Results 11 to 20 of about 23,058 (301)

Coadministration of Lactulose with Probiotics Ameliorates Loperamide-Induced Constipation in Mice

open access: hybridPreventive Nutrition and Food Science, 2023
We evaluated the efficacy of mixtures of lactulose with probiotic strains to ameliorate constipation and to identify suitable probiotic strains. Constipation was induced in Institute of Cancer Research mice (6-week-old, male) by the administering ...
C. Park   +5 more
semanticscholar   +3 more sources

Hemp seeds attenuate loperamide-induced constipation in mice [PDF]

open access: goldFrontiers in Microbiology
Constipation is a common gastrointestinal disease that seriously affects human physical and mental health. Studies have reported that hemp seeds can improve constipation, however the specific mechanism is still unclear.
H. Hua   +7 more
semanticscholar   +2 more sources

Loperamide: an emerging drug of abuse and cause of prolonged QTc. [PDF]

open access: diamondClinical medicine (London), 2021
Loperamide is an over-the-counter medication which is commonly used to treat diarrhoea. In excessive doses, loperamide acts as an opioid on the central nervous system, which contributes to its increasing popularity as an alternative substance for opiate ...
George Whittaker, Joseph W. Newman
semanticscholar   +2 more sources

The Effect of Acupuncture and Electro-acupuncture at ST41 on Intestinal Hypomotility Induced with Loperamide in Rats

open access: hybridJournal of Pharmacopuncture, 2009
Objectives : The purpose of this study was to compare the effect of acpuncture and electro-acupuncture of low(EA(L)) and high(EA(H)) frequency at Haegye(ST41) on intestinal hypomotility induced with loperamide in rats.
Lee Sang-mi, Lee Hyun
doaj   +2 more sources

Gut microbiota is involved in the alleviation of loperamide‐induced constipation by honey supplementation in mice [PDF]

open access: hybridFood Science & Nutrition, 2020
Constipation is one of the most common functional gastrointestinal disorders accompanied with intestinal dysbiosis. Laxatives for constipation usually have side effects.
Yuyuan Li   +8 more
semanticscholar   +2 more sources

Topical Loperamide-Encapsulated Liposomal Gel Increases the Severity of Inflammation and Accelerates Disease Progression in the Adjuvant-Induced Model of Experimental Rheumatoid Arthritis [PDF]

open access: goldFrontiers in Pharmacology, 2017
This study evaluates the prophylactic effect of the peripherally-selective mu-opioid receptor agonist, loperamide, administered topically in a liposomal gel formulation on pain, inflammation, and disease progression in the adjuvant-induced model of ...
Susan Hua   +4 more
doaj   +2 more sources

Repurposing loperamide to overcome gefitinib resistance by triggering apoptosis independent of autophagy induction in KRAS mutant NSCLC cells

open access: goldCancer Treatment and Research Communications, 2020
Background: Gefitinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) approved for first-line treatment of non-small cell lung cancer (NSCLC) with sensitizing EGFR mutations.
Christy W.S. Tong   +4 more
doaj   +2 more sources

The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose

open access: yesBiomolecules, 2023
Loperamide has been a safe and effective treatment for diarrhea for many years. However, many cases of cardiotoxicity with intentional abuse of loperamide ingestion have recently been reported.
Hua Rong Lu   +7 more
doaj   +1 more source

Loperamide Overdose [PDF]

open access: yesCureus, 2019
In light of the opioid epidemic, cardiac complications following a loperamide overdose are a growing concern for patients presenting to the emergency department (ED). Here, we present the case of a 35-year-old male with long QT syndrome who presented following a loperamide overdose and was receiving multiple shocksĀ because of the resulting arrhythmias ...
Arnold, Casey   +1 more
openaire   +2 more sources

Polysaccharides from Holothuria leucospilota Relieve Loperamide-Induced Constipation Symptoms in Mice

open access: yesInternational Journal of Molecular Sciences, 2023
A vital bioactive component of marine resources is Holothuria leucospilota polysaccharides (HLP). This study examined whether HLP could regulate intestinal flora to treat loperamide-induced constipation.
Ziqi Wang   +9 more
semanticscholar   +1 more source

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