Results 31 to 40 of about 23,058 (301)

Prevention of Loperamide-Induced Constipation in Mice and Alteration of 5-Hydroxytryotamine Signaling by Ligilactobacillus salivarius Li01

Nutrients, 2022
Although Ligilactobacillus salivarius Li01 (Li01) has shown much promise in preventing multiple gastrointestinal diseases, the potential of the probiotic in alleviating constipation and the related mechanisms remain unclear. In this study, the effects of
Bo-Chen Qiu, Liancai Zhu, Shuobo Zhang, Shengyi Han, Yiqiu Fei, Furong Ba, Björn Berglund, Lanjuan Li, Mingfei Yao   +8 more
semanticscholar   +1 more source

Travelers’ diarrhea and other gastrointestinal symptoms among Boston-area international travelers [PDF]

, 2017
INTRODUCTION: Travelers' diarrhea (TD) and non-TD gastrointestinal (GI) symptoms are common among international travelers. In a study of short-term travelers from Switzerland to developing countries, the most common symptom experienced was severe ...
Barnett, Elizabeth D., Benoit, Christine M., Chen, Lin H., Hamer, Davidson H., Han, Pauline V., Jentes, Emily S., NacLeod, William B., Stoney, Rhett J., Wilson, Mary E.   +8 more
core   +1 more source

Loperamide-induced cardiogenic syncope: a case report of a life-threatening presentation of an over-the-counter drug

European Heart Journal: Case Reports, 2023
Background Loperamide at supratherapeutic doses can cause cardiac toxicity, presenting as cardiogenic shock, prolonged QT, malignant arrhythmias, or in severe cases sudden cardiac death. Surreptitious loperamide use is difficult to diagnose.
V. Hegde, Tarun Dalia, T. Tayeb, E. Cotter, A. Vidic   +4 more
semanticscholar   +1 more source

An opioid-like system regulating feeding behavior in C. elegans [PDF]

, 2015
Neuropeptides are essential for the regulation of appetite. Here we show that neuropeptides could regulate feeding in mutants that lack neurotransmission from the motor neurons that stimulate feeding muscles. We identified nlp-24 by an RNAi screen of 115
Artyukhin, Alexander B., Avery, Leon, Cheong, Mi Cheong, You, Yong-Jai   +3 more
core   +3 more sources

Cytotoxic effects of opiate agonist loperamide hydrochloride on human oral cancer cells—an invitro study [PDF]

Exploration of Medicine
Aim: Loperamide hydrochloride (HCl), a peripheral opioid receptor agonist primarily used as an antidiarrheal drug, has been reported to induce apoptosis in various cancer cell lines.
Chie Ching Tan, Ursula Siau Lan Ting, Zi Xian Khoo, Prashanti Chippagiri, Suan Phaik Khoo, Spoorthi Ravi Banavar   +5 more
doaj   +1 more source

Cymbopogon citratus (DC.) Stapf aqueous extract ameliorates loperamide-induced constipation in mice by promoting gastrointestinal motility and regulating the gut microbiota

Frontiers in Microbiology, 2022
Slow transit constipation (STC) is the most common type of functional constipation. Drugs with good effects and few side effects are urgently needed form the treatment of STC.
Xiaoyu Gao, Yifan Hu, Yafei Tao, Shuangfeng Liu, Haowen Chen, Jiayi Li, Yan Zhao, Jun Sheng, Yang Tian, Yuan-hong Fan   +9 more
semanticscholar   +1 more source

Bifidobacterium lactis TY-S01 Prevents Loperamide-Induced Constipation by Modulating Gut Microbiota and Its Metabolites in Mice

Frontiers in Nutrition, 2022
Probiotics have received widespread attention as a healthy ingredient. The preventive effect of Bifidobacterium lactis TY-S01 on loperamide-induced constipation in mice was investigated in this study.
Tian Tang, Jing Wang, Yuanyuan Jiang, Xu Zhu, Zhen Zhang, Yuying Wang, Xinyao Shu, Ya-ting Deng, Fengyi Zhang   +8 more
semanticscholar   +1 more source

Dual effects of brain sparing opioid in newborn rats: Analgesia and hyperalgesia

Neurobiology of Pain, 2018
Effective pain management in neonates without the unwanted central nervous system (CNS) side effects remains an unmet need. To circumvent these central effects we tested the peripherally acting (brain sparing) opioid agonist loperamide in neonate rats ...
Gong Kerui, Luc Jasmin
doaj   +1 more source

Loperamide cases reported to United States poison centers, 2010–2022

Injury Epidemiology, 2023
Background Intentional use of high doses of loperamide has been linked to serious cardiac toxicity. The objective of this study is to investigate the characteristics and trends of loperamide cases reported to United States (US) poison centers and to ...
Aaditya Patel, Natalie I. Rine, Henry A. Spiller, Hannah Hays, Jaahnavi Badeti, Motao Zhu, Kele Ding, Gary A. Smith   +7 more
doaj   +1 more source

Quantitative proteomic analysis reveals the effects of mu opioid agonists on HT22 cells

Frontiers in Pharmacology, 2023
Introduction: At present, the mu opioid receptor is the most important neuroaesthetics receptor in anesthesiology research, and the damage that it does to the nervous system is unknown.Methods: We investigated the effects of loperamide, an agonist of the
Xutong Zhang, Yani Lou, Dongxu Zheng, Jialin Lu, Dansi Qi   +4 more
doaj   +1 more source