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Long non-coding RNAs in retinoblastoma
Pathology - Research and Practice, 2019Retinoblastoma represents 3% of all childhood cancers and is the most common intraocular malignant tumor with a highly aggressive and metastatic phenotype. While recent genetic and epigenetic studies have reported new insights into the mechanism of retinoblastoma development, the involvement of regulatory non-coding RNAs remains unclear.
Ming, Yang, Wenbin, Wei
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2011
Long non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. Based on genome-wide studies, more than 3, 300 of them exist, but to date only the limited number of functional lncRNAs have been identified and ...
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Long non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. Based on genome-wide studies, more than 3, 300 of them exist, but to date only the limited number of functional lncRNAs have been identified and ...
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Long non-coding RNA HCP5 in cancer
Clinica Chimica Acta, 2021Cancer remains a major threat to human health worldwide. Long non-coding RNA (lncRNA) comprises a group of single-stranded RNA with lengths longer than 200 bp. LncRNAs are aberrantly expressed and play a variety of roles involving multiple cellular processes in cancer.
Yuanzhang Zou, Binghai Chen
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“Going Long”: Long Non-Coding RNAs as Biomarkers
Circulation Research, 2014Protein-coding sequences constitute 200 nucleotides). Since their discovery in 2001, miRNAs have been studied extensively and fundamental insights have been obtained about their synthesis, their repression of target genes, and their involvement in disease processes. Indeed, miRNA therapeutics are already tested in clinical trials. Article, see p 668
Philipp, Skroblin, Manuel, Mayr
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Long non-coding RNAs in schizophrenia
Clinica Chimica ActaLong noncoding RNAs (lncRNAs) have emerged as critical regulators of the pathogenesis of schizophrenia, a complex neuropsychiatric disorder influenced by genetic and environmental factors. These transcripts modulate gene expression through diverse mechanisms, including chromatin remodeling, transcriptional regulation, and posttranscriptional ...
Seyyed Navid, Mousavinejad +6 more
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Long non-coding RNA molecules in tuberculosis
International Journal of Biological Macromolecules, 2020Tuberculosis (TB), a chronic disease caused by Mycobacterium tuberculosis, is one of the deadliest infectious diseases in the world. Despite significant advances in detection techniques and therapeutic approaches for tuberculosis, there is still no suitable solution for early screening and reducing the number of individuals affected and their effective
Hadis, Fathizadeh +6 more
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Long non-coding RNA PVT1 and cancer
Biochemical and Biophysical Research Communications, 2016Genome-wide sequencing technologies have led to the identification of many non-coding RNAs and revealed an important role for these molecules in cancer. Although there have been many studies on the role of short non-coding RNAs in cancer, much work remains to characterize the functions of long non-coding RNAs. PVT1, a long non-coding RNA encoded by the
Ming, Cui +5 more
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Long non-coding RNAs in coronary atherosclerosis
Life Sciences, 2018Coronary atherosclerosis (CAS), a leading cause of cardiovascular disease, is a major cause of death worldwide. CAS is a chronic disease in the aorta that can be caused by dyslipidemia, abnormal glucose metabolism, endothelial cell dysfunction, vascular smooth muscle cell (VSMC) or fibrous connective tissue hyperplasia, immune inflammatory reactions ...
Yiran, Wang +3 more
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Long non-coding RNAs: definitions, functions, challenges and recommendations
Nature Reviews Molecular Cell Biology, 2023John S Mattick +2 more
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Non-coding RNAs in disease: from mechanisms to therapeutics
Nature Reviews Genetics, 2023Kinga Nemeth +2 more
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