Anti-diarrheal drug loperamide induces dysbiosis in zebrafish microbiota via bacterial inhibition
Microbiome, 2023 Background Perturbations of animal-associated microbiomes from chemical stress can affect host physiology and health. While dysbiosis induced by antibiotic treatments and disease is well known, chemical, nonantibiotic drugs have recently been shown to ...
Rebecca J. Stevick +5 more
doaj +1 more source
Quantitative proteomic analysis reveals the effects of mu opioid agonists on HT22 cells
Frontiers in Pharmacology, 2023 Introduction: At present, the mu opioid receptor is the most important neuroaesthetics receptor in anesthesiology research, and the damage that it does to the nervous system is unknown.Methods: We investigated the effects of loperamide, an agonist of the
Xutong Zhang +4 more
doaj +1 more source
An opioid-like system regulating feeding behavior in C. elegans [PDF]
, 2015 Neuropeptides are essential for the regulation of appetite. Here we show that neuropeptides could regulate feeding in mutants that lack neurotransmission from the motor neurons that stimulate feeding muscles. We identified nlp-24 by an RNAi screen of 115
Artyukhin, Alexander B. +3 more
core +3 more sources
Dual effects of brain sparing opioid in newborn rats: Analgesia and hyperalgesia
Neurobiology of Pain, 2018 Effective pain management in neonates without the unwanted central nervous system (CNS) side effects remains an unmet need. To circumvent these central effects we tested the peripherally acting (brain sparing) opioid agonist loperamide in neonate rats ...
Gong Kerui, Luc Jasmin
doaj +1 more source
A life-threatening ventricular arrhythmia secondary to loperamide abuse, “a poor man’s methadone”
Heart Vessels and Transplantation, 2021 The case of a patient with repetitive syncope episodes with a history of using loperamide at high doses for recreational purposes in search of an effect similar to heroin, is reported.
Miguel A. Rojas Carrera +3 more
doaj +1 more source
Cytotoxic effects of opiate agonist loperamide hydrochloride on human oral cancer cells—an invitro study [PDF]
Exploration of MedicineAim: Loperamide hydrochloride (HCl), a peripheral opioid receptor agonist primarily used as an antidiarrheal drug, has been reported to induce apoptosis in various cancer cell lines.
Chie Ching Tan +5 more
doaj +1 more source
‘ Loperamide overdose induces ventricular tachycardia with catastrophic outcomes’
Journal of Community Hospital Internal Medicine Perspectives, 2020 Loperamide is a widely available, over-the-counter medication. The advent of the opioid epidemic has seen cases of loperamide overdose being reported. The common side effects of the medication can be relatively benign, but at high doses, loperamide can ...
Zain Ali +4 more
doaj +1 more source
Loperamide cases reported to United States poison centers, 2010–2022
Injury Epidemiology, 2023 Background Intentional use of high doses of loperamide has been linked to serious cardiac toxicity. The objective of this study is to investigate the characteristics and trends of loperamide cases reported to United States (US) poison centers and to ...
Aaditya Patel +7 more
doaj +1 more source
The Effectiveness of Yoga for Irritable Bowel Syndrome: A Systematic Review. [PDF]
Compr PhysiolEvidence from 10 studies suggests yoga improves IBS symptoms, stress/anxiety, and QOL; study quality was moderate, supporting the need for robust RCTs. IBS, irritable bowel syndrome; QOL, quality of life. ABSTRACT Background Irritable Bowel Syndrome (IBS) is a common functional gastrointestinal disorder affecting 5%–10% of the global population and is ...
Pavan F +5 more
europepmc +2 more sources
Recent Changes in Drug Abuse Scenario: The Novel Psychoactive Substances (NPS) Phenomenon [PDF]
, 2019 copyright 2019 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are ...
Catalani, Valeria +7 more
core +3 more sources