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Modeling Methylation Patterns with Long Read Sequencing Data
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2018Variation in cytosine methylation at CpG dinucleotides is often observed in genomic regions, and analysis typically focuses on estimating the proportion of methylated sites observed in a given region and comparing these levels across samples to determine association with conditions of interest.
Karlene Nicole Meyer, Michelle R. Lacey
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Long-read sequencing for rare human genetic diseases
Journal of Human Genetics, 2019During the past decade, the search for pathogenic mutations in rare human genetic diseases has involved huge efforts to sequence coding regions, or the entire genome, using massively parallel short-read sequencers. However, the approximate current diagnostic rate is
Satomi, Mitsuhashi, Naomichi, Matsumoto
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Long-read Sequencing Technology
This 50 minute lecture on long-read sequencing technology covers the following items: 1) Review of RNA-Seq Short-read Sequencing, 2) Overview and benefits of Long-read Sequencing, 3) Oxford Nanopore Sequencing, and 4) Pacific Biosciences Sequencing.openaire +1 more source
Genome sequencing: Long reads for a short plant
Nature Plants, 2015The genome of a tiny resurrection plant has been sequenced using PacBio's long-read single-molecule real-time sequencing technology, aiding the understanding of extreme desiccation tolerance. The genome contiguity is comparable to that of genomes sequenced using far more laborious approaches.
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Unveiling microbial diversity: harnessing long-read sequencing technology
Nature MethodsLong-read sequencing has recently transformed metagenomics, enhancing strain-level pathogen characterization, enabling accurate and complete metagenome-assembled genomes, and improving microbiome taxonomic classification and profiling. These advancements are not only due to improvements in sequencing accuracy, but also happening across rapidly changing
Daniel P. Agustinho +5 more
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Long‐Read Sequencing Could Increase Diagnosis Rates
American Journal of Medical Genetics Part A, 2021openaire +2 more sources
Ottelia alismoides long-read RNA sequenceing
This project sequenced Ottelia alismoides leaves RNA sequences under high and low CO2 treatments at dark and light conditions. Total RNA from two different treatments at two different times were mixed together for sequencing. There long-read sequences were used to provide gene sequences.openaire +1 more source