Results 51 to 60 of about 22,601 (285)

Loperamide cases reported to United States poison centers, 2010–2022

Injury Epidemiology, 2023
Background Intentional use of high doses of loperamide has been linked to serious cardiac toxicity. The objective of this study is to investigate the characteristics and trends of loperamide cases reported to United States (US) poison centers and to ...
Aaditya Patel, Natalie I. Rine, Henry A. Spiller, Hannah Hays, Jaahnavi Badeti, Motao Zhu, Kele Ding, Gary A. Smith   +7 more
doaj   +1 more source

Quantitative proteomic analysis reveals the effects of mu opioid agonists on HT22 cells

Frontiers in Pharmacology, 2023
Introduction: At present, the mu opioid receptor is the most important neuroaesthetics receptor in anesthesiology research, and the damage that it does to the nervous system is unknown.Methods: We investigated the effects of loperamide, an agonist of the
Xutong Zhang, Yani Lou, Dongxu Zheng, Jialin Lu, Dansi Qi   +4 more
doaj   +1 more source

Antioxidant activity and laxative effects of tannin-enriched extract of Ecklonia cava in loperamide-induced constipation of SD rats

PLoS ONE, 2021
To investigate the role of tannin-enriched extracts of Ecklonia cava (TEE) on the regulation of oxidative balance and laxative activity in chronic constipation, we investigated alterations after exposure to TEE, on constipation phenotypes, muscarinic ...
J. Kim, Y. Choi, Su Jin Lee, J. Gong, Young Ju Lee, J. Sung, Young-Suk Jung, H. Lee, J. Hong, D. Hwang   +9 more
semanticscholar   +1 more source

‘ Loperamide overdose induces ventricular tachycardia with catastrophic outcomes’

Journal of Community Hospital Internal Medicine Perspectives, 2020
Loperamide is a widely available, over-the-counter medication. The advent of the opioid epidemic has seen cases of loperamide overdose being reported. The common side effects of the medication can be relatively benign, but at high doses, loperamide can ...
Zain Ali, Umer Shoukat, Mariya Khan, Sohaib Roomi, Waqas Ullah   +4 more
doaj   +1 more source

A life-threatening ventricular arrhythmia secondary to loperamide abuse, “a poor man’s methadone”

Heart Vessels and Transplantation, 2021
The case of a patient with repetitive syncope episodes with a history of using loperamide at high doses for recreational purposes in search of an effect similar to heroin, is reported.
Miguel A. Rojas Carrera, Juan Guzman Olea, Gabriel Guzman Olea, Ernesto Hernandez Jimenez   +3 more
doaj   +1 more source

Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death

bioRxiv, 2020
Increasing evidence suggests that induction of lethal autophagy carries potential significance for the treatment of glioblastoma (GBM). In continuation of previous work, we demonstrate that pimozide and loperamide trigger an ATG5- and ATG7-dependent type
Nina Meyer, Lisa Henkel, B. Linder, Svenja Zielke, G. Tascher, S. Trautmann, G. Geisslinger, Christian Münch, S. Fulda, I. Tegeder, D. Kögel   +10 more
semanticscholar   +1 more source

Identifying Candidate Risk Factors for Prescription Drug Side Effects using Causal Contrast Set Mining [PDF]

, 2015
Big longitudinal observational databases present the opportunity to extract new knowledge in a cost effective manner. Unfortunately, the ability of these databases to be used for causal inference is limited due to the passive way in which the data are ...
Aickelin, Uwe, Guo, Zhaoyang, Reps, Jenna, Zhu, Haoyue   +3 more
core   +3 more sources

A Systematic Review of therapeutic agents for the treatment of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [PDF]

, 2019
Background The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first described in 2012 and attracted a great international attention due to multiple healthcare associated outbreaks.
Al-Ali, Anfal Y., Al-Tawfiq, Jaffar A., Momattin, Hisham   +2 more
core   +1 more source

Citric Acid-Enriched Extract of Ripe Prunus mume (Siebold) Siebold & Zucc. Induces Laxative Effects by Regulating the Expression of Aquaporin 3 and Prostaglandin E2 in Rats with Loperamide-Induced Constipation

Journal of Medicinal Food, 2022
Previously, we demonstrated that extracts of the ripe fruit (rPM) and unripe fruit (uPM) of Prunus mume (Siebold) Siebold & Zucc. and citric acid have a laxative effect, which is at least partially mediated by the increase in fecal parameters as seen in ...
Ju-ryun Na, Eun Kim, C. Na, Sunoh Kim
semanticscholar   +1 more source

Causes and assessment of faecal incontinence [PDF]

, 1999
Faecal incontinence remains a taboo subject and patients frequently conceal their symptoms, because of fear and embarrassment. Sensitive and appropriate assessment will encourage people to seek advice and treatment if required. This article discusses the
Chelvanayagam, Sonya
core   +1 more source