Results 11 to 20 of about 72,066 (264)

Aberrant Synaptic PTEN in Symptomatic Alzheimer’s Patients May Link Synaptic Depression to Network Failure

Frontiers in Synaptic Neuroscience, 2021
In Alzheimer’s disease (AD), Amyloid β (Aβ) impairs synaptic function by inhibiting long-term potentiation (LTP), and by facilitating long-term depression (LTD).
Marta Díaz González, Assaf Buberman, Miguel Morales, Isidro Ferrer, Shira Knafo, Shira Knafo, Shira Knafo   +6 more
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Tunable Synaptic Plasticity in Crystallized Conjugated Polymer Nanowire Artificial Synapses

Advanced Intelligent Systems, 2020
In biological synapses, short‐term plasticity is important for computation and signal transmission, whereas long‐term plasticity is essential for memory formation.
Hong Han, Zhipeng Xu, Kexin Guo, Yao Ni, Mingxue Ma, Haiyang Yu, Huanhuan Wei, Jiangdong Gong, Shuo Zhang, Wentao Xu   +9 more
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Rho Signaling in Synaptic Plasticity, Memory, and Brain Disorders

Frontiers in Cell and Developmental Biology, 2021
Memory impairments are associated with many brain disorders such as autism, Alzheimer’s disease, and depression. Forming memories involves modifications of synaptic transmission and spine morphology.
Haorui Zhang, Haorui Zhang, Youssif Ben Zablah, Youssif Ben Zablah, Haiwang Zhang, Haiwang Zhang, Zhengping Jia, Zhengping Jia   +7 more
doaj   +1 more source

Long-term potentiation and long-term depression: a clinical perspective

Clinics, 2011
Long-term potentiation and long-term depression are enduring changes in synaptic strength, induced by specific patterns of synaptic activity, that have received much attention as cellular models of information storage in the central nervous system.
Timothy V.P. Bliss, Sam F. Cooke
doaj   +1 more source

Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression

Cell Reports, 2019
Summary: Myosin VI is an actin-based cytoskeletal motor implicated in various steps of membrane trafficking. Here, we investigated whether this myosin is crucial for synaptic function and plasticity in neurons.
Wolfgang Wagner, Kristina Lippmann, Frank F. Heisler, Kira V. Gromova, Franco L. Lombino, Mona K. Roesler, Yvonne Pechmann, Sönke Hornig, Michaela Schweizer, Simona Polo, Jürgen R. Schwarz, Jens Eilers, Matthias Kneussel   +12 more
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Long-term environmental enrichment overcomes depression, learning, and memory impairment in elderly CD-1 mice with maternal sleep deprivation exposure

Frontiers in Aging Neuroscience, 2023
Early-life stress disrupts central nervous system development and increases the risk of neuropsychiatric disorder in offspring based on rodent studies.
Yue-Ming Zhang, Ru-Meng Wei, Xue-Yan Li, Yi-Zhou Feng, Kai-Xuan Zhang, Yi-Jun Ge, Xiao-Yi Kong, Xue-Chun Liu, Gui-Hai Chen   +8 more
doaj   +1 more source

Purkinje cell intrinsic excitability increases after synaptic long term depression [PDF]

Journal of Neurophysiology, 2016
Coding in cerebellar Purkinje cells not only depends on synaptic plasticity but also on their intrinsic membrane excitability. We performed whole cell patch-clamp recordings of Purkinje cells in sagittal cerebellar slices in mice. We found that inducing long-term depression (LTD) in the parallel fiber to Purkinje cell synapses results in an increase ...
Zhen Yang, Fidel Santamaria
openaire   +2 more sources

Bidirectional Synaptic Plasticity Is Driven by Sex Neurosteroids Targeting Estrogen and Androgen Receptors in Hippocampal CA1 Pyramidal Neurons

Frontiers in Cellular Neuroscience, 2019
Neuroactive estrogenic and androgenic steroids influence synaptic transmission, finely modulating synaptic plasticity in several brain regions including the hippocampus.
Alessandro Tozzi, Valentina Durante, Paolo Manca, Michela Di Mauro, Juan Blasi, Silvarosa Grassi, Paolo Calabresi, Suguru Kawato, Suguru Kawato, Vito Enrico Pettorossi   +9 more
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Levetiracetam Reduced the Basal Excitability of the Dentate Gyrus without Restoring Impaired Synaptic Plasticity in Rats with Temporal Lobe Epilepsy

Brain Sciences, 2020
Temporal lobe epilepsy (TLE), the most common type of focal epilepsy, affects learning and memory; these effects are thought to emerge from changes in synaptic plasticity.
Guillermo González-H, Itzel Jatziri Contreras-García, Karla Sánchez-Huerta, Claudio M. T. Queiroz, Luis Ricardo Gallardo Gudiño, Julieta G. Mendoza-Torreblanca, Sergio R. Zamudio   +6 more
doaj   +1 more source

Decreased NR2B Subunit Synaptic Levels Cause Impaired Long-Term Potentiation But Not Long-Term Depression [PDF]

The Journal of Neuroscience, 2009
The discovery of the molecular mechanisms regulating the abundance of synaptic NMDA receptors is essential for understanding how synaptic plasticity, as well as excitotoxic events, are regulated. However, a complete understanding of the precise molecular mechanisms regulating the composition of the NMDA receptor complex at hippocampal synapse is still ...
Gardoni F, Mauceri D, Malinverno M, Polli F, COSTA, CINZIA, Tozzi, Alessandro, SILIQUINI, SABRINA, Picconi B, Cattabeni F, CALABRESI, PAOLO, Di Luca M.   +10 more
openaire   +3 more sources