Frontiers in Psychiatry, 2022 Loperamide is an over-the-counter antidiarrheal for which increasing cases of abuse or misuse are described. We report the onset of opioid use disorder associated with low to moderate doses of loperamide in an intellectual disability patient without ...
Vincent Guinchat +9 more
doaj +1 more source
Changing Gastrointestinal Transit Time Alters Microbiome Composition and Bile Acid Metabolism: A Cross-Over Study in Healthy Volunteers. [PDF]
Neurogastroenterol MotilAlterations in whole gut transit time (WGTT) significantly impact microbiome composition and bile acid metabolism. Using senna and loperamide, we show that WGTT changes influence bacterial diversity, bile acid profiles, and fibroblast growth factor 19, with effects reversing after 16 days—highlighting the dynamic gut‐microbiome‐bile acid interplay ...
Hillman EBM +11 more
europepmc +2 more sources
Local loperamide injection reduces mechanosensitivity of rat cutaneous, nociceptive C-fibers. [PDF]
PLoS ONE, 2012 Loperamide reverses signs of mechanical hypersensitivity in an animal model of neuropathic pain suggesting that peripheral opioid receptors may be suitable targets for the treatment of neuropathic pain.
Matthias Ringkamp +8 more
doaj +1 more source
Loperamide abuse and cardiotoxicity [PDF]
Journal of Community Hospital Internal Medicine Perspectives, 2017 To the Editor:With increasing restrictions and safety protocols implemented in prescribing opioids, there has been an increased incidence of recreational abuse of over-the-counter medications, incl...
Jefferson Chambers +2 more
openaire +4 more sources
Is there such a thing as a 'lope' dope? Analysis of loperamide-related European Medicines Agency (EMA) pharmacovigilance database reports. [PDF]
PLoS ONE, 2018 BACKGROUND:Among over-the-counter (OTC) drugs, loperamide has recently emerged for its potential of misuse and cardiotoxicity issues. Hence, we aimed here at assessing the loperamide-related cases being reported to the EMA's EudraVigilance (EV) database.
Fabrizio Schifano, Stefania Chiappini
doaj +1 more source
Case Reports in Oncology, 2021 Irinotecan hydrochloride (irinotecan) is a chemotherapeutic agent used in the treatment of solid tumors. In addition to severe neutropenia and delayed diarrhea, irinotecan causes cholinergic syndrome, characterized by abdominal pain and acute diarrhea ...
Kazuki Uchiyama +4 more
doaj +1 more source
Effects of Loperamide on Mechanical Allodynia Induced by Herpes Simplex Virus Type-1 in Mice
Journal of Pharmacological Sciences, 2007 In the present study, we investigated whether the peripherally acting µ-opioid receptor agonist loperamide would inhibit allodynia in the non-inflamed dermatome of mice with herpetic pain.
Atsushi Sasaki +5 more
doaj +1 more source
Increased systemic availability of loperamide after oral administration of loperamide and loperamide oxide with cotrimoxazole [PDF]
British Journal of Clinical Pharmacology, 1996 1 The effects of concurrent administration of cotrimoxazole on the plasma concentration‐time profiles of loperamide and its oxide were investigated in two separate studies in healthy male volunteers. Cotrimoxazole (960 mg, twice daily) was administered for 24 h before and 48 h after an oral dose of loperamide oxide (4 mg) or loperamide (4 mg).2 ...
Farhad Kamali, M. L. Huang
openaire +3 more sources
Effects of loperamide on the human hypothalamo-pituitary-adrenal axis in vivo and in vitro. [PDF]
, 1992 Loperamide, an opiate agonist of high specificity for p-receptors, was recently reported to suppress ACTH and cortisol levels in normal subjects, but not in patients with proven ACTH-dependent Cushing’s disease. However, there is little information on
Auernhammer, Christoph J. +4 more
core +1 more source
Travelers’ diarrhea and other gastrointestinal symptoms among Boston-area international travelers [PDF]
, 2017 INTRODUCTION: Travelers' diarrhea (TD) and non-TD gastrointestinal (GI) symptoms are common among international travelers. In a study of short-term travelers from Switzerland to developing countries, the most common symptom experienced was severe ...
Barnett, Elizabeth D. +8 more
core +1 more source