Results 21 to 30 of about 22,601 (285)

Improvement of loperamide-hydrochloride-induced intestinal motility disturbance by Platycodon grandiflorum polysaccharides through effects on gut microbes and colonic serotonin

Frontiers in Cellular and Infection Microbiology, 2023
Constipation is a common gastrointestinal symptom characterized by intestinal motility disorder. The effects of Platycodon grandiflorum polysaccharides (PGP) on intestinal motility have not been confirmed.
Mengqi Hao, Jing Song, Xiaohu Zhai, Nuo Cheng, Cong Xu, Shuangying Gui, Juan Chen   +6 more
semanticscholar   +1 more source

The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose

Biomolecules, 2023
Loperamide has been a safe and effective treatment for diarrhea for many years. However, many cases of cardiotoxicity with intentional abuse of loperamide ingestion have recently been reported.
Hua Rong Lu, Bruce P. Damiano, Mohamed Kreir, Jutta Rohrbacher, Henk van der Linde, Tamerlan Saidov, Ard Teisman, David J. Gallacher   +7 more
doaj   +1 more source

Multi-strain probiotics alleviate loperamide-induced constipation by adjusting the microbiome, serotonin, and short-chain fatty acids in rats

Frontiers in Microbiology, 2023
Constipation is one of the most common gastrointestinal (GI) disorders worldwide. The use of probiotics to improve constipation is well known. In this study, the effect on loperamide-induced constipation by intragastric administration of probiotics ...
J. Jeong, Raja Ganesan, Yoo-Jeong Jin, H. Park, B. Min, M. Jeong, S. Yoon, M. Choi, Jieun Choi, J. Moon, Uigi Min, J. Lim, Do Yup Lee, Sang Hak Han, Y. Ham, B. Kim, K. Suk   +16 more
semanticscholar   +1 more source

Polysaccharides from Holothuria leucospilota Relieve Loperamide-Induced Constipation Symptoms in Mice

International Journal of Molecular Sciences, 2023
A vital bioactive component of marine resources is Holothuria leucospilota polysaccharides (HLP). This study examined whether HLP could regulate intestinal flora to treat loperamide-induced constipation.
Ziqi Wang, Yali Shi, Shiyu Zeng, Y. Zheng, Huaijie Wang, H. Liao, Jie Song, Xinyue Zhang, Jun Cao, Chuan Li   +9 more
semanticscholar   +1 more source

Loperamide Overdose [PDF]

Cureus, 2019
In light of the opioid epidemic, cardiac complications following a loperamide overdose are a growing concern for patients presenting to the emergency department (ED). Here, we present the case of a 35-year-old male with long QT syndrome who presented following a loperamide overdose and was receiving multiple shocks because of the resulting arrhythmias ...
Arnold, Casey, Martinez Martinez, Carmen J   +1 more
openaire   +2 more sources

Luteolin ameliorates loperamide-induced functional constipation in mice

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2023
Functional constipation (FC) is one of the most common gastrointestinal disorders characterized by hard stools and infrequent bowel movements, which is associated with dysfunction of the enteric nervous system and intestinal motility.
Yu-Jue Wang, Hua Jiang, Lijun Wang, Huiping Gan, Xinchun Xiao, Liang Huang, Wenxin Li, Zongrun Li   +7 more
semanticscholar   +1 more source

A Heart-Wrenching Case of Loperamide Toxicity [PDF]

Asia Pacific Journal of Medical Toxicology, 2019
Background: Loperamide is an insoluble meperidine analog that is commonly used for diarrhea. It is an inexpensive and frequently available over the counter drug.
Sadaf Sheikh, Muhammad Akbar Baig
doaj   +1 more source

Rifaximin Ameliorates Loperamide-Induced Constipation in Rats through the Regulation of Gut Microbiota and Serum Metabolites

Nutrients, 2023
Structural changes in the gut microbiota are closely related to the development of functional constipation, and regulating the gut microbiota can improve constipation.
Mei-Ching Luo, Peiwei Xie, Xuehong Deng, Jiahui Fan, Lishou Xiong   +4 more
semanticscholar   +1 more source

Quantitative analysis of Loperamide hydrochloride in the presence its acid degradation products [PDF]

Hemijska Industrija, 2009
The aim of this work was to develop a new RP-HPLC method for the determination of loperamide hydrochloride in the presence of its acid degradation products.
Savić Ivana M., Nikolić Goran S., Savić Ivan M., Marinković Valentina D.   +3 more
doaj   +1 more source

Based on Network Pharmacology and Gut Microbiota Analysis to Investigate the Mechanism of the Laxative Effect of Pterostilbene on Loperamide-Induced Slow Transit Constipation in Mice

Frontiers in Pharmacology, 2022
Background: Pterostilbene (PTE) is a natural polyphenol compound that has been proven to improve intestinal inflammation, but its laxative effect on slow transit constipation (STC) has never been studied.
Zhiwei Yao, Siqi Fu, Bingbing Ren, Lushun Ma, Daqing Sun   +4 more
semanticscholar   +1 more source