Results 91 to 100 of about 9,152,726 (291)

Long-read-based human genomic structural variation detection with cuteSV

, 2019
Long-read sequencing enables the comprehensive discovery of structural variations (SVs). However, it is still non-trivial to achieve high sensitivity and performance simultaneously due to the complex SV signatures implied by noisy long reads.
Jiang, Tao, Jiang, Tao (8215998)
core   +1 more source

Presentation_1_Oxford nanopore long-read sequencing enables the generation of complete bacterial and plasmid genomes without short-read sequencing.PDF

, 2023
IntroductionGenome-based analysis is crucial in monitoring antibiotic-resistant bacteria (ARB)and antibiotic-resistance genes (ARGs). Short-read sequencing is typically used to obtain incomplete draft genomes, while long-read sequencing can obtain ...
Wenxuan Zhao (4615180), Zhenpeng Li (553533), Ming Luo (13872), Jialiang Xu (1424821), Yao Peng (1928524), Xin Lu (24821), Bo Pang (164741), Wei Zeng (126658), Biao Kan (107255)   +8 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Table_1_Oxford nanopore long-read sequencing enables the generation of complete bacterial and plasmid genomes without short-read sequencing.DOCX

, 2023
IntroductionGenome-based analysis is crucial in monitoring antibiotic-resistant bacteria (ARB)and antibiotic-resistance genes (ARGs). Short-read sequencing is typically used to obtain incomplete draft genomes, while long-read sequencing can obtain ...
Wenxuan Zhao (4615180), Zhenpeng Li (553533), Ming Luo (13872), Jialiang Xu (1424821), Yao Peng (1928524), Xin Lu (24821), Bo Pang (164741), Wei Zeng (126658), Biao Kan (107255)   +8 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Expanding an expanded genome: long-read sequencing of Trypanosoma cruzi [PDF]

, 2018
Supporting data of the article 'Expanding an expanded genome: long-read sequencing of Trypanosoma cruzi,' as published in Microbial Genomics. DOI: 10.1099/mgen.0.000177
Fernando Alvarez-Valin, Gastón Rijo (5027948), Fernando Alvarez-Valin (5027954), Luisa Berná, Carlos Robello, Matias Rodriguez, Adriana Parodi-Talice, María Laura Chiribao (840672), Adriana Parodi-Talice (5027945), Sebastián Pita, Gastón Rijo, Luisa Berná (4288387), Sebastián Pita (3600737), Matías Rodríguez (5027951), Carlos Robello (238938), María Laura Chiribao, Parodi-Tálice, Adriana Magdalena, Berná, Luisa, Robello Porto, Carlos, Álvarez-Valín, Fernando, Chiribao, María Laura, Rodríguez, Matías A, Pita Mimbacas, Sebastián, Rijo, Gastón   +23 more
core   +1 more source

Long-Read Metagenomic Sequencing

Abstract This chapter describes the preparation of metagenomic DNA samples to produce long-read Oxford Nanopore-compatible libraries for shotgun whole-genome sequencing (WGS). This is of value for projects needing to assemble novel unculturable bacterial species and where higher resolution is required.
Dave Baker, Cara-Jane Moss
openaire   +1 more source

Multi-Platform Sequencing Approach Reveals a Novel Transcriptome Profile in Pseudorabies Virus

Frontiers in Microbiology, 2018
Third-generation sequencing is an emerging technology that is capable of solving several problems that earlier approaches were not able to, including the identification of transcripts isoforms and overlapping transcripts. In this study, we used long-read
Norbert Moldován, Dóra Tombácz, Attila Szűcs, Zsolt Csabai, Michael Snyder, Zsolt Boldogkői   +5 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source