Results 81 to 90 of about 4,590,611 (322)

mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo

Nature Communications, 2014
NMDA-type glutamate receptors (NMDARs) are currently regarded as paramount in the potent and selective disruption of synaptic plasticity by Alzheimer’s disease amyloid β-protein (Aβ). Non-NMDAR mechanisms remain relatively unexplored.
Neng-Wei Hu, Andrew J. Nicoll, Dainan Zhang, Alexandra J Mably, Tiernan T O'Malley, Silvia A. Purro, C. Terry, J. Collinge, D. Walsh, M. Rowan   +9 more
semanticscholar   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

Long-term outcomes of trials in the National Institute for Health and Care Excellence depression guideline

BJPsych Open, 2019
The forthcoming National Institute for Health and Care Excellence depression guideline reviews short-term outcomes for long-term depression. We present effect sizes for long-term outcomes in trials that report these data.
Susan McPherson, Michael P. Hengartner
doaj   +1 more source

Long-Term Depression of mGluR1 Signaling [PDF]

Neuron, 2007
Glutamate produces both fast excitation through activation of ionotropic receptors and slower actions through metabotropic receptors (mGluRs). To date, ionotropic but not metabotropic neurotransmission has been shown to undergo long-term synaptic potentiation and depression.
Jin, Yunju, Kim, Sang Jeong, Kim, Jun, Worley, Paul F., Linden, David J.   +4 more
openaire   +2 more sources

Use of Symptomatic Drug Treatment for Fatigue in Multiple Sclerosis and Patterns of Work Loss

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe the use of central stimulants and amantadine for fatigue in MS and evaluate a potential association with reduced work loss in people with MS. Methods We conducted a nationwide, matched, register‐based cohort study in Sweden (2006 to 2023) using national registers with prospective data collection.
Simon Englund, Johan Reutfors, Thomas Frisell, Fredrik Piehl   +3 more
wiley   +1 more source

Metabolic Profile and Long-Term Risk of Depression, Anxiety, and Stress-Related Disorders

JAMA Network Open
Key Points Question Are the biomarkers of carbohydrate, lipid, and apolipoprotein metabolism associated with the risk of depression, anxiety, and stress-related disorders?
Charilaos Chourpiliadis, Yu Zeng, Aniko Lovik, Dang Wei, U. Valdimarsdóttir, Huan Song, Niklas Hammar, Fang Fang   +7 more
semanticscholar   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

The self-management of longer-term depression: learning from the patient, a qualitative study [PDF]

, 2015
Background Depression is a common mental health condition now viewed as chronic or long-term. More than 50 % of people will have at least one further episode of depression after their first, and therefore it requires long-term management.
A Coulter, A Faulkner, A Giorgi, A Holzinger, AF Jorm, AJ Morgan, Alexis Foster, Anna Thake, B Schrank, C Chew-Graham, C Johnson, C McDonald, D Richards, DJ Kupfer, DV Sheehan, E Fossey, E Marley, Eleni Chambers, G Lewis, G Shepherd, Glenys Parry, J Aked, J Barlow, J Gellatly, J Houle, J Kalathil, J Wallcraft, JA Smith, JA Smith, KE Biesheuvel-Leliefeld, L Davidson, L Finlay, LJ Barney, M Larkin, M Lucock, N Mays, N Mays, National Collaborating Centre for Mental Health: Depression, P Bower, PC Boer den, R Pratt, R Shaw, RA Grieken van, Rebecca Hutten, S Allam, S Bonney, S Gillard, S Martindale, S Newman, S Pilling, Sarah Cook, Sue Shaw, T Stickley, T Stickley, TM Harwood, Tom Ricketts, V Braun   +56 more
core   +1 more source

Nitric Oxide Facilitates Long-Term Potentiation, But Not Long-Term Depression [PDF]

The Journal of Neuroscience, 1997
Reports that nitric oxide synthase (NOS) inhibition prevents the induction of long-term potentiation (LTP) have been controversial. Recent evidence suggests that NO may help to regulate the threshold for LTP induction. We have tested this hypothesis by examining the effects of stimulus frequency and train duration on synaptic plasticity in the presence
P L, Malen, P F, Chapman
openaire   +2 more sources

Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim, Han Gil Seo, Roh‐Eul Yoo, Byung‐Mo Oh   +3 more
wiley   +1 more source