Results 181 to 190 of about 7,001,848 (253)

A Bifunctional Small Molecule Degrader of the Long Noncoding RNA MALAT1 Triplex. [PDF]

Chemistry
Brega CAT, Craig BA, Mikutis S, Proctor RSJ, Vyborna Y, Ivey G, Eleftheriou M, Tzelepis K, Yang M, Parmar S, Bonet-Aleta J, Schneekloth JS, Bernardes GJL.   +12 more
europepmc   +1 more source

Genetic Risk Meets the Intestinal Barrier

Immunology &Cell Biology, EarlyView.
Top: At increasing cellular resolution, the Alegbe et al. report that expression quantitative trait loci (eQTLs) are enriched in enhancer regions rather than promoters. They speculate that enhancer eQTLs only come into effect during certain cellular contexts, making them more tolerable. Bottom: Alegbe et al.
J. L. E. Tearle, K. R. James
wiley   +1 more source

Unmasking the Influence of Viral Micro‐RNAs on Host Immunity

Immunology &Cell Biology, EarlyView.
Viral micro‐RNAs are increasingly recognized as key modulators of host–virus interactions. They influence multiple immune functions, including antigen presentation, T‐cell activation, and cytokine signaling, while also tuning viral gene expression to promote persistence.
Riley J. K. Easton, Bernadette M. Saunders   +1 more
wiley   +1 more source

Correction: A novel long noncoding RNA‑LOWEG is low expressed in gastric cancer and acts as a tumor suppressor by inhibiting cell invasion. [PDF]

J Cancer Res Clin Oncol
Zhao JH, Sun JX, Song YX, Chen XW, Yang YC, Ma B, Wang J, Gao P, Wang ZN.   +8 more
europepmc   +1 more source

Critical Assessment of a Structure-Based Pipeline for Targeting the Long Noncoding RNA MALAT1. [PDF]

J Chem Inf Model
Aguti R, Bernetti M, Elisi GM, Cavalli A, Masetti M.   +4 more
europepmc   +1 more source

Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance

Immunology, EarlyView.
Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos, Vitor Marcel Faça, Eduardo Antonio Donadi, Ana Paula Masson, Carlos Crippa Coletto, Gustavo Ronconi Roza   +5 more
wiley   +1 more source

The impact and potential mechanisms of long noncoding RNA ENST00000521141.1 on human white adipocyte differentiation. [PDF]

J Endocrinol
Wu Q, You L, Lin S, Yu T, Yin R, Ye X, Xu L, Liang H, Pang L.   +8 more
europepmc   +1 more source

Noncoding RNAs as novel diagnostic biomarkers for diabetic retinopathy: A systematic review and meta‐analysis

Journal of Diabetes Investigation, EarlyView.
The systematic review and meta‐analysis (Embase, PubMed, and Web of Science; up to August 2025) evaluated circulating noncoding RNAs (ncRNAs) as noninvasive early diagnostic biomarkers for diabetic retinopathy (DR). From 17 articles (24 studies, 1,983 DR patients vs 1,437 controls), a random‐effects model yielded pooled sensitivity of 0.81, specificity
Ting Zhang, Donghong Xu
wiley   +1 more source

Exosomal Long Noncoding RNA H19 as a Biomarker and Therapeutic Target in Atrial Fibrillation. [PDF]

Int J Biol Sci
Kang JY, Mun D, Park M, Yoo G, Yun N, Joung B.   +5 more
europepmc   +1 more source

The miR‐145‐5p/NRF2/SLC7A11 axis regulates ferroptosis‐mediated renal tubular epithelial cell injury in diabetic nephropathy

Journal of Diabetes Investigation, EarlyView.
Suppression of miR‐145‐5p alleviates DN‐associated renal tissue damage by inhibiting NRF2/SLC7A11‐mediated ferroptosis of RTECs. ABSTRACT Purpose This study aimed to investigate the molecular mechanism by which the miR‐145‐5p/NRF2/SLC7A11 axis regulates ferroptosis‐mediated renal tubular epithelial cell (RTEC) injury in diabetic nephropathy (DN ...
Ganlin Wu, Yu Fang, Meirong Xu, Zuopeng Lu, Yu Cao, Yana Gao   +5 more
wiley   +1 more source