Results 1 to 10 of about 17,797 (277)

Loperamide poisoning resulting in death: a case report and literature review [PDF]

Frontiers in Pharmacology
Loperamide is a medication commonly used to treat acute and chronic diarrhea and is generally considered safe because it poorly crosses the blood-brain barrier at therapeutic doses. However, in recent years, with the abuse and overdose of loperamide, its
Bowen Wang, Zhan Zhang, Ke Chen, Zhongyang Du, Tianchen Zhang, Ping Xie   +5 more
doaj   +2 more sources

Loperamide Induced Life Threatening Ventricular Arrhythmia [PDF]

Case Reports in Cardiology, 2016
Loperamide is over-the-counter antidiarrheal agent acting on peripherally located μ opioid receptors. It is gaining popularity among drug abusers as opioid substitute. We report a case of a 46-year-old male that was presented after cardiac arrest.
Ankit Upadhyay, Vijaykumar Bodar, Mohammad Malekzadegan, Sharanjit Singh, William Frumkin, Aditya Mangla, Kaushik Doshi   +6 more
doaj   +2 more sources

Loperamide Inhibits Tachykinin NK3-Receptor-Triggered Serotonin Release Without Affecting NK2-Receptor-Triggered Serotonin Release From Guinea Pig Colonic Mucosa

Journal of Pharmacological Sciences, 2005
The effect of loperamide on tachykinin NK2- and NK3-receptor-mediated 5-HT outflow from guinea pig colonic mucosa was investigated in vitro. The selective tachykinin NK2-receptor agonist [β-Ala8]-neurokinin A4–10 (βAla-NKA) or the selective NK3-receptor ...
Shu-ichi Kojima, Masashi Ikeda, Yuichiro Kamikawa   +2 more
doaj   +3 more sources

Loperamide increases mouse gut transit time in a dose-dependent manner with treatment duration-dependent effects on distinct gut microbial taxa [PDF]

Gut Microbiome
Intestinal transit time has been recognized as an important factor in shaping the gut microbiota, although causality remains to be firmly demonstrated. The aim of this study was to evaluate the effect of different loperamide doses on the mouse intestinal
Anna Pii Hjørne, Martin Steen Mortensen, Tine Rask Licht, Martin Frederik Laursen   +3 more
doaj   +2 more sources

Ventricular fibrillation due to overdose of loperamide, the “poor man’s methadone” [PDF]

Journal of Community Hospital Internal Medicine Perspectives, 2017
Loperamide is an over-the-counter antidiarrheal agent that is considered by many patients to be safe, but has been used as a drug of abuse due to its opioid properties.
Amr Salama, Yana Levin, Pramod Jha, Richard Alweis   +3 more
doaj   +2 more sources

Sustainable Utilization of Agricultural By-Products: in vivo investigation of the antidiarrheal potential of Litchi chinensis seed extract [PDF]

Journal of Pharmacopuncture
Objectives: Diarrheal diseases remain a significant global health concern, with rising resistance to traditional pharmaceutical treatments. Litchi chinensis, a tropical fruit, is known for its medicinal properties, but its seed, which is often discarded ...
Mustakin Ahmed Shohel, Md. Humayan Kabir, Ivvala Anand Shaker, Sumaiya Siddika, Sheikh Arafat Rahman, Sumaiya Siddiquea, Nirmal Chandra Mahat, Tarique Muhammad Tawabul Islam, Md. Abul Kashem Tang   +8 more
doaj   +2 more sources

Racecadotril Versus Loperamide for Acute Diarrhea of Infectious Origin in Adults: A Systematic Review and Meta‐Analysis [PDF]

Health Science Reports
Background and Aims Loperamide and racecadotril are two antidiarrheal medications with different mechanisms of action that are highly important for the treatment of diarrhea as a result of infectious pathology.
Maryam Aziz, Laiba Urooj Malik, Erum Javed, Syeda Zuha Sami, Muhammad Maaz, Muhammad Arham Khan, Muhammad Farmaan, Omer Farooq, Umer Iqbal, Aashish Kumar, Syed Ali Arsal, Shafin Bin Amin, Inibehe Ime Okon   +12 more
doaj   +2 more sources

Evaluation of the Effect of Loperamide on the Cardiac Repolarization Interval Using Exposure–Response Analysis [PDF]

Clinical and Translational Science
This analysis assessed the relationship between the plasma concentrations of loperamide and its N‐desmethyl loperamide meta‐ bolite (M1) and the potential QT interval prolongation at therapeutic and supratherapeutic doses.
Belén Valenzuela, Per Olsson Gisleskog, Iolanda Cirillo, Erwin Coenen, Jay Ariyawansa, Saberi Rana Ali, Samiha Takhtoukh, Juan José Pérez‐Ruixo, Oliver Ackaert   +8 more
doaj   +2 more sources

Evaluation of the pharmacokinetic interactions of montmorillonite powder or loperamide on pyrotinib in healthy volunteers [PDF]

Frontiers in Pharmacology
AimsTo investigate the potential pharmacokinetic interactions of montmorillonite powder or loperamide on pyrotinib.MethodsThis study was a single-center, open-label, single-dose, fixed-sequence clinical trial conducted with healthy volunteers.
Yike Wang, Dai Li, Dai Li, Tong Zhang, Sumei Xu, Sumei Xu, Yanxin Zhang, Yanxin Zhang, Kaijing Zhao, Shaorong Li, Kai Shen, Xiaomin Li, Xiaomin Li, Pingsheng Xu, Pingsheng Xu   +14 more
doaj   +2 more sources

Differences in the Effectiveness of Uridine and Liriope platyphylla L. Between Complement Component 3 Deficiency- and Loperamide-Induced Constipation May Be Associated with the Alternative Regulation of the Cyclic Adenosine Monophosphate Downstream Signaling Pathway [PDF]

Pharmaceuticals
Background/Objectives: Constipation can be induced in animal models through various factors such as loperamide (Lop) or complement component 3 (C3) deficiency.
Hee Jin Song, Eun Seo Park, Ji Eun Kim, Ayun Seol, Su Jeong Lim, Su Ha Wang, Ye Ryeong Kim, Ye Eun Ryu, So Hae Park, Jumin Park, Hyun Gu Kang, Dae Youn Hwang   +11 more
doaj   +2 more sources