Results 61 to 70 of about 3,354,348 (302)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

EMPIRICAL STRENGTH CRITERION OF COMPOSITE MATERIALS

open access: yesВестник Донского государственного технического университета, 2018
Empirical long-term strength criterion in terms of limit stress for constructive polymer materials considering ageing factor is found. The criterion corresponds to the type of Goldenblat - Kopnov.
O.G. OSYAEV
doaj  

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Assessment of Individual Resource of High-Pressure Rotors of Nuclear Power Plants Steam Turbines

open access: yesJournal of Mechanical Engineering, 2022
Integration of the Ukrainian energy system into the European one is a component of Ukraine's strategic goal – joining the EU. Our country has sufficiently strong and developed gas and oil transport networks, as well as electricity networks, all connected
Olha Yu. Chernousenko
doaj   +1 more source

Nonlinear vibrations and long-term strength of turbine blades [PDF]

open access: yes, 2010
The method of a durability estimation of rotating turbomachinery blades at forced flexural-flexural-torsional vibrations is offered. The method is based on the methods of Continuous Damage Mechanics and the accurate strain analysis of the pre-twisted ...
Breslavsky, D. V.   +2 more
core  

Reduced energy availability: implications for bone health in physically active populations [PDF]

open access: yes, 2017
Purpose: The present review critically evaluates existing literature on the effects of short- and long-term low energy availability (EA) on bone metabolism and health in physically active individuals.
Dolan, E   +3 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Steam curing effect on the properties of fly ash high performance recycled aggregates concrete [PDF]

open access: yes, 2016
The aim of this study is to encourage the use of Recycled Concrete Aggregate (RCA) in High Performance Concrete (HPC) with fly ash. Three types of coarse RCA sourced from medium to high strength concretes were employed in 100% replacement.
Etxeberria Larrañaga, Miren   +1 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

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