Results 11 to 20 of about 22,601 (285)
Anti-diarrheal drug loperamide induces dysbiosis in zebrafish microbiota via bacterial inhibition
Microbiome, 2023 Background Perturbations of animal-associated microbiomes from chemical stress can affect host physiology and health. While dysbiosis induced by antibiotic treatments and disease is well known, chemical, nonantibiotic drugs have recently been shown to ...
Rebecca J. Stevick +5 more
doaj +2 more sources
Frontiers in Psychiatry, 2022 Loperamide is an over-the-counter antidiarrheal for which increasing cases of abuse or misuse are described. We report the onset of opioid use disorder associated with low to moderate doses of loperamide in an intellectual disability patient without ...
Vincent Guinchat +9 more
doaj +2 more sources
Loperamide Inhibits Replication of Severe Fever with Thrombocytopenia Syndrome Virus
Viruses, 2021 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by the SFTS virus (SFTSV). SFTS is mainly prevalent in East Asia.
Shuzo Urata +2 more
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Novel insights into mechanisms of inhibition of colonic motility by loperamide
Frontiers in NeuroscienceBackgroundIt is well known that opiates slow gastrointestinal (GI) transit, via suppression of enteric cholinergic neurotransmission throughout the GI tract, particularly the large intestine where constipation is commonly induced. It is not clear whether
Nabil Parkar +11 more
doaj +2 more sources
Risk of Cardiac Lesion with Chronic and Acute Use of Loperamide—An Integrative Review
Journal of Cardiovascular Development and Disease, 2022 Loperamide is a synthetic opioid commonly used as an antidiarrheal due to its activation of u-opioid receptors in the myenteric plexus. In therapeutic doses, it inhibits peristalsis and has anti-secretory and anti-motility effects, until metabolized by ...
Bruna Cremonezi Lammoglia +9 more
doaj +2 more sources
Hemp seeds attenuate loperamide-induced constipation in mice [PDF]
Frontiers in MicrobiologyConstipation is a common gastrointestinal disease that seriously affects human physical and mental health. Studies have reported that hemp seeds can improve constipation, however the specific mechanism is still unclear.
Hua Huang +7 more
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Coadministration of Lactulose with Probiotics Ameliorates Loperamide-Induced Constipation in Mice
Preventive Nutrition and Food Science, 2023 We evaluated the efficacy of mixtures of lactulose with probiotic strains to ameliorate constipation and to identify suitable probiotic strains. Constipation was induced in Institute of Cancer Research mice (6-week-old, male) by the administering ...
Chun Woong Park +5 more
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Loperamide: an emerging drug of abuse and cause of prolonged QTc [PDF]
Clinical medicine (London), 2021 Loperamide is an over-the-counter medication which is commonly used to treat diarrhoea. In excessive doses, loperamide acts as an opioid on the central nervous system, which contributes to its increasing popularity as an alternative substance for opiate ...
George Whittaker, Joseph Newman
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Gut microbiota is involved in the alleviation of loperamide‐induced constipation by honey supplementation in mice [PDF]
Food Science & Nutrition, 2020 Constipation is one of the most common functional gastrointestinal disorders accompanied with intestinal dysbiosis. Laxatives for constipation usually have side effects.
Yuyuan Li +8 more
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