation of NMDA, mGlu or P2X receptors ...
Benjamin Compans, Côme Camus, Emmanouela Kallergi, S. Sposini, M. Martineau, C. Butler, Adel Kechkar, R. Klaassen, Natacha Retailleau, T. Sejnowski, A. Smit, J. Sibarita, T. Bartol, D. Perrais, V. Nikoletopoulou, D. Choquet, E. Hosy   +16 more
semanticscholar   +1 more source

Implementation of Neuro-Memristive Synapse for Long-and Short-Term Bio-Synaptic Plasticity

Sensors, 2021
In this paper, we propose a complex neuro-memristive synapse that exhibits the physiological acts of synaptic potentiation and depression of the human-brain.
Zubaer I. Mannan, Hyongsuk Kim, Leon Chua   +2 more
doaj   +1 more source

LIM-Kinases in Synaptic Plasticity, Memory, and Brain Diseases

Cells, 2021
Learning and memory require structural and functional modifications of synaptic connections, and synaptic deficits are believed to underlie many brain disorders.
Youssif Ben Zablah, Haiwang Zhang, Radu Gugustea, Zhengping Jia   +3 more
doaj   +1 more source

Involvement of Cdk5 activating subunit p35 in synaptic plasticity in excitatory and inhibitory neurons

Molecular Brain, 2022
Cyclin-dependent kinase 5 (Cdk5) /p35 is involved in many developmental processes of the central nervous system. Cdk5/p35 is also implicated in synaptic plasticity, learning and memory.
Miyuki Takahashi, Takeru Nakabayashi, Naoki Mita, Xiaohua Jin, Yuta Aikawa, Kodai Sasamoto, Goichi Miyoshi, Mariko Miyata, Takafumi Inoue, Toshio Ohshima   +9 more
doaj   +1 more source

Purkinje cells translate subjective salience into readiness to act and choice performance

Cell Reports, 2021
Summary: The brain selectively allocates attention from a continuous stream of sensory input. This process is typically attributed to computations in distinct regions of the forebrain and midbrain.
Lorenzo Bina, Vincenzo Romano, Tycho M. Hoogland, Laurens W.J. Bosman, Chris I. De Zeeuw   +4 more
doaj   +1 more source

Astrocyte Signaling Gates Long-Term Depression at Corticostriatal Synapses of the Direct Pathway

Journal of Neuroscience, 2020
Despite extensive research into understanding synaptic mechanisms of striatal plasticity, the functional role played by astrocytes in this region remains to be fully elucidated.
A. Cavaccini, Caitlin A. Durkee, P. Kofuji, R. Tonini, A. Araque   +4 more
semanticscholar   +1 more source

Mapping dynamic interactions among cognitive biases in depression [PDF]

, 2020
Depression is theorized to be caused in part by biased cognitive processing of emotional information. Yet, prior research has adopted a reductionist approach that does not characterize how biases in cognitive processes such as attention and memory work ...
Bernstein, Amit, Everaert, Jonas, Joormann, Jutta, Koster, Ernst   +3 more
core   +1 more source

Rho Signaling in Synaptic Plasticity, Memory, and Brain Disorders

Frontiers in Cell and Developmental Biology, 2021
Memory impairments are associated with many brain disorders such as autism, Alzheimer’s disease, and depression. Forming memories involves modifications of synaptic transmission and spine morphology.
Haorui Zhang, Haorui Zhang, Youssif Ben Zablah, Youssif Ben Zablah, Haiwang Zhang, Haiwang Zhang, Zhengping Jia, Zhengping Jia   +7 more
doaj   +1 more source