Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus [PDF]
, 1997 Autophosphorylation of calcium/calmodulin-dependent protein kinase II (CaMKII) at threonine-286 produces Ca2+-independent kinase activity and has been proposed to be involved in induction of long-term potentiation by tetanic stimulation in the ...
Harris, Kristen M. +4 more
core +2 more sources
Long term potentiation depends on release of D-serine from astrocytes
Nature, 2009 Long-term potentiation (LTP) of synaptic transmission provides an experimental model for studying mechanisms of memory. The classical form of LTP relies on N-methyl-d-aspartate receptors (NMDARs), and it has been shown that astroglia can regulate their ...
C. Henneberger +3 more
semanticscholar +1 more source
Long Term Potentiation (LTP) and Long Term Depression (LTD) Cause Differential Spatial Redistribution of the Synaptic Vesicle Protein Synaptophysin in the Middle Molecular Layer of the Dentate Gyrus in Rat Hippocampus [PDF]
, 2016 The presynaptic modifications that accompany long-term changes in synaptic plasticity are still not fully understood. Synaptophysin is a major synaptic vesicle protein involved in neurotransmitter release. We have used quantitative electron microscopy to
Chaudhury, Sraboni +5 more
core +1 more source
Frontiers in Behavioral Neuroscience, 2009 Synaptic plasticity in the amydgala is essential for emotional learning. Fear conditioning, for example, depends on changes in excitatory transmission that occur following NMDA receptor activation and AMPA receptor modification in this region. The role
Brian J Wiltgen +17 more
doaj +1 more source
Long Term Potentiation as a Mechanism for Learning and Memory [PDF]
Cell Journal, 2009 Since the 1970s when long term potentiation (LTP) was introduced to the scientific world;several studies have been devoted to determining whether this phenomenon is naturally abasic mechanism of learning and memory in mammalian brains. However, plenty of
Gholamali Hamidi +2 more
doaj
Temporal sensitivity of protein kinase a activation in late-phase long term potentiation. [PDF]
PLoS Computational Biology, 2010 Protein kinases play critical roles in learning and memory and in long term potentiation (LTP), a form of synaptic plasticity. The induction of late-phase LTP (L-LTP) in the CA1 region of the hippocampus requires several kinases, including CaMKII and PKA,
MyungSook Kim +3 more
doaj +1 more source
Chronic administration of atypical antipsychotics improves behavioral and synaptic defects of STOP null mice. [PDF]
, 2009 International audienceINTRODUCTION: Recent studies have suggested that schizophrenia is associated with alterations in the synaptic connectivity involving cytoskeletal proteins.
Annie Andrieux +9 more
core +5 more sources
Effects of intra-dentate gyrus microinjection of myokine irisin on long-term potentiation in male rats [PDF]
Arquivos de Neuro-Psiquiatria, 2020 Induction of long-term potentiation (LTP) increases the storage capacity of synapses in the hippocampal dentate gyrus (DG). Irisin is a myokine generated from FNDC5 (a gene precursor) during exercise.
Saeed Mohammadi +4 more
doaj +1 more source
Erythropoietin enhances hippocampal long-term potentiation and memory
BMC Biology, 2008 Background Erythropoietin (EPO) improves cognition of human subjects in the clinical setting by as yet unknown mechanisms. We developed a mouse model of robust cognitive improvement by EPO to obtain the first clues of how EPO influences cognition, and ...
El-Kordi Ahmed +19 more
doaj +1 more source
Long-term potentiation in frontal cortex: Role of NMDA-modulated polysynaptic excitatory pathways [PDF]
, 1989 The present study examined the role of N-methyl-D-aspartic acid (NMDA) receptors in synaptic plasticity in regular-spiking cells of rat frontal cortex. Intracortical stimulation, at levels subthreshold for elicitation of action potentials, evoked a late ...
Hablitz, John H., Sutor, Bernd
core +1 more source