Results 1 to 10 of about 71,947 (145)
mGluR5 Facilitates Long-Term Synaptic Depression in a Stress-Induced Depressive Mouse Model. [PDF]
Can J Psychiatry, 2020 Background Glutamatergic system has been known to play a role in the pathogenesis of major depression disorder by inducing N-methyl-d-aspartate receptor-dependent long-term depression (LTD) or metabotropic glutamate receptors (mGluR)-dependent LTD. Here, we characterized the LTD in a chronic social defeat stress (CSDS)-induced depressive mouse model ...
Jiang X, Lin W, Cheng Y, Wang D.
europepmc +4 more sources
A Late Phase of Long-Term Synaptic Depression in Cerebellar Purkinje Cells Requires Activation of MEF2 [PDF]
Cell Reports, 2019 Summary: The MEF2 family of transcription factors restricts excitatory synapse number in an activity-dependent fashion during development, yet MEF2 has not been implicated in long-term synaptic depression (LTD), which is thought to initiate synapse ...
Milena M. Andzelm +3 more
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Progressive long-term synaptic depression at cortical inputs into the amygdala. [PDF]
NeuroscienceThe convergence of conditioned and unconditioned stimuli (CS and US) into the lateral amygdala (LA) serves as a substrate for an adequate fear response in vivo. This well-known Pavlovian paradigm modulates the synaptic plasticity of neurons, as can be proved by the long-term potentiation (LTP) phenomenon in vitro.
Psyrakis D +5 more
europepmc +4 more sources
Local Iontophoretic Application for Pharmacological Induction of Long-Term Synaptic Depression [PDF]
Bio-ProtocolLong-term depression (LTD), a key form of synaptic plasticity, is typically induced through regulated Ca2+ entry via NMDA receptors and achieved by prolonged (up to hundreds of seconds) low-frequency presynaptic stimulation or bath application of NMDA ...
Borys Olifirov +6 more
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Implementation of Neuro-Memristive Synapse for Long-and Short-Term Bio-Synaptic Plasticity
Sensors, 2021 In this paper, we propose a complex neuro-memristive synapse that exhibits the physiological acts of synaptic potentiation and depression of the human-brain.
Zubaer I. Mannan +2 more
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Low-Consumption Synaptic Devices Based on Gate-All-Around InAs Nanowire Field-Effect Transistors
Nanoscale Research Letters, 2022 In this work, an artificial electronic synaptic device based on gate-all-around InAs nanowire field-effect transistor is proposed and analyzed. The deposited oxide layer (In2O3) on the InAs nanowire surface serves as a charge trapping layer for ...
Chaofei Zha +4 more
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IGF-1 facilitates extinction of conditioned fear
eLife, 2021 Insulin-like growth factor-1 (IGF-1) plays a key role in synaptic plasticity, spatial learning, and anxiety-like behavioral processes. While IGF-1 regulates neuronal firing and synaptic transmission in many areas of the central nervous system, its ...
Laura E Maglio +6 more
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Stress and long-term synaptic depression [PDF]
Molecular Psychiatry, 1998 Acute inescapable stress reverses the direction of synaptic plasticity in the intact hippocampus via a corticosterone-mediated activation of glucocorticoid receptors and protein/RNA synthesis.
M J Rowan, R Anwyl, L Xu
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Long-Term Depression of Kainate Receptor-Mediated Synaptic Transmission [PDF]
Neuron, 2006 Kainate receptors (KARs) have been shown to be involved in hippocampal mossy fiber long-term potentiation (LTP); however, it is not known if KARs are involved in the induction or expression of long-term depression (LTD), the other major form of long-term synaptic plasticity.
Park, Y, Jo, J, Isaac, JTR, Cho, K
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Molecular Brain, 2022 Cyclin-dependent kinase 5 (Cdk5) /p35 is involved in many developmental processes of the central nervous system. Cdk5/p35 is also implicated in synaptic plasticity, learning and memory.
Miyuki Takahashi +9 more
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