Results 251 to 260 of about 614,602 (305)

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Long non-coding RNA LINC00607 epigenetically regulates endothelial TSPAN18 to promote hypoxia-induced thromboinflammation. [PDF]

J Biol Chem
Khan MY, Singh K, Hashmi A, Sultan A, Sadia K, Ashraf MZ.   +5 more
europepmc   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Advances of Long Non-Coding RNA in Perennial Plants: Development and Stress Responses. [PDF]

Plants (Basel)
Guo Y, Guo D, Wang Y, Yin J, Liu G, Xu H.   +5 more
europepmc   +1 more source

Long non-coding RNA in hepatocellular carcinoma: mechanistic insights and therapeutic perspectives. [PDF]

Cell Oncol (Dordr)
Yu K, Jin Y, Zhou Y, Xu Q.
europepmc   +1 more source

Inhibition of radiotherapy sensitivity in nasopharyngeal carcinoma via the long non-coding RNA <i>RHPN1-AS1</i>. [PDF]

Transl Cancer Res
Jiang J, Wang D, Kang M, Qian Y, Zha T, Shao CS.   +5 more
europepmc   +1 more source

Engineering exosomes with iRGD for targeted RNAi therapy against pancreatic cancer mediated by long non-coding RNA PLBD1-AS1. [PDF]

PLoS One
Zhu W, Zhao X, Hao W, Zhou X, Ma C, Chen J, Zhao Y, Kong X, Du Y, Li L.   +9 more
europepmc   +1 more source

Downregulation of the Long Non-Coding RNA <i>MDL1AS</i> Alters Metabolism, Differentiation, and Radiosensitivity in NTERA2 and SH-SY5Y Cells. [PDF]

Cancers (Basel)
Casas-Benito A, Garrido P, Martínez A.
europepmc   +1 more source

Statement of Retraction: Exosomal long non-coding RNA-LINC00839 promotes lung adenocarcinoma progression by activating NF-κB signaling pathway. [PDF]

Ann Med
europepmc   +1 more source