Results 41 to 50 of about 6,663,585 (252)

Competing Endogenous RNA Networks Reveal Long Non-coding RNAs as Potential Prognostic Biomarkers in Gastric Cancer: A Systematic Review and Meta-Analysis

Advanced Biomedical Research
Background: Gastric cancer (GC) represents a global healthcare challenge. Recently, many competing endogenous RNA (ceRNA) network studies have elucidated critical long noncoding RNAs (lncRNAs) as potential prognostic biomarkers in GC.
Sadra Salehi-Mazandarani, Mohammad Hossein Donyavi, Amirhossein Vedaei, Alireza Najimi, Ziba Farajzadegan, Parvaneh Nikpour   +5 more
doaj   +1 more source

The roles of long noncoding RNAs in the regulation of OCT4 expression

Stem Cell Research & Therapy, 2022
OCT4 is a major transcription factor that maintains the pluripotency of stem cells, including embryonic stem cells, induced pluripotent stem cells and cancer stem cells. An increasing number of long noncoding RNAs have been reported to participate in the
Rui-Ting Zhou, Yi-Ran Ni, Fan-Jun Zeng
doaj   +1 more source

Long noncoding RNAs in viral infections

, 2016
Viral infections induce strong modifications in the cell transcriptome. Among the RNAs whose expression is altered by infection are long noncoding RNAs (lncRNAs). LncRNAs are transcripts with potential to function as RNA molecules.
Morris, Kevin V, Fortes, Puri
core   +1 more source

Altered extracellular matrix remodeling accompanies decreased lncRNA HOTAIR expression in Takayasu arteritis

Frontiers in Immunology
ObjectivesTakayasu arteritis (TAK) is a large-vessel vasculitis characterized by chronic vascular inflammation and extracellular matrix (ECM) remodeling.
Fernanda Espinosa-Bautista, María G. Soberanes-García, Diana Castillo-Martínez, Rashidi Springall, Adrián Hernández-Díazcouder, Luis M. Amezcua-Guerra, Luis M. Amezcua-Guerra, Luis M. Amezcua-Guerra   +7 more
doaj   +1 more source

Transcriptional network modulated by the prognostic signature transcription factors and their long noncoding RNA partners in primary prostate cancer

EBioMedicine, 2021
Background: Transcriptional regulators are seminal players in the onset and progression of prostate cancer. However, clarification of their underlying regulatory circuits and mechanisms demands considerable effort.
Mei Jiang, Yihang Cheng, Dan Wang, Yali Lu, Shaohua Gu, Chenji Wang, Yan Huang, Yao Li   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

MicroRNA-encoding long non-coding RNAs

BMC Genomics, 2008
Background Recent analysis of the mouse transcriptional data has revealed the existence of ~34,000 messenger-like non-coding RNAs (ml-ncRNAs). Whereas the functional properties of these ml-ncRNAs are beginning to be unravelled, no functional information ...
Zhu Xiaopeng, He Dandan, He Housheng, Skogerbø Geir, Liu Changning, Su Hua, He Shunmin, Liu Tao, Zhao Yi, Chen Runsheng   +9 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Benchmarking tools for the alignment of functional noncoding DNA [PDF]

, 2004
Pollard DA, Bergman CM, Stoye J, Celniker SE, Eisen MB. Benchmarking tools for the alignment of functional noncoding DNA. BMC Bioinformatics. 2004;5(1): 6.Background: Numerous tools have been developed to align genomic sequences.
Celniker SE, Eisen MB, MB Eisen, Stoye J, Bergman CM, Celniker, Susan E., Bergman, Casey M., SE Celniker, Pollard, Daniel A., Pollard DA, CM Bergman, Eisen, Michael B., J Stoye, Stoye, Jens, Stoye, Jens ; https://orcid.org/, DA Pollard   +15 more
core   +5 more sources