Results 61 to 70 of about 16,722 (204)

Final findings from the CONTROL trial: Strategies to reduce the incidence and severity of neratinib-associated diarrhea in patients with HER2-positive early-stage breast cancer

Breast, 2023
Background: Neratinib is an irreversible pan-HER tyrosine kinase inhibitor approved for HER2-positive early-stage and metastatic breast cancer. Diarrhea is the most frequent side effect and the most common reason for early discontinuation.
Arlene Chan, Manuel Ruiz-Borrego, Gavin Marx, A. Jo Chien, Hope S. Rugo, Adam Brufsky, Michael Thirlwell, Maureen Trudeau, Ron Bose, José A. García-Sáenz, Daniel Egle, Barbara Pistilli, Johanna Wassermann, Kerry A. Cheong, Benjamin Schnappauf, Dieter Semsek, Christian F. Singer, Navid Foruzan, Daniel DiPrimeo, Leanne McCulloch, Sara A. Hurvitz, Carlos H. Barcenas   +21 more
doaj   +1 more source

A Review of the Role of Melatonin in Irritable Bowel Syndrome [PDF]

, 2014
Irritable bowel syndrome (IBS) is a troubling disease experienced worldwide. The presentation of symptoms varies from patient to patient, and current prescription treatments can be inadequate in resolving symptoms.
Brinn, Nicole R., Gandhi, Mona A.
core   +1 more source

The pattern of symptoms in patients receiving home based care in Bangwe, Malawi : a descriptive study [PDF]

, 2006
BackgroundHome based care of HIV/AIDS patients is a health need recommended but not often available in Africa. Population based assessment helps to identify unmet health needs to plan services.
Cameron Bowie, Claire Bowie, Linda Kalilane, Paul Cleary   +3 more
core   +2 more sources

Medication prescription patterns in cancer rehabilitation physiatry outpatients: A multicenter retrospective study

PM&R, EarlyView.
Abstract Background and Objective Previous work from this dataset found 45% prescribing frequency of any medications (35.1%, 33.5%, and 56.8% at institutions 1, 2, and 3 respectively), without significant difference between in‐person and telemedicine.
Matthew Chen, Nafis Eghrari, David Leong, Philip Chang, Jasmine Zheng, Amy Ng, Richard Wilson, Mary Vargo   +7 more
wiley   +1 more source

Determination of Pathophysiological Anti-Diarrhoeal Activity of the Aqueous Stem Bark Extract of Ficus platyphylla

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2022
This study was motivated by the report of a survey of herbal remedies used by Fulani herdsmen in the management of cow diarrhoea in Plateau State, Nigeria. The report identified F. platyphylla stem bark amongst major herbs.
Adisa Jimoh, Olatunji Gabriel, Akanbi Hass, Fabiyi Oluwatoyin, Zakariyah Ramat   +4 more
doaj   +1 more source

A mini‐review of chronic suppression of the hypothalamic–pituitary–adrenal axis in animals with P‐glycoprotein deficiency

Journal of Small Animal Practice, EarlyView.
This mini‐review describes the pathophysiology of the disrupted hypothalamic–pituitary–adrenal axis in dogs, and probably cats, with the MDR1 (ABCB1) mutation, ABCB1‐1Δ in dogs and ABCB11930‐1931del TC in cats. Clinical consequences in affected animals are discussed and therapeutic interventions to consider are presented.
K. L. Mealey
wiley   +1 more source

Loperamide [PDF]

Journal of Pain and Symptom Management, 2011
Claud, Regnard, Robert, Twycross, Mary, Mihalyo, Andrew, Wilcock   +3 more
openaire   +3 more sources

Functional Characterization of the Cat and Dog Wild‐Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Lisa Siegl, Mies Bethäuser, Daniela Nürnberger, Stefan Oswald, Andreas Moritz, Melanie Hamann, Joachim Geyer   +6 more
wiley   +1 more source

Loperamide increases mouse gut transit time in a dose-dependent manner with treatment duration-dependent effects on distinct gut microbial taxa

Gut Microbiome
Intestinal transit time has been recognized as an important factor in shaping the gut microbiota, although causality remains to be firmly demonstrated. The aim of this study was to evaluate the effect of different loperamide doses on the mouse intestinal
Anna Pii Hjørne, Martin Steen Mortensen, Tine Rask Licht, Martin Frederik Laursen   +3 more
doaj   +1 more source

Dorsal Genital Nerve Stimulation in Patients With Fecal Incontinence and Fecal Urgency: A Feasibility Study With the Novel UCon Neurostimulator

Neurogastroenterology &Motility, EarlyView.
Dorsal genital nerve stimulation with the UCon neurostimulator was found to be safe and feasible. A 4‐week period of home stimulation resulted in a reduction of fecal incontinence episodes, a decrease in strong urgency episodes, and an improvement in bowel‐related questionnaires.
Louise Schmidt Grau, Peter Christensen, Niels Qvist, Niels Klarskov, Nico Rijkhoff, Jakob Duelund‐Jakobsen   +5 more
wiley   +1 more source