Results 31 to 40 of about 169,643 (326)

Long Term Potentiation (LTP) and Long Term Depression (LTD) Cause Differential Spatial Redistribution of the Synaptic Vesicle Protein Synaptophysin in the Middle Molecular Layer of the Dentate Gyrus in Rat Hippocampus [PDF]

, 2016
The presynaptic modifications that accompany long-term changes in synaptic plasticity are still not fully understood. Synaptophysin is a major synaptic vesicle protein involved in neurotransmitter release. We have used quantitative electron microscopy to
Chaudhury, Sraboni, Dallérac, Glenn, Davies, Heather A., Doyère, Valérie, Kraev, Igor V., Stewart, Michael G.   +5 more
core   +1 more source

The α1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala

Frontiers in Behavioral Neuroscience, 2009
Synaptic plasticity in the amydgala is essential for emotional learning. Fear conditioning, for example, depends on changes in excitatory transmission that occur following NMDA receptor activation and AMPA receptor modification in this region. The role
Brian J Wiltgen, Brian J Wiltgen, Bill Godsil, Bill Godsil, Zechun Peng, Zechun Peng, Faysal Saab, Faysal Saab, Harry June, Michael L Van Linn, James M Cook, Carolyn Houser, Carolyn Houser, Thomas O’dell, Thomas O’dell, Gregg E Homanics, Michael Fanselow, Michael Fanselow   +17 more
doaj   +1 more source

Long Term Potentiation as a Mechanism for Learning and Memory [PDF]

Cell Journal, 2009
Since the 1970s when long term potentiation (LTP) was introduced to the scientific world;several studies have been devoted to determining whether this phenomenon is naturally abasic mechanism of learning and memory in mammalian brains. However, plenty of
Gholamali Hamidi, Sayyed Alireza Talaei Zavareh, Mahmoud Salami   +2 more
doaj  

Temporal sensitivity of protein kinase a activation in late-phase long term potentiation. [PDF]

PLoS Computational Biology, 2010
Protein kinases play critical roles in learning and memory and in long term potentiation (LTP), a form of synaptic plasticity. The induction of late-phase LTP (L-LTP) in the CA1 region of the hippocampus requires several kinases, including CaMKII and PKA,
MyungSook Kim, Ted Huang, Ted Abel, Kim T Blackwell   +3 more
doaj   +1 more source

Erythropoietin enhances hippocampal long-term potentiation and memory

BMC Biology, 2008
Background Erythropoietin (EPO) improves cognition of human subjects in the clinical setting by as yet unknown mechanisms. We developed a mouse model of robust cognitive improvement by EPO to obtain the first clues of how EPO influences cognition, and ...
El-Kordi Ahmed, Radyushkin Konstantin, Sperling Swetlana, Hannke Kathrin, Hassouna Imam, Müller Michael, Zhang Mingyue, Theis Fabian, Gertler Christoph, Medrihan Lucian, Stradomska Alicja, Sargin Derya, Adamcio Bartosz, Schulze Lizzy, Ronnenberg Anja, Wolf Fred, Brose Nils, Rhee Jeong-Seop, Zhang Weiqi, Ehrenreich Hannelore   +19 more
doaj   +1 more source

Long-term potentiation in frontal cortex: Role of NMDA-modulated polysynaptic excitatory pathways [PDF]

, 1989
The present study examined the role of N-methyl-D-aspartic acid (NMDA) receptors in synaptic plasticity in regular-spiking cells of rat frontal cortex. Intracortical stimulation, at levels subthreshold for elicitation of action potentials, evoked a late ...
Hablitz, John H., Sutor, Bernd
core   +1 more source

Potentiation Decay of Synapses and the Length Distributions of Synfire Chains Self-organized in Recurrent Neural Networks

, 2013
Synfire chains are thought to underlie precisely-timed sequences of spikes observed in various brain regions and across species. How they are formed is not understood. Here we analyze self-organization of synfire chains through the spike-timing dependent
Jin, Dezhe Z., Miller, Aaron
core   +1 more source

Chronic administration of atypical antipsychotics improves behavioral and synaptic defects of STOP null mice. [PDF]

, 2009
International audienceINTRODUCTION: Recent studies have suggested that schizophrenia is associated with alterations in the synaptic connectivity involving cytoskeletal proteins.
Annie Andrieux, Annie Schweitzer, Corinne Roucard, David Delotterie, Geoffrey Ruiz, Hôpital Le, Jacques Brocard, Karine Bress, Oise Suaud-chagny, Yann Roche   +9 more
core   +5 more sources

Locus Coeruleus Optogenetic Light Activation Induces Long-Term Potentiation of Perforant Path Population Spike Amplitude in Rat Dentate Gyrus

Frontiers in Systems Neuroscience, 2019
Norepinephrine (NE) in dentate gyrus (DG) produces NE-dependent long-term potentiation (NE-LTP) of the perforant path-evoked potential population spike both in vitro and in vivo. Chemical activators infused near locus coeruleus (LC), the source of DG NE,
Meghan A. L. Quinlan, Vanessa M. Strong, Darlene M. Skinner, Gerard M. Martin, Carolyn W. Harley, Susan G. Walling   +5 more
doaj   +1 more source

Short-Term Plasticity and Long-Term Potentiation in Magnetic Tunnel Junctions: Towards Volatile Synapses

, 2016
Synaptic memory is considered to be the main element responsible for learning and cognition in humans. Although traditionally non-volatile long-term plasticity changes have been implemented in nanoelectronic synapses for neuromorphic applications, recent
Roy, Kaushik, Sengupta, Abhronil
core   +1 more source