Results 31 to 40 of about 72,066 (264)

Interleukin‐1β abrogates long‐term depression of hippocampal CA1 synaptic transmission [PDF]

open access: yesSynapse, 2002
AbstractAlthough interleukin‐1β (IL‐1β) is well known to modulate synaptic transmission and plasticity of the hippocampus, no study has yet evaluated how this cytokine affects long‐term depression (LTD), one of the major forms of hippocampal synaptic plasticity.
Yuji, Ikegaya   +4 more
openaire   +2 more sources

Long-Term Depression of Excitatory Synaptic Transmission in the Rat Amygdala [PDF]

open access: yesThe Journal of Neuroscience, 1999
In view of the fact that both kindling and fear-potentiated startle are expressed by long-term enhancement of synaptic transmission in the amygdala, synaptic plasticity in this area of the brain is of particular importance. Here, we show for the first time that low-frequency stimulation of the lateral nucleus at 1 Hz for 15 min elicited a long-term ...
S J, Wang, P W, Gean
openaire   +2 more sources

Long-term synaptic depression in the striatum: physiological and pharmacological characterization [PDF]

open access: yesThe Journal of Neuroscience, 1992
The effect of tetanic activation of corticostriatal glutamatergic fibers was studied in striatal slices by utilizing extracellular and intracellular recording techniques. Tetanic stimulation produced a long- term synaptic depression (LTD) (> 2 h) of both extracellularly recorded field potentials and intracellularly recorded EPSPs.
CALABRESI, PAOLO   +4 more
openaire   +5 more sources

Modelling the influence of short term depression in vesicle release and stochastic calcium channel gating on auditory nerve spontaneous firing statistics

open access: yesFrontiers in Computational Neuroscience, 2014
We propose several modifications to an existing computational model of stochastic vesicle release in inner hair cell ribbon synapses, with the aim of producing simulated auditory nerve fibre spiking data that more closely matches empirical data ...
Bahar eMoezzi   +2 more
doaj   +1 more source

Relief of Synaptic Depression Produces Long-Term Enhancement in Thalamocortical Networks [PDF]

open access: yesJournal of Neurophysiology, 2006
Thalamocortical synapses may be able to undergo activity-dependent long-term changes in efficacy, such as long-term potentiation. Indeed, studies conducted in vivo have found that theta-burst stimulation (TBS) of the thalamus induces a long-term enhancement (LTE) of field potential responses evoked in the neocortex of adult rodents.
Akio, Hirata, Manuel A, Castro-Alamancos
openaire   +2 more sources

Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum

open access: yesNeural Plasticity, 2015
In the cerebellar molecular layer parallel fibre terminals release glutamate from both the active zone and from extrasynaptic “ectopic” sites. Ectopic release mediates transmission to the Bergmann glia that ensheathe the synapse, activating Ca2 ...
Katharine L. Dobson, Tomas C. Bellamy
doaj   +1 more source

Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens [PDF]

open access: yesProceedings of the National Academy of Sciences, 2002
Do endocannabinoids (eCBs) participate in long-term synaptic plasticity in the brain? Using pharmacological approaches and genetically altered mice, we show that stimulation of prelimbic cortex afferents at naturally occurring frequencies causes a long-term depression of nucleus accumbens glutamatergic synapses mediated by eCB release and ...
David, Robbe   +4 more
openaire   +2 more sources

Bio-inspired artificial synapse for neuromorphic computing based on NiO nanoparticle thin film

open access: yesScientific Reports, 2023
The unprecedented need for data processing in the modern technological era has created opportunities in neuromorphic devices and computation. This is primarily due to the extensive parallel processing done in our human brain.
Keval Hadiyal   +3 more
doaj   +1 more source

Long-term synaptic depression in the mammalian brain

open access: yesNeuron, 1994
A generally accepted hypothesis in neurobiology has been that at the cellular level, memories are stored, at least in part, as long-term alterations in the strength of synaptic tranmission. In recent years, considerable attention has been paid to persistent, use-dependent mechanisms that increase synaptic strength, which are collectively referred to as
openaire   +2 more sources

Long-Term Depression of Intrinsic Excitability Accompanied by Synaptic Depression in Cerebellar Purkinje Cells [PDF]

open access: yesThe Journal of Neuroscience, 2017
Long-term depression (LTD) at the parallel fiber (PF)-to-cerebellar Purkinje cell (PC) synapse is implicated in the output of PCs, the sole output of the cerebellar cortex. In addition to synaptic plasticity, intrinsic excitability is also one of the components that determines PC output. Although long-term potentiation of intrinsic excitability (LTP-IE)
Hyun Geun Shim   +7 more
openaire   +2 more sources

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