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Long noncoding RNAs in osteoarthritis
Joint Bone Spine, 2017Osteoarthritis (OA) is the most common form of arthritis that may affect all joint tissues. Unfortunately, the pathogenesis of OA is not fully understood yet and it cannot be cured totally. Long noncoding RNA (lncRNA) is a type of RNA molecule greater than 200 nucleotides, and deregulated expression of lncRNAs plays an important role in many types of ...
Shi-de, Jiang +4 more
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Long Noncoding RNAs: An Overview
2016Recently an explosion in the discovery of long noncoding RNAs (lncRNAs) was obtained by high throughput sequencing. Genome-wide transcriptome analyses, in conjugation with research for epigenetic modifications of chromatins, identified a novel type of non-protein-coding transcripts longer than 200 nucleotides named lncRNAs.
Dongmei, Zhang +4 more
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Long noncoding RNAs in erythropoiesis
Blood, 2014In this issue of Blood, Alvarez-Dominguez et al use a combination of genomics technology, bioinformatics, and functional analyses to provide new insights into our understanding of the role of long noncoding RNAs (lncRNAs) in erythropoiesis.1 This is an initial step forward in our understanding of the many roles of lncRNAs in normal and perturbed ...
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NONCODEv4: Annotation of Noncoding RNAs with Emphasis on Long Noncoding RNAs
2016The rapid development of high-throughput sequencing technologies and bioinformatics algorithms now enables detection and profiling of a large number of noncoding transcripts. Long noncoding RNAs (lncRNAs), which are longer than 200 nucleotides, are accumulating with important roles involved in biological processes and tissue physiology. In this chapter,
Yi, Zhao, Jiao, Yuan, Runsheng, Chen
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Long Noncoding RNAs and Cancer
2015Long noncoding RNAs are an important class of RNAs that have been found to have diverse functions. Their discovery has stimulated a new area of cancer research and is providing new insights into chromatin regulation and transcriptional control. They have been implicated in a variety of cancers and have demonstrated their potential as diagnostic and ...
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Long Noncoding RNAs as Therapeutic Targets
2022Long noncoding RNAs (lncRNAs) have emerged as critical regulators of cellular functions including maintenance of cellular homeostasis as well as the onset and progression of disease. LncRNAs often exhibit cell-, tissue-, and disease-specific expression patterns, making them desirable therapeutic targets.
Jacob B, Pierce +3 more
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Long Noncoding RNAs and Cardiac Disease
Antioxidants & Redox Signaling, 2018Significance: To maintain homeostasis, gene expression has to be tightly regulated by complex and multiple mechanisms occurring at the epigenetic, transcriptional, and post-transcriptional levels. One crucial regulatory component is represented by long noncoding RNAs (lncRNAs), nonprotein-coding RNA species ...
Simona, Greco +3 more
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Long noncoding RNA regulation of immunity
Nature ImmunologyGenes encoding long noncoding RNAs (lncRNAs) are intimately involved in mammalian immunity. Here we review recent knowledge of how lncRNAs regulate immune cell specification and function. Beyond canonical roles in nuclear architecture, chromatin modification and posttranscriptional regulation, lncRNA regulation of metabolic pathways, antigenic ...
Bingfei Yu, Howard Y. Chang
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