Detection of aneuploidy in patients with cancer through amplification of long interspersed nucleotide elements (LINEs). [PDF]
Proc Natl Acad Sci U S A, 2018 Aneuploidy is a feature of most cancer cells, and a myriad of approaches have been developed to detect it in clinical samples. We previously described primers that could be used to amplify ∼38,000 unique long interspersed nucleotide elements (LINEs) from throughout the genome.
Douville C +9 more
europepmc +4 more sources
Tumor Long Interspersed Nucleotide Element-1 (LINE-1) Hypomethylation in Relation to Age of Colorectal Cancer Diagnosis and Prognosis [PDF]
Cancers, 2021 Evidence indicates the pathogenic role of epigenetic alterations in early-onset colorectal cancers diagnosed before age 50. However, features of colorectal cancers diagnosed at age 50–54 (hereafter referred to as “intermediate-onset”) remain less known.
Naohiko Akimoto +21 more
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Transposable Elements: No More 'Junk DNA' [PDF]
Genomics & Informatics, 2012 Since the advent of whole-genome sequencing, transposable elements (TEs), just thought to be 'junk' DNA, have been noticed because of their numerous copies in various eukaryotic genomes.
Yun-Ji Kim, Jungnam Lee, Kyudong Han
doaj +1 more source
Endogenous Double-Stranded RNA
Non-Coding RNA, 2021 The birth of long non-coding RNAs (lncRNAs) is closely associated with the presence and activation of repetitive elements in the genome. The transcription of endogenous retroviruses as well as long and short interspersed elements is not only essential ...
Shaymaa Sadeq +3 more
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Scientific Reports, 2022 Long interspersed nucleotide element-1 (LINE-1) and Alu elements are retrotransposons whose abilities cause abnormal gene expression and genomic instability.
Thanit Saeliw +7 more
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Relation between hypomethylation of long interspersed nucleotide elements and risk of neural tube defects [PDF]
The American Journal of Clinical Nutrition, 2010 Impaired one-carbon metabolism is thought to be associated with the risk of neural tube defects (NTDs); however, the role of methylation in NTDs remains unclear. Long interspersed nucleotide element-1 (LINE-1) constitutes 17-25% of the human genome. LINE-1 hypomethylation correlates with global DNA methylation levels in cancerous cells, but limited ...
Li, Wang +9 more
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Retrotransposon long interspersed nucleotide element‐1 (LINE‐1) is activated during salamander limb regeneration [PDF]
Development, Growth & Differentiation, 2012 Salamanders possess an extraordinary capacity for tissue and organ regeneration when compared to mammals. In our effort to characterize the unique transcriptional fingerprint emerging during the early phase of salamander limb regeneration, we identified transcriptional activation of some germline‐specific genes within the Mexican axolotl (Ambystoma ...
Wei, Zhu +9 more
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PLoS ONE, 2021 Highly methylated Long Interspersed Nucleotide Elements 1 (LINE-1) constitute approximately 20% of the human genome, thus serving as a surrogate marker of global genomic DNA methylation.
Duong Anh Thuy Pham +6 more
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Prognostic and predictive significance of long interspersed nucleotide element-1 methylation in advanced-stage colorectal cancer [PDF]
BMC Cancer, 2016 Hypomethylation of Long Interspersed Nucleotide Element-1 (LINE-1) is associated with worse prognosis in colorectal cancer (CRC). However, little is known about the relevance of this marker for the prognosis and response to chemotherapy of metastatic and recurrent (advanced-stage) CRC.
Kaneko, Mami +5 more
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Methylation levels of the "long interspersed nucleotide element-1" repetitive sequences predict survival of melanoma patients [PDF]
Journal of Translational Medicine, 2011 AbstractBackgroundThe prognosis of cutaneous melanoma (CM) differs for patients with identical clinico-pathological stage, and no molecular markers discriminating the prognosis of stage III individuals have been established. Genome-wide alterations in DNA methylation are a common event in cancer.
Sigalotti L +9 more
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