Results 51 to 60 of about 6,663,585 (252)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

High-throughput annotation of full-length long noncoding RNAs with capture long-read sequencing [PDF]

, 2017
Accurate annotation of genes and their transcripts is a foundation of genomics, but currently no annotation technique combines throughput and accuracy.
Abad, Amaya, Barbara Uszczynska-Ratajczak, Thomas R Gingeras, Lagarde, J., Sílvia Pérez-Lluch, Gingeras, Thomas R, Lagarde, Julien, Johnson, R., Jennifer Harrow, Uszczynska-Ratajczak, Barbara, Silvia Carbonell, Guigó Serra, Roderic, Gingeras, T. R., Amaya Abad, Frankish, Adam, Davis, C., Uszczynska-Ratajczak, B., Frankish, A., Carrie Davis, Pérez-Lluch, Sílvia, Gingeras, Thomas R., Adam Frankish, Perez-Lluch, S., Guigo, R., Julien Lagarde, Harrow, J., Carbonell, Silvia, Rory Johnson, Harrow, Jennifer, Davis, Carrie, Johnson, Rory, Guigo, Roderic, Roderic Guigo, Carbonell, S., Davis, Carrie A., Abad, A.   +35 more
core   +3 more sources

Cholangiopathies and the noncoding revolution

, 2022
Noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) among others, have attracted a great deal of attention for their potential role as master regulators of gene expression and as therapeutic targets.
Sergio Gradilone, Gradilone, Sergio, Piccolo, Pasquale, Pasquale Piccolo, Brunetti-Pierri, Nicola, Nicola Brunetti-Pierri   +5 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Potential Regulatory Roles of MicroRNAs and Long Noncoding RNAs in Anticancer Therapies

Molecular Therapy: Nucleic Acids, 2018
MicroRNAs and long noncoding RNAs have long been investigated due to their roles as diagnostic and prognostic biomarkers of cancers and regulators of tumorigenesis, and the potential regulatory roles of these molecules in anticancer therapies are ...
Mengyan Xie, Ling Ma, Tongpeng Xu, Yutian Pan, Qiang Wang, Yutian Wei, Yongqian Shu   +6 more
doaj   +1 more source

Known imprinted long noncoding genes found in this study.

, 2013
Known imprinted long noncoding genes found in this study.
Ji Wu (217440), Jin Sun (117866), Yi Lin (49406)   +2 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Noncoding RNAs: biology and applications-a Keystone Symposia report. [PDF]

, 2021
The human transcriptome contains many types of noncoding RNAs, which rival the number of protein-coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi-interacting RNAs (piRNAs) of only 20 nucleotides, noncoding ...
Pyle, Anna, Jennifer Cable, Henninger, Jonathan E., Mendell, Joshua T., Wilusz, Jeremy E, Juan Pablo Unfried, Sean E. McGeary, Xiaohua Shen, Prasanth, Kannanganattu, Kumar, Dhiraj, Samie R. Jaffrey, McGeary, Sean E, Unfried, Juan, He, Lin, Simon, Matthew, Maquat, Lynne E., Quinodoz, Sofia, Feinberg, Mark, Heard, Edith, Mendell, Joshua, Chuong, Edward B, Simon, Matthew D., Marcia, Marco, Chang, Howard, Tetsuro Hirose, Chun‐Kan Chen, Chuong, Edward B., Chen, Chun-Kan, Qi Chen, McGeary, Sean E., Edith Heard, Feinberg, Mark W., Jeremy E. Wilusz, Xuhang Liu, Diermeier, Sarah D, Spector, David, Mukesh Kumar Lalwani, Unfried, Juan Pablo, Lydia M. Contreras, Prasanth, Kannanganattu V., Spector, David L, Chen, Qi, Liu, Xuhang, Contreras, Lydia, Cable, Jennifer, Prasanth, Kannanganattu V, Chang, Howard Y, Chen, Ling‐Ling, Rinn, John L., Anna Marie Pyle, Erwei Song, Hargrove, Amanda E., Hargrove, Amanda E, Henninger, Jonathan E, Allison M. Porman, Sarah D. Diermeier, Porman, Allison M., Lin He, Song, Erwei, Murat Can Kalem, Henninger, Jonathan, Wahba, Lamia, Porman, Allison, Hirose, Tetsuro, Mendell, Joshua T, Lynne E. Maquat, Mark W. Feinberg, Contreras, Lydia M, Matthew D. Simon, Róża K. Przanowska, Maquat, Lynne E, Wilusz, Jeremy, Lalwani, Mukesh Kumar, Joshua T. Mendell, Przanowska, Róża, Edward B. Chuong, Chuong, Edward, Wilusz, Jeremy E., Johnson, Rory, Lalwani, Mukesh, Shen, Xiaohua, Sofia A. Quinodoz, Chang, Howard Y., Jaffrey, Samie R, Porman, Allison M, David L. Spector, Hargrove, Amanda, Spector, David L., Diermeier, Sarah D., Kannanganattu V. Prasanth, Maquat, Lynne, Quinodoz, Sofia A, Contreras, Lydia M., Quinodoz, Sofia A., Amanda E. Hargrove, Jonathan E. Henninger, Przanowska, Róża K., Przanowska, Róża K, Junchao Shi, John L. Rinn, Feinberg, Mark W, Diermeier, Sarah, Chen, Ling-Ling, McGeary, Sean, Lempradl, Adelheid, Shi, Junchao, Ling‐Ling Chen, Rinn, John L, Dhiraj Kumar, Kalem, Murat Can, Chen, Chun‐Kan, Lamia Wahba, Rory Johnson, Pyle, Anna Marie, Marco Marcia, Simon, Matthew D, Jaffrey, Samie, Howard Y. Chang, Rinn, John, Jaffrey, Samie R., Adelheid Lempradl, Kalem, Murat   +121 more
core   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source