Managing Drug–Drug Interactions Involving the Non‐Prescription Opioid Loperamide Through Physiologically Based Pharmacokinetic Modeling [PDF]
CPT: Pharmacometrics & Systems PharmacologyLoperamide is a widely used nonprescription peripherally acting opioid indicated for diarrhea. Loperamide undergoes extensive first‐pass metabolism, primarily by cytochrome (CYP) 3A and CYP2C8, with minor contributions from CYP2B6 and CYP2D6, and ...
Zhu Zhou +6 more
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Loperamide poisoning resulting in death: a case report and literature review [PDF]
Frontiers in PharmacologyLoperamide is a medication commonly used to treat acute and chronic diarrhea and is generally considered safe because it poorly crosses the blood-brain barrier at therapeutic doses. However, in recent years, with the abuse and overdose of loperamide, its
Bowen Wang +5 more
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Journal of Pharmacopuncture, 2009 Objectives : The purpose of this study was to compare the effect of acpuncture and electro-acupuncture of low(EA(L)) and high(EA(H)) frequency at Haegye(ST41) on intestinal hypomotility induced with loperamide in rats.
Lee Sang-mi, Lee Hyun
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Loperamide increases mouse gut transit time in a dose-dependent manner with treatment duration-dependent effects on distinct gut microbial taxa [PDF]
Gut MicrobiomeIntestinal transit time has been recognized as an important factor in shaping the gut microbiota, although causality remains to be firmly demonstrated. The aim of this study was to evaluate the effect of different loperamide doses on the mouse intestinal
Anna Pii Hjørne +3 more
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Topical Loperamide-Encapsulated Liposomal Gel Increases the Severity of Inflammation and Accelerates Disease Progression in the Adjuvant-Induced Model of Experimental Rheumatoid Arthritis [PDF]
Frontiers in Pharmacology, 2017 This study evaluates the prophylactic effect of the peripherally-selective mu-opioid receptor agonist, loperamide, administered topically in a liposomal gel formulation on pain, inflammation, and disease progression in the adjuvant-induced model of ...
Susan Hua +4 more
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Racecadotril Versus Loperamide for Acute Diarrhea of Infectious Origin in Adults: A Systematic Review and Meta‐Analysis [PDF]
Health Science ReportsBackground and Aims Loperamide and racecadotril are two antidiarrheal medications with different mechanisms of action that are highly important for the treatment of diarrhea as a result of infectious pathology.
Maryam Aziz +12 more
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Sustainable Utilization of Agricultural By-Products: in vivo investigation of the antidiarrheal potential of Litchi chinensis seed extract [PDF]
Journal of PharmacopunctureObjectives: Diarrheal diseases remain a significant global health concern, with rising resistance to traditional pharmaceutical treatments. Litchi chinensis, a tropical fruit, is known for its medicinal properties, but its seed, which is often discarded ...
Mustakin Ahmed Shohel +8 more
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Evaluation of the pharmacokinetic interactions of montmorillonite powder or loperamide on pyrotinib in healthy volunteers [PDF]
Frontiers in PharmacologyAimsTo investigate the potential pharmacokinetic interactions of montmorillonite powder or loperamide on pyrotinib.MethodsThis study was a single-center, open-label, single-dose, fixed-sequence clinical trial conducted with healthy volunteers.
Yike Wang +14 more
doaj +2 more sources
Cancer Treatment and Research Communications, 2020 Background: Gefitinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) approved for first-line treatment of non-small cell lung cancer (NSCLC) with sensitizing EGFR mutations.
Christy W.S. Tong +4 more
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Differences in the Effectiveness of Uridine and Liriope platyphylla L. Between Complement Component 3 Deficiency- and Loperamide-Induced Constipation May Be Associated with the Alternative Regulation of the Cyclic Adenosine Monophosphate Downstream Signaling Pathway [PDF]
PharmaceuticalsBackground/Objectives: Constipation can be induced in animal models through various factors such as loperamide (Lop) or complement component 3 (C3) deficiency.
Hee Jin Song +11 more
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