Results 151 to 160 of about 103,326 (267)

Correction: A novel long noncoding RNA‑LOWEG is low expressed in gastric cancer and acts as a tumor suppressor by inhibiting cell invasion. [PDF]

J Cancer Res Clin Oncol
Zhao JH, Sun JX, Song YX, Chen XW, Yang YC, Ma B, Wang J, Gao P, Wang ZN.   +8 more
europepmc   +1 more source

It Takes Two to Tango: A Pluralist Account for Building Comprehensive Explanations in Human Evolution

American Anthropologist, EarlyView.
ABSTRACT The evolutionary study of human dispersal is a key topic in biological anthropology. However, recent research has revealed inconsistencies between molecular and anatomical data across different timescales and geographic regions. Despite increased interdisciplinary dialogue, these discordances are rarely analyzed in depth or interpreted for ...
Lumila Paula Menéndez, Sophie Veigl
wiley   +1 more source

A Bifunctional Small Molecule Degrader of the Long Noncoding RNA MALAT1 Triplex. [PDF]

Chemistry
Brega CAT, Craig BA, Mikutis S, Proctor RSJ, Vyborna Y, Ivey G, Eleftheriou M, Tzelepis K, Yang M, Parmar S, Bonet-Aleta J, Schneekloth JS, Bernardes GJL.   +12 more
europepmc   +1 more source

Genetic risk factors in Finnish patients with Fuchs endothelial corneal dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To study the genetic risk factors of Fuchs endothelial corneal dystrophy (FECD) in the Finnish population using hospital‐based and large biobank cohorts. Methods We genotyped a cohort of 107 Finnish patients with FECD for the primary associated genetic risk factor, the TCF4 (CTG)>50 expansion, and studied their clinical phenotype.
Inka‐Tuulevi Vähämäki, Annamari T. Immonen, Joel T. Rämö, Aino M. Jaakkola, Kari Krootila, Maria Kaukonen, FinnGen, Aarno Palotie, Hannes Lohi, Tero T. Kivelä, Joni A. Turunen   +10 more
wiley   +1 more source

Critical Assessment of a Structure-Based Pipeline for Targeting the Long Noncoding RNA MALAT1. [PDF]

J Chem Inf Model
Aguti R, Bernetti M, Elisi GM, Cavalli A, Masetti M.   +4 more
europepmc   +1 more source

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

Cancer Science, EarlyView.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang, Changyi Fan, Shiheng Chen, Tianyue Lu, Yuanyuan Li, Feng Du, Shanshan Wang   +6 more
wiley   +1 more source

The impact and potential mechanisms of long noncoding RNA ENST00000521141.1 on human white adipocyte differentiation. [PDF]

J Endocrinol
Wu Q, You L, Lin S, Yu T, Yin R, Ye X, Xu L, Liang H, Pang L.   +8 more
europepmc   +1 more source

Harnessing Metabolic Priming to Engineer Human Nucleus Pulposus Macromass Overcoming Scalability‐Phenotype Tradeoff

Cell Proliferation, EarlyView.
Human platelet lysate acts as a metabolic primer for hNPCs, enhancing fatty acid oxidation to drive proliferation while preserving phenotype. This enables construction of high‐quality, large‐size macromasses without necrotic defects, demonstrating exceptional efficacy in repairing degenerated discs in situ and providing a novel paradigm for ...
Yingbo Wang, Ou Hu, Jian Wu, Sha Huang, Peng Lin, Pulin Yan, Yangyang Li, Huaijian Jin, Yutong Wu, Jun Zhu, Jungang Pu, Bo Hu, Jian He, Yibo Gan, Peng Liu   +14 more
wiley   +1 more source

Exosomal Long Noncoding RNA H19 as a Biomarker and Therapeutic Target in Atrial Fibrillation. [PDF]

Int J Biol Sci
Kang JY, Mun D, Park M, Yoo G, Yun N, Joung B.   +5 more
europepmc   +1 more source

A Specific tRNA Half, 3'tiRNA‐GlyGCC, Regulates Hypoxic Pulmonary Artery Smooth Muscle Cell Proliferation via Myrf‐Mediated Endoplasmic Reticulum Stress

Cell Proliferation, EarlyView.
A schematic diagram illustrating how 3′tiRNA‐GlyGCC promotes the endoplasmic reticulum stress (ERS) and proliferation in hypoxic pulmonary artery smooth muscle cells (PASMCs) by inhibiting the expression of myelin regulatory factor (Myrf), ultimately leading to pulmonary hypertension (PH).
Lixin Zhang, Xiaoyu Guan, Xiangrui Zhu, Yingying Hao, Ya Xu, Hao Yuan, Danni Gao, Hongxia Du, Jiayu Li, Weiwei Cao, Cui Ma, Xiaoying Wang   +11 more
wiley   +1 more source