Results 11 to 20 of about 22 (22)
Neurogastroenterology &Motility, EarlyView.Alterations in whole gut transit time (WGTT) significantly impact microbiome composition and bile acid metabolism. Using senna and loperamide, we show that WGTT changes influence bacterial diversity, bile acid profiles, and fibroblast growth factor 19, with effects reversing after 16 days—highlighting the dynamic gut‐microbiome‐bile acid interplay ...
Evette B. M. Hillman +11 more
wiley +1 more source
Light‐Activated Pharmacological Tools for Exploring the Cholinergic System
Medicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni +5 more
wiley +1 more source
Cancer Innovation, Volume 4, Issue 3, June 2025.ABSTRACT Background The phosphoinositide 3‐kinase (PI3K)/protein kinase B (PKB or AKT)/mammalian target of rapamycin (mTOR) signaling pathway (PAM pathway) plays a critical role in breast cancer pathogenesis and progression, and is closely linked with resistance to endocrine therapy in advanced breast cancer.
The Breast Cancer Expert Committee of the National Quality Control Center for Cancer +3 more
wiley +1 more source
iMeta, Volume 4, Issue 3, June 2025.Using metagenomic sequencing and bioinformatics analysis of fecal samples from rectal cancer patients and corresponding mouse models, our study identifies a strong association between Lactobacillus abundance and acute chemoradiotherapy‐induced intestinal injury (ACRIII). Elevated Lactobacillus levels before treatment were consistently linked to reduced
Lu Yu +16 more
wiley +1 more source
Stool Microbiome Features and Weight Change Response to Treatment for cancer cachexia
Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.ABSTRACT Background and Aims Cancer cachexia is characterised by significant weight loss and muscle wasting that adversely affects patient outcomes. Nutritional interventions in cancer cachexia leads to improved outcomes, including improved weight change. However, there are wide variations in weight response to dietary interventions.
Rima Nasrah +5 more
wiley +1 more source
Nanomedicine Approaches for Autophagy Modulation in Cancer Therapy
Small Science, Volume 5, Issue 6, June 2025.Autophagy modulation holds promise for enhancing cancer treatment, yet clinical translation remains challenging. This review explores nanomedicine‐based strategies to improve autophagy‐targeting drugs, highlighting their synergy with chemotherapy, immunotherapy, phototherapy, and gene therapy. It also discusses nanoparticle design and clinical progress,
Sohaib Mahri +11 more
wiley +1 more source
The Journal of Dermatology, Volume 52, Issue 6, Page 1059-1065, June 2025.ABSTRACT Apremilast is a phosphodiesterase 4 inhibitor approved for moderate to severe psoriasis in Japan. Apremilast significantly improved Physician's Global Assessment (PGA) and Dermatology Life Quality Index (DLQI) both at 6 and 12 months in a previously published primary post‐surveillance study.
Mamitaro Ohtsuki +8 more
wiley +1 more source
CDK4/6 inhibitor in combination with aromatase inhibitor effective in metastatic hidradenocarcinoma
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Valerie Glatzel +6 more
wiley +1 more source
British Journal of Clinical Pharmacology, Volume 91, Issue 6, Page 1802-1820, June 2025.Abstract Aim The aim of this study was to investigate the impact of pharmacist‐led person‐centred medicines reviews in general practices on medicines appropriateness, polypharmacy indicators (high‐risk prescribing markers), and patient‐reported outcome measures (PROMs).
Clare Kinahan +9 more
wiley +1 more source
Trends in tricyclic antidepressant prescribing and poisoning in England and Wales 2016–2020
British Journal of Clinical Pharmacology, Volume 91, Issue 6, Page 1727-1738, June 2025.Abstract Aims Tricyclic antidepressants (TCAs) are commonly prescribed despite no longer being a NICE‐recommended first‐line treatment for depression and their recognized toxicity in overdose. This study examined prescribing, mortality, hospital admissions and clinical TCA data to quantify the use and impact of TCAs in England and Wales.
Laurence Gray +10 more
wiley +1 more source