Results 1 to 10 of about 21,270 (231)

Managing Drug–Drug Interactions Involving the Non‐Prescription Opioid Loperamide Through Physiologically Based Pharmacokinetic Modeling [PDF]

CPT: Pharmacometrics & Systems Pharmacology
Loperamide is a widely used nonprescription peripherally acting opioid indicated for diarrhea. Loperamide undergoes extensive first‐pass metabolism, primarily by cytochrome (CYP) 3A and CYP2C8, with minor contributions from CYP2B6 and CYP2D6, and ...
Zhu Zhou, Garrett R. Ainslie, Mengyao Li, Jean Dinh, Maciej J. Zamek‐Gliszczynski, Ping Zhao, Mary F. Paine   +6 more
doaj   +2 more sources

Anti-diarrheal drug loperamide induces dysbiosis in zebrafish microbiota via bacterial inhibition

Microbiome, 2023
Background Perturbations of animal-associated microbiomes from chemical stress can affect host physiology and health. While dysbiosis induced by antibiotic treatments and disease is well known, chemical, nonantibiotic drugs have recently been shown to ...
Rebecca J. Stevick, Bianca Audrain, Sébastien Bedu, Nicolas Dray, Jean-Marc Ghigo, David Pérez-Pascual   +5 more
doaj   +2 more sources

Case Report: Opioid Use Disorder Associated With Low/Moderate Dose of Loperamide in an Intellectual Disability Patient With CYP3A and P-Glycoprotein Reduced Activity

Frontiers in Psychiatry, 2022
Loperamide is an over-the-counter antidiarrheal for which increasing cases of abuse or misuse are described. We report the onset of opioid use disorder associated with low to moderate doses of loperamide in an intellectual disability patient without ...
Vincent Guinchat, Nicolas Ansermot, Kuntheavy Ing Lorenzini, Dimitri Politis, Youssef Daali, Chin B. Eap, Chin B. Eap, Chin B. Eap, Chin B. Eap, Séverine Crettol   +9 more
doaj   +2 more sources

Loperamide poisoning resulting in death: a case report and literature review [PDF]

Frontiers in Pharmacology
Loperamide is a medication commonly used to treat acute and chronic diarrhea and is generally considered safe because it poorly crosses the blood-brain barrier at therapeutic doses. However, in recent years, with the abuse and overdose of loperamide, its
Bowen Wang, Zhan Zhang, Ke Chen, Zhongyang Du, Tianchen Zhang, Ping Xie   +5 more
doaj   +2 more sources

Novel insights into mechanisms of inhibition of colonic motility by loperamide

Frontiers in Neuroscience
BackgroundIt is well known that opiates slow gastrointestinal (GI) transit, via suppression of enteric cholinergic neurotransmission throughout the GI tract, particularly the large intestine where constipation is commonly induced. It is not clear whether
Nabil Parkar, Nabil Parkar, Nabil Parkar, Nick J. Spencer, Luke Wiklendt, Trent Olson, Wayne Young, Wayne Young, Patrick Janssen, Warren C. McNabb, Julie E. Dalziel, Julie E. Dalziel   +11 more
doaj   +2 more sources

Loperamide increases mouse gut transit time in a dose-dependent manner with treatment duration-dependent effects on distinct gut microbial taxa [PDF]

Gut Microbiome
Intestinal transit time has been recognized as an important factor in shaping the gut microbiota, although causality remains to be firmly demonstrated. The aim of this study was to evaluate the effect of different loperamide doses on the mouse intestinal
Anna Pii Hjørne, Martin Steen Mortensen, Tine Rask Licht, Martin Frederik Laursen   +3 more
doaj   +2 more sources

Racecadotril Versus Loperamide for Acute Diarrhea of Infectious Origin in Adults: A Systematic Review and Meta‐Analysis [PDF]

Health Science Reports
Background and Aims Loperamide and racecadotril are two antidiarrheal medications with different mechanisms of action that are highly important for the treatment of diarrhea as a result of infectious pathology.
Maryam Aziz, Laiba Urooj Malik, Erum Javed, Syeda Zuha Sami, Muhammad Maaz, Muhammad Arham Khan, Muhammad Farmaan, Omer Farooq, Umer Iqbal, Aashish Kumar, Syed Ali Arsal, Shafin Bin Amin, Inibehe Ime Okon   +12 more
doaj   +2 more sources

Evaluation of the pharmacokinetic interactions of montmorillonite powder or loperamide on pyrotinib in healthy volunteers [PDF]

Frontiers in Pharmacology
AimsTo investigate the potential pharmacokinetic interactions of montmorillonite powder or loperamide on pyrotinib.MethodsThis study was a single-center, open-label, single-dose, fixed-sequence clinical trial conducted with healthy volunteers.
Yike Wang, Dai Li, Dai Li, Tong Zhang, Sumei Xu, Sumei Xu, Yanxin Zhang, Yanxin Zhang, Kaijing Zhao, Shaorong Li, Kai Shen, Xiaomin Li, Xiaomin Li, Pingsheng Xu, Pingsheng Xu   +14 more
doaj   +2 more sources

Loperamide Inhibits Replication of Severe Fever with Thrombocytopenia Syndrome Virus

Viruses, 2021
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by the SFTS virus (SFTSV). SFTS is mainly prevalent in East Asia.
Shuzo Urata, Jiro Yasuda, Masaharu Iwasaki   +2 more
doaj   +1 more source

Multi-strain probiotics alleviate loperamide-induced constipation by adjusting the microbiome, serotonin, and short-chain fatty acids in rats

Frontiers in Microbiology, 2023
Constipation is one of the most common gastrointestinal (GI) disorders worldwide. The use of probiotics to improve constipation is well known. In this study, the effect on loperamide-induced constipation by intragastric administration of probiotics ...
J. Jeong, Raja Ganesan, Yoo-Jeong Jin, H. Park, B. Min, M. Jeong, S. Yoon, M. Choi, Jieun Choi, J. Moon, Uigi Min, J. Lim, Do Yup Lee, Sang Hak Han, Y. Ham, B. Kim, K. Suk   +16 more
semanticscholar   +1 more source