Results 21 to 30 of about 72,066 (264)

Synaptic neurotransmission depression in ventral tegmental dopamine neurons and cannabinoid-associated addictive learning.

PLoS ONE, 2010
Drug addiction is an association of compulsive drug use with long-term associative learning/memory. Multiple forms of learning/memory are primarily subserved by activity- or experience-dependent synaptic long-term potentiation (LTP) and long-term ...
Zhiqiang Liu, Jing Han, Lintao Jia, Jean-Christian Maillet, Guang Bai, Lin Xu, Zhengping Jia, Qiaohua Zheng, Wandong Zhang, Robert Monette, Zul Merali, Zhou Zhu, Wei Wang, Wei Ren, Xia Zhang   +14 more
doaj   +1 more source

On the mechanism of synaptic depression induced by CaMKIIN, an endogenous inhibitor of CaMKII. [PDF]

PLoS ONE, 2012
Activity-dependent synaptic plasticity underlies, at least in part, learning and memory processes. NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) is a major synaptic plasticity model.
Camilo Gouet, Belen Aburto, Cecilia Vergara, Magdalena Sanhueza   +3 more
doaj   +1 more source

Numerical Simulation: Fluctuation in Background Synaptic Activity Regulates Synaptic Plasticity

Frontiers in Systems Neuroscience, 2021
Synaptic plasticity is vital for learning and memory in the brain. It consists of long-term potentiation (LTP) and long-term depression (LTD). Spike frequency is one of the major components of synaptic plasticity in the brain, a noisy environment ...
Yuto Takeda, Katsuhiko Hata, Katsuhiko Hata, Katsuhiko Hata, Katsuhiko Hata, Tokio Yamazaki, Masaki Kaneko, Masaki Kaneko, Osamu Yokoi, Chengta Tsai, Chengta Tsai, Kazuo Umemura, Tetsuro Nikuni   +12 more
doaj   +1 more source

Intermittent Hypoxia Disrupts Synaptic Long Term Depression

The FASEB Journal, 2019
Long term potentiation (LTP), activity‐dependent synaptic strengthening, and long term depression (LTD), activity dependent synaptic attenuation, are two forms of synaptic plasticity whose underlying mechanisms permit flexibility in synaptic communication and serve as substrates for learning and memory.
Alejandra Arias, Chinwendu Nwakudu, Maggie A Khuu, Alfredo J Garcia   +3 more
openaire   +1 more source

Short-term depression and long-term plasticity together tune sensitive range of synaptic plasticity.

PLoS Computational Biology, 2020
Synaptic efficacy is subjected to activity-dependent changes on short- and long time scales. While short-term changes decay over minutes, long-term modifications last from hours up to a lifetime and are thought to constitute the basis of learning and ...
Nicolas Deperrois, Michael Graupner
doaj   +1 more source

Amphetamine Blocks Long-Term Synaptic Depression in the Ventral Tegmental Area [PDF]

The Journal of Neuroscience, 2000
The mesolimbic dopamine system is essential for reward-seeking behavior, and drugs of abuse are thought to usurp the normal functioning of this pathway. A growing body of evidence suggests that glutamatergic synapses on dopamine neurons in the ventral tegmental area (VTA) are modified during exposure to addictive drugs, producing sensitization, a ...
S, Jones, J L, Kornblum, J A, Kauer
openaire   +2 more sources

Convergent evidence for abnormal striatal synaptic plasticity in dystonia

Neurobiology of Disease, 2010
Dystonia is a functionally disabling movement disorder characterized by abnormal movements and postures. Although substantial recent progress has been made in identifying genetic factors, the pathophysiology of the disease remains a mystery.
David A. Peterson, Terrence J. Sejnowski, Howard Poizner   +2 more
doaj   +1 more source

Long lasting protein synthesis- and activity-dependent spine shrinkage and elimination after synaptic depression. [PDF]

PLoS ONE, 2013
Neuronal circuits modify their response to synaptic inputs in an experience-dependent fashion. Increases in synaptic weights are accompanied by structural modifications, and activity dependent, long lasting growth of dendritic spines requires new protein
Yazmín Ramiro-Cortés, Inbal Israely
doaj   +1 more source

Synaptic Function of Rab11Fip5: Selective Requirement for Hippocampal Long-Term Depression [PDF]

The Journal of Neuroscience, 2015
Postsynaptic AMPA-type glutamate receptors (AMPARs) are among the major determinants of synaptic strength and can be trafficked into and out of synapses. Neuronal activity regulates AMPAR trafficking during synaptic plasticity to induce long-term changes in synaptic strength, including long-term potentiation (LTP) and long-term depression (LTD).
Taulant Bacaj, Mohiuddin Ahmad, Sandra Jurado, Robert C. Malenka, Thomas C. Südhof   +4 more
openaire   +2 more sources

A single amino acid difference between the intracellular domains of amyloid precursor protein and amyloid-like precursor protein 2 enables induction of synaptic depression and block of long-term potentiation

Neurobiology of Disease, 2016
Alzheimer disease (AD) is initially characterized as a disease of the synapse that affects synaptic transmission and synaptic plasticity. While amyloid-beta and tau have been traditionally implicated in causing AD, recent studies suggest that other ...
Emilie Trillaud-Doppia, Nicolas Paradis-Isler, Jannic Boehm   +2 more
doaj   +1 more source