Results 31 to 40 of about 588,548 (249)
Long non-coding RNAs in cancer progression [PDF]
Frontiers in Genetics, 2012 Recent large-scale transcriptome analyses have revealed that transcription is spread throughout the mammalian genomes, yielding large numbers of transcripts, including long non-coding RNAs (lncRNAs) with little or no protein-coding capacity. Dozens of lncRNAs have been identified as biologically significant.
Nobuyoshi Akimitsu, Keiko Tano
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Non-coding RNAs in skin cancers: An update [PDF]
, 2016 Skin cancers are the most common form of cancer in humans. They can largely be categorized into Melanoma and Non-melanoma skin cancers. The latter mainly includes Squamous Cell Carcinoma (SCC) and Basal Cell Carcinoma (BCC), and have a higher incidence ...
Kaushik, Nitin, Kaushik, Shivani B.
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Regulation of metabolism by long, non-coding RNAs [PDF]
Frontiers in Genetics, 2014 Our understanding of genomic regulation was revolutionized by the discovery that the genome is pervasively transcribed, giving rise to thousands of mostly uncharacterized non-coding ribonucleic acids (ncRNAs). Long, ncRNAs (lncRNAs) have thus emerged as a novel class of functional RNAs that impinge on gene regulation by a broad spectrum of mechanisms ...
Jens C. Brüning, Jan-Wilhelm Kornfeld
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Therapeutic role of long non-coding RNA TCONS_00019174 in depressive disorders is dependent on Wnt/$\beta$-catenin signaling pathway [PDF]
Journal of Integrative Neuroscience, 2018 Chronic stress is one of the major causes that lead to major depressive disorder, which is a prevalent mood disorder worldwide. Many patients with major depressive disorder do not benefit from available medication due to the complex etiology of the ...
Xinqiang Ni, Yingzhao Liao, Limin Li, Xiaoli Zhang, Zhengzhi Wu
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Lithium alters expression of RNAs in a type-specific manner in differentiated human neuroblastoma neuronal cultures, including specific genes involved in Alzheimer's disease. [PDF]
, 2019 Lithium (Li) is a medication long-used to treat bipolar disorder. It is currently under investigation for multiple nervous system disorders, including Alzheimer's disease (AD).
Balaraman, Yokesh +7 more
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Long non-coding RNAs in osteosarcoma
Oncotarget, 2017 Long non-coding RNAs (lncRNAs) with more than 200 nuleotides, have been explored to participate in various cancer types including osteosarcoma (OS), which is the most common kind of primary bone tumors with high morbidity in infants and adolescents.
Yingqi Hua +4 more
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Long non-coding RNA and diseases [PDF]
Jichu yixue yu linchuangLong non-coding RNA (lncRNA) is a class of endogenous non-coding RNA with a length of more than 200 nt. Due to lack of open reading frame (ORF), they lack the ability to directly encode proteins, but they play a crucial role in gene regulation.
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Long Non-Coding RNAs in Neuronal Aging [PDF]
Non-Coding RNA, 2018 The expansion of long non-coding RNAs (lncRNAs) in organismal genomes has been associated with the emergence of sophisticated regulatory networks that may have contributed to more complex neuronal processes, such as higher-order cognition. In line with the important roles of lncRNAs in the normal functioning of the human brain, dysregulation of lncRNA ...
Pereira Fernandes, D. +3 more
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Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers [PDF]
, 2012 Background: Molecular characterization of tumors has been critical for identifying important genes in cancer biology and for improving tumor classification and diagnosis.
Beck, Andrew H +18 more
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The Role of Long Non-Coding RNAs in Hepatocarcinogenesis [PDF]
International Journal of Molecular Sciences, 2018 Whole-transcriptome analyses have revealed that a large proportion of the human genome is transcribed in non-protein-coding transcripts, designated as long non-coding RNAs (lncRNAs). Rather than being “transcriptional noise”, increasing evidence indicates that lncRNAs are key players in the regulation of many biological processes, including ...
Luigi Terracciano +5 more
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