LINC00467: an oncogenic long noncoding RNA
Cancer Cell International, 2022 Long non-coding RNAs (lncRNAs) have been found to play essential roles in the cell proliferation, fission and differentiation, involving various processes in humans.
Xuyu Chen +6 more
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Global Positioning System: Understanding Long Noncoding RNAs through Subcellular Localization. [PDF]
, 2019 The localization of long noncoding RNAs (lncRNAs) within the cell is the primary determinant of their molecular functions. LncRNAs are often thought of as chromatin-restricted regulators of gene transcription and chromatin structure.
Carlevaro-Fita, Joana +3 more
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Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Long Noncoding RNA: Genome Organization and Mechanism of Action
, 2017 For the last four decades, we have known that noncoding RNAs maintain critical housekeeping functions such as transcription, RNA processing, and translation.
Debosree Pal +5 more
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Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Noncoding RNAs Act as a Chromatin Scaffold of Histone Modification Complexes in Cancer
, 2018 Accumulating evidence suggests that several of the genomic mutations reside within the noncoding regions, thereby leading to profound impact on the genesis of various disease conditions, including cancer.
Chandrima Das +7 more
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Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells
FEBS Open Bio, EarlyView.Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley +1 more source
RUNX1-IT1 and AK026392.1 Long Non-Coding RNAs as Early Predictors of Acute Graft-Versus-Host Disease following Allogeneic Hematopoietic Stem Cell Transplantation in Acute Leukemia [PDF]
Caspian Journal of Internal MedicineBackground:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) offers curative potential for hematologic malignancies, yet acute graft-versus-host disease (aGVHD) remains a major complication.
Mahsa Dabir +4 more
doaj
Linc-ing long noncoding RNAs and enhancer function
, 2010 Enhancers are distal regulatory sequences that control gene expression in development. Ørom et al. now report in Cell that some long noncoding RNAs have functional properties of enhancers.
John S. Mattick, Mattick, John S.
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source