Results 81 to 90 of about 7,947,893 (291)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

High-throughput annotation of full-length long noncoding RNAs with capture long-read sequencing [PDF]

, 2017
Accurate annotation of genes and their transcripts is a foundation of genomics, but currently no annotation technique combines throughput and accuracy.
Abad, Amaya, Barbara Uszczynska-Ratajczak, Thomas R Gingeras, Lagarde, J., Sílvia Pérez-Lluch, Gingeras, Thomas R, Lagarde, Julien, Johnson, R., Jennifer Harrow, Uszczynska-Ratajczak, Barbara, Silvia Carbonell, Guigó Serra, Roderic, Gingeras, T. R., Amaya Abad, Frankish, Adam, Davis, C., Uszczynska-Ratajczak, B., Frankish, A., Carrie Davis, Pérez-Lluch, Sílvia, Gingeras, Thomas R., Adam Frankish, Perez-Lluch, S., Guigo, R., Julien Lagarde, Harrow, J., Carbonell, Silvia, Rory Johnson, Harrow, Jennifer, Davis, Carrie, Johnson, Rory, Guigo, Roderic, Roderic Guigo, Carbonell, S., Davis, Carrie A., Abad, A.   +35 more
core   +3 more sources

Detection of single nucleotide and copy number variants in the Fabry disease-associated GLA gene using nanopore sequencing

Scientific Reports, 2021
More than 900 variants have been described in the GLA gene. Some intronic variants and copy number variants in GLA can cause Fabry disease but will not be detected by classical Sanger sequence.
Albina Nowak, Omer Murik, Tzvia Mann, David A. Zeevi, Gheona Altarescu   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Scalable and cloud-enabled analysis of long read sequencing data [PDF]

, 2022
Thesis (Master's)--University of Washington, 2022Long-read sequencing has great promise in enabling portable, rapid molecular-assisted diagnoses. Applications of long-read sequencing include improved prognosis of critically ill patients through variant ...
Reddy, Shishir
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Gene Fusion Detection in Long-Read Transcriptome Datasets from Multiple Cancer Cell Lines

Frontiers in Bioscience-Landmark
Background: Fusion genes are important biomarkers in cancer research because their expression can produce abnormal proteins with oncogenic properties.
Keigo Masuda, Yoshiaki Sota, Hideo Matsuda   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

NanoGalaxy: Nanopore long-read sequencing data analysis in Galaxy [PDF]

, 2020
Background: Long-read sequencing can be applied to generate very long contigs and even completely assembled genomes at relatively low cost and with minimal sample preparation. As a result, long-read sequencing platforms are becoming more popular.
Mustafa, D.A.M. (Dana), Hiltemann, Saskia, Flemming, Stephan, Grüning, B., de Koning, Willem, Flemming, S, Hays, John; id_orcid, Beek, Marius van den, Mustafa, Dana A., Miladi, M., de Koning, W., Grüning, Björn, Hiltemann, S. (Saskia), Backofen, R., Hays, J.P. (John), Stubbs, Andrew, Hays, John P., Miladi, M, Heikema, Astrid, Miladi, Milad, Backofen, Rolf, Stubbs, A.P. (Andrew), Mustafa, Dana, de Koning, Willem; id_orcid, Beek, M. (Mike) van, van Beek, M, Backofen, R, Stubbs, Andrew P., Heikema, A.P. (Astrid), Flemming, S., Hays, John, Grüning, B   +31 more
core   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source