Results 251 to 260 of about 7,947,893 (291)

Long-read Sequencing in Inherited Retinal Dystrophies: A Systematic Review. [PDF]

Ophthalmol Sci
Ibrahim M, Chebly A, El Shamieh S.
europepmc   +1 more source

Beyond counting: how single-cell long-read sequencing turns transcriptome complexity into precision targets. [PDF]

Front Oncol
Byrne A, Felton C, Stephenson W.
europepmc   +1 more source

Long-read sequencing of single cell-derived melanoma sublines reveals divergent and parallel genomic and epigenomic evolutionary trajectories. [PDF]

Nat Commun
Liu Y, Goretsky A, Keskus AG, Malikic S, Ahmad T, Gertz EM, Rashidi Mehrabadi F, Kelly M, Hernandez MO, Seibert C, Caravaca JM, Kline K, Zhao Y, Wu Y, Shrestha B, Tran B, Ghosh A, Cui X, Sassano A, Malik L, Baker B, Blauwendraat C, Billingsley KJ, Burkett S, Perez-Guijarro E, Merlino G, Molloy EK, Sahinalp SC, Day CP, Kolmogorov M.   +29 more
europepmc   +1 more source

Resolving eukaryotic river biofilm communities using long-read sequencing for biomonitoring

Anderson MAJ, Thorpe AC, Bhanu Busi S, Warren J, Walsh K, Read DS.   +5 more
europepmc   +1 more source

Targeted Long-Read sequencing provides functional validation of variants predicted to alter splicing

Quartesan I, Manini A, Schnekenberg RP, Facchini S, Curro R, Ghia A, Bertini A, Polke J, Bugiardini E, Munot P, O’Driscoll M, Laurá M, Sleigh JN, Reilly MM, Houlden H, Wood N, Cortese A.   +16 more
europepmc   +1 more source

Towards population-scale long-read sequencing [PDF]

Nature Reviews Genetics, 2021
: Long-read sequencing technologies have now reached a level of accuracy and yield that allows their application to variant detection at a scale of tens to thousands of samples.
Fritz Sedlazeck, M H Weissensteiner, Wouter de Coster   +2 more
exaly   +5 more sources

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Genomics in the long-read sequencing era

Trends in Genetics, 2023
Long-read sequencing (LRS) technologies have provided extremely powerful tools to explore genomes. While in the early years these methods suffered technical limitations, they have recently made significant progress in terms of read length, throughput, and accuracy and bioinformatics tools have strongly improved.
Claude Thermes, Yan Jaszczyszyn
exaly   +3 more sources

Iso-Seq Long Read Transcriptome Sequencing

2021
Isoform sequencing (Iso-Seq), a long-read transcriptome sequencing method developed by Pacific Biosciences, has the capacity to generate full-length transcripts without the need for assembly. The method facilitates better genome annotation, identification of alternative splicing events, novel transcript isoforms and epi-transcriptome modification which
Hoang, Nam V., Henry, Robert J.
openaire   +2 more sources

Efficient short-read sequencing on long-read sequencers

2020
We present SMURF-seq, a protocol to efficiently sequence short DNA molecules on a long-read sequencer by randomly ligating them to form long molecules. Applying SMURF-seq using the highly portable and inexpensive Oxford Nanopore MinION yields up to 30 fragments per read, providing an average of 6.2 and up to 7.5 million mappable fragments per run ...
openaire   +1 more source

Amplicon Sequencing using the Long-Read Sequencing Technologies

Journal of Visualized Experiments
The World Health Organization (WHO) continues to emphasize the urgent need for a rapid, cost-effective, and user-friendly diagnostic method for tuberculosis (TB) and drug-resistant TB (DR-TB). Next-generation sequencing (NGS) technologies, endorsed by the WHO, have significantly improved the detection of DR-TB.
Morwasehla, Modjadji, Brendon Coenrad, Mann, Johannes, Loubser, Jennifer, Williams, Janré, Steyn, Elizabeth Maria, Streicher, Melanie, Grobbelaar, Robin Mark, Warren   +7 more
openaire   +2 more sources