Results 51 to 60 of about 3,075,584 (328)

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice

eLife, 2016
PKMζ is a persistently active PKC isoform proposed to maintain late-LTP and long-term memory. But late-LTP and memory are maintained without PKMζ in PKMζ-null mice. Two hypotheses can account for these findings.
P. Tsokas, Changchi Hsieh, Yudong Yao, Edith Lesburguères, Emma J C Wallace, A. Tcherepanov, D. Jothianandan, B. Hartley, Ling Pan, B. Rivard, Robert V Farese, M. Sajan, P. Bergold, A. Hernández, J. Cottrell, H. Shouval, A. Fenton, T. Sacktor   +17 more
semanticscholar   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects

Advanced Functional Materials, EarlyView.
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu, Jueun Kim, Dae‐Hyun Kim, Sewoom Baek, Suji Park, Seyong Chung, Hak‐Joon Sung   +6 more
wiley   +1 more source

Green's functions for reflectionless potentials and addition of boundstates to powerlaw potentials to find Supersymmetric partners [PDF]

arXiv, 2021
Green's functions for reflectionless potentials are constructed and analyzed. Green's functions for power law potentials, their Super Symmetric partners and sum rules for eigenvalues are examined. The SUSY partner potentials to power law potentials which have an additional bound state at $E=0$ are constructed.
arxiv  

Ultra‐Fast Non‐Volatile Resistive Switching Devices with Over 512 Distinct and Stable Levels for Memory and Neuromorphic Computing

Advanced Functional Materials, EarlyView.
A materials and device design concept that comprises a self‐assembled ultra‐thin epitaxial ion‐transporting layer, an amorphous oxide overcoat oxygen‐blocking layer, and a partial filament formed during an electroforming step is proposed for low‐current multilevel resistive switching devices.
Ming Xiao, Markus Hellenbrand, Nives Strkalj, Babak Bakhit, Zhuotong Sun, Nikolaos Barmpatsalos, Dovydas Joksas, Hongyi Dou, Zedong Hu, Ping Lu, Samip Karki, Sundar Kunwar, Jonathan D. Major, Aiping Chen, Haiyan Wang, Quanxi Jia, Adnan Mehonic, Judith L. MacManus‐Driscoll   +17 more
wiley   +1 more source

Vitamin D Alterations in Food Regimens and Synaptic Transmission in Neuronal Circuit

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2012
Background and Objectives: In nervous system, through specific channels and some ionotropic receptors, calcium ion involves in synaptic transmission vitamin D takes an important role in cellular regulation as well.
M Taghizadeh, A Jazayeri, AR Talaei Zavareh, S Davari, M Salami, M Keshavarz, T Mazuchi   +6 more
doaj   +2 more sources

Concentrations for nonlinear Schrodinger equation with magnetic potentials and constant electric potentials [PDF]

arXiv, 2022
This paper studies the concentration phenomena to nonlinear Schrodinger equations with magnetic potentials and constant electric potentials. We find that the magnetic field plays an important role in the location of concentrations if the electric potential is constant.
arxiv  

Transient Current Responses of Organic Electrochemical Transistors: Evaluating Ion Diffusion, Chemical Capacitance, and Series Elements

Advanced Functional Materials, EarlyView.
This work establishes a general theory of the current transient of ionic‐electronic transistors under a step of gate voltage. The dominant effect is a transient charging of the channel by diffusion of ions. The additional influence of electrolyte capacitance and resistance splits the fundamental time constant of diffusion into two different components.
Juan Bisquert, Nir Tessler
wiley   +1 more source

Stress and Corticosteroids Modulate Muscarinic Long Term Potentiation (mLTP) in the Hippocampus

Frontiers in Cellular Neuroscience, 2017
Stress influences synaptic plasticity, learning and memory in a steroid hormone receptor dependent manner. Based on these findings it has been proposed that stress could be a major risk factor for the development of cognitive decline and dementia ...
Efrat Shavit Stein, Ze’Ev Itsekson Hayosh, Andreas Vlachos, Nicola Maggio, Nicola Maggio, Nicola Maggio, Nicola Maggio   +6 more
doaj   +1 more source