Results 81 to 90 of about 6,663,585 (252)
Noncoding elements in wheat defence response to fusarium head blight
Scientific ReportsWheat (Triticum aestivum L.) is a major source of global food security while various stressors, including biotic and abiotic factors, directly affect its production.
Tugdem Muslu +6 more
doaj +1 more source
Long noncoding RNAs usher in a new era in the biology of enhancers [PDF]
, 2013 Enhancer-associated long noncoding RNAs act over long distances and across chromosomes to activate transcription at distal promoters. Here, we address the latest advances made toward understanding the role of long noncoding RNA expression and the ...
Ørom, U. +3 more
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RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
Long noncoding RNAs and Alzheimer's disease
, 2016 Qiong Luo,1,2 Yinghui Chen1,2 1Department of Neurology, Jinshan Hospital, 2Department of Neurology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China Abstract: Long noncoding RNAs (lncRNAs) are typically defined as ...
Luo Q, Chen Y
core
Arthritis Care &Research, EarlyView.Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos +2 more
wiley +1 more source
Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, EarlyView.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
Linking Long Noncoding RNAs to Function
, 2013 Although the vast majority of the human genome is devoid of protein-coding capacity, we now know that amidst the “dark matter” are an estimated 10,000 to 200,000 long noncoding RNAs (lncRNAs). This Select highlights recent insights into the regulation of
core +1 more source
Advanced Science, EarlyView.The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang +12 more
wiley +1 more source
Role of Noncoding RNAs in Modulating Microglial Phenotype
Global Medical GeneticsMicroglia are immunocompetent cells that are present in the retina and central nervous system, and are involved in the development maintenance and immune functions in these systems.
Eiman Meer
doaj +1 more source
LONG-NONCODING RNAs in gastroesophageal cancers
Non-coding RNA Research, 2018 Despite continuing improvements in multimodal therapies, gastro-esophageal malignances remain widely prevalent in the population and is characterized by poor overall and disease-free survival rates. Due to the lack of understanding about the pathogenesis
Giuseppe Nicolò Fanelli +10 more
doaj +1 more source