Results 41 to 50 of about 23,058 (301)

Recent Changes in Drug Abuse Scenario: The Novel Psychoactive Substances (NPS) Phenomenon [PDF]

, 2019
copyright 2019 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are ...
Catalani, Valeria, Chilcott, Robert, Corazza, Ornella, Corkery, John, Guirguis, Amira, Marrinan, Shanna, Martinotti, Giovanni, Zloh, Mire   +7 more
core   +3 more sources

‘ Loperamide overdose induces ventricular tachycardia with catastrophic outcomes’

Journal of Community Hospital Internal Medicine Perspectives, 2020
Loperamide is a widely available, over-the-counter medication. The advent of the opioid epidemic has seen cases of loperamide overdose being reported. The common side effects of the medication can be relatively benign, but at high doses, loperamide can ...
Zain Ali, Umer Shoukat, Mariya Khan, Sohaib Roomi, Waqas Ullah   +4 more
doaj   +1 more source

A life-threatening ventricular arrhythmia secondary to loperamide abuse, “a poor man’s methadone”

Heart Vessels and Transplantation, 2021
The case of a patient with repetitive syncope episodes with a history of using loperamide at high doses for recreational purposes in search of an effect similar to heroin, is reported.
Miguel A. Rojas Carrera, Juan Guzman Olea, Gabriel Guzman Olea, Ernesto Hernandez Jimenez   +3 more
doaj   +1 more source

Efficacy of Bacillus coagulans BC01 on loperamide hydrochloride-induced constipation model in Kunming mice

Frontiers in Nutrition, 2022
In this study, the laxative effect of Bacillus coagulans BC01 (BC01) in mice was investigated using a functional constipation mouse model. Six-week-old male specific pathogen-free (SPF) Kunming mice were randomly divided into five groups: normal control ...
Xu Zhou, Yafang Chen, Xinying Ma, Yang Yu, Xueping Yu, Xiaoyong Chen, Huayi Suo   +6 more
semanticscholar   +1 more source

Racecadotril for acute diarrhoea in children: systematic review and meta-analyses [PDF]

, 2015
OBJECTIVE Racecadotril is an antisecretory agent that can prevent fluid/electrolyte depletion from the bowel as a result of acute diarrhoea, without affecting intestinal motility. An up-to-date systematic review is indicated to summarise the evidence on
Alam, Alvarez Calatayud, Anthony Akobeng, Bruzzese, Cojocaru, Cézard, Eberlin, Freedman, Gill, Guarino, Gutierrez Castrellon, Higgins, Higgins, Huighebaert, Lehert, Mehta, Melendez Garcia, Morris Gordon, Nataro, Pieścik-Lech, Pitkin, Rao, Rautenberg, Riddle, Salazar-Lindo, Sands, Santos, Savitha, Szajewska, Tebruegge, Tormo, Turck   +31 more
core   +1 more source

Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis

PLoS ONE, 2021
A treatment option for constipation that improves the quality of life is needed since available laxatives do not effectively improve the quality of life in patients with constipation.
Yutaka Makizaki, Taiki Uemoto, Haruka Yokota, Miyuki Yamamoto, Yoshiki Tanaka, H. Ohno   +5 more
semanticscholar   +1 more source

Identifying Candidate Risk Factors for Prescription Drug Side Effects using Causal Contrast Set Mining [PDF]

, 2015
Big longitudinal observational databases present the opportunity to extract new knowledge in a cost effective manner. Unfortunately, the ability of these databases to be used for causal inference is limited due to the passive way in which the data are ...
Aickelin, Uwe, Guo, Zhaoyang, Reps, Jenna, Zhu, Haoyue   +3 more
core   +3 more sources

Therapeutic effects of Bombax ceiba flower aqueous extracts against loperamide-induced constipation in mice

Pharmaceutical Biology, 2022
Context Bombax ceiba Linnaeus (Bombacaceae) is known as silk cotton tree, the flowers of which are used in many medicinal applications. Objective To investigate the therapeutic effect of B.
Liuping Wang, Shi-Jason Xie, Xuan Jiang, Caini Xu, Youqiong Wang, Jianfang Feng, Bin Yang   +6 more
semanticscholar   +1 more source

A Systematic Review of therapeutic agents for the treatment of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [PDF]

, 2019
Background The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first described in 2012 and attracted a great international attention due to multiple healthcare associated outbreaks.
Al-Ali, Anfal Y., Al-Tawfiq, Jaffar A., Momattin, Hisham   +2 more
core   +1 more source

Modulation of Tau Protein Neurotoxic Hallmarks by Novel σ1R Agonists/HDAC Inhibitor Dual‐Acting Compounds [PDF]

ChemMedChem
This study explores the development of dual‐acting compounds combining σ1R agonists and histone deacetylase inhibitors (HDACi). Key findings include compound 2d and 3a's high affinity for σ1R and favorable pharmacokinetic profile and an in vivo determined σ1R agonist profile by reversing the effect of the σ1R antagonist BD‐1063.
Fallica A, Barbaraci C, Ruiz‐Cantero M, Scarlatti A, Coco A, Giordano G, La Mantia A, Prezzavento O, Di Stefano A, Cacciatore I, Siano G, Cattaneo A, Pasquinucci L, Cobos E, Di Primio C, Amata E, Marrazzo A.   +16 more
europepmc   +2 more sources