Results 31 to 40 of about 739,569 (400)

Long Non-Coding RNA in the Pathogenesis of Cancers

Cells, 2019
The incidence and mortality rate of cancer has been quickly increasing in the past decades. At present, cancer has become the leading cause of death worldwide. Most of the cancers cannot be effectively diagnosed at the early stage.
Yujing Chi, Di Wang, Junpei Wang, Weidong Yu, Jichun Yang   +4 more
semanticscholar   +1 more source

Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling

EMBO Molecular Medicine, 2016
The nervous and vascular systems, although functionally different, share many common regulators of function maintenance. Long non‐coding RNAs (lncRNAs) are important players in many biological processes and human disorders.
Jin Yao, Xiao‐Qun Wang, Yu‐Jie Li, Kun Shan, Hong Yang, Yang‐Ning‐Zhi Wang, Mu‐Di Yao, Chang Liu, Xiu‐Miao Li, Yi Shen, Jing‐Yu Liu, Hong Cheng, Jun Yuan, Yang‐Yang Zhang, Qin Jiang, Biao Yan   +15 more
doaj   +2 more sources

NONCODEV6: an updated database dedicated to long non-coding RNA annotation in both animals and plants

Nucleic Acids Res., 2020
NONCODE (http://www.noncode.org/) is a comprehensive database of collection and annotation of noncoding RNAs, especially long non-coding RNAs (lncRNAs) in animals.
Lianhe Zhao, Jiajia Wang, Yanyan Li, Tingrui Song, Yang Wu, Shuangsang Fang, Dechao Bu, Hui Li, Liang Sun, D. Pei, Yu Zheng, Jianqin Huang, Mingqing Xu, Runsheng Chen, Yi Zhao, Shunmin He   +15 more
semanticscholar   +1 more source

MicroRNA-encoding long non-coding RNAs [PDF]

BMC Genomics, 2008
Abstract Background Recent analysis of the mouse transcriptional data has revealed the existence of ~34,000 messenger-like non-coding RNAs (ml-ncRNAs). Whereas the functional properties of these ml-ncRNAs are beginning to be unravelled, no functional information is available for the large majority of these transcripts.
Zhu Xiaopeng, He Dandan, He Housheng, Skogerbø Geir, Liu Changning, Su Hua, He Shunmin, Liu Tao, Zhao Yi, Chen Runsheng   +9 more
openaire   +3 more sources

Integrative analyses of transcriptome sequencing identify novel functional lncRNAs in esophageal squamous cell carcinoma. [PDF]

, 2017
Long non-coding RNAs (lncRNAs) have a critical role in cancer initiation and progression, and thus may mediate oncogenic or tumor suppressing effects, as well as be a new class of cancer therapeutic targets. We performed high-throughput sequencing of RNA
Ai, B, Bai, X-F, Cao, H-H, Feng, C-C, He, J-Z, Huang, G-W, Koeffler, HP, Lei, F, Li, C-Q, Li, E-M, Li, M, Li, S, Li, X, Li, X-C, Liao, L-D, Lin, D-C, Liu, Y-J, Shen, J-H, Tang, Z-D, Wang, L-D, Wang, M-R, Wang, Q-Y, Wang, S-H, Wu, B-L, Wu, J-Y, Wu, Z-Y, Xu, L-Y, Xu, Y-J, Xue, Y-J, Zhang, J, Zhao, J-M, Zheng, C-P, Zhu, Y   +32 more
core   +1 more source

Exosomal transfer of long non-coding RNA SBF2-AS1 enhances chemoresistance to temozolomide in glioblastoma

Journal of experimental & clinical cancer research : CR, 2019
Acquired drug resistance is a constraining factor in clinical treatment of glioblastoma (GBM). However, the mechanisms of chemoresponsive tumors acquire therapeutic resistance remain poorly understood.
Zhuoran Zhang, Jianxin Yin, Chenfei Lu, Yutian Wei, Ailiang Zeng, Y. You   +5 more
semanticscholar   +1 more source

Long non‐coding RNAs in melanoma [PDF]

Cell Proliferation, 2018
AbstractMelanoma is the most lethal cutaneous cancer with a highly aggressive and metastatic phenotype. While recent genetic and epigenetic studies have shed new insights into the mechanism of melanoma development, the involvement of regulatory non‐coding RNAs remain unclear.
Xin Yu, Heyi Zheng, Gary Tse, Matthew TV Chan, William KK Wu   +4 more
openaire   +2 more sources

Long non-coding RNA deregulation in tongue squamous cell carcinoma [PDF]

, 2014
Background. The deregulated tumorigenic long non-coding RNA (lncRNA) has been reported in several malignancies. However, there is still no comprehensive study on tongue squamous cell carcinoma (SCC). Methods.
Chan, JYW, Gao, W, Wong, TS
core   +8 more sources

A novel long non-coding natural antisense RNA is a negative regulator of Nos1 gene expression [PDF]

, 2015
Long non-coding natural antisense transcripts (NATs) are widespread in eukaryotic species. Although recent studies indicate that long NATs are engaged in the regulation of gene expression, the precise functional roles of the vast majority of them are ...
AC Thénié, B Holmqvist, B Kuzin, B Moreno-Lopez, BL Sopher, C-H Cheng, D Dahary, DS Bredt, E Ciani, E Pavesi, GB Robb, J Chen, J Garthwaite, J-T Li, JB Kelley, JE Fish, JH Brann, K Matsui, KY Kwan, L Zhou, MA Faghihi, MA Packer, ME Evangelopoulos, ME Evangelopoulos, MHT Ling, N Peunova, P Ogilvie, RG Tremblay, S Hindley, S Korneev, SA Korneev, SA Korneev, SA Korneev, SA Korneev, SM Gibbs, SR Vincent, U Forstermann, V Calabrese, Y Zhang   +38 more
core   +1 more source

LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases

Nucleic Acids Res., 2018
Mounting evidence suggested that dysfunction of long non-coding RNAs (lncRNAs) is involved in a wide variety of diseases. A knowledgebase with systematic collection and curation of lncRNA-disease associations is critically important for further examining
Zhenyu Bao, Zhen Yang, Zhou Huang, Yiran Zhou, Qinghua Cui, Dong Dong   +5 more
semanticscholar   +1 more source