Results 81 to 90 of about 17,797 (277)

Loperamide cardiotoxicity: “A Brief Review” [PDF]

Annals of Noninvasive Electrocardiology, 2017
Loperamide is a popular antidiarrheal medication that has been used for many years. It is currently gaining more attention among healthcare professionals due to its increasing potential for side effects. At present, it is considered safe enough to be sold over the counter.
Tamer Akel, Soad Bekheit
openaire   +2 more sources

Ten‐Year Outcomes of Anticholinergic Use Among Older Adults With Intellectual Disability: Findings From the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS‐TILDA)

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background People with intellectual disability are frequently exposed to medication with anticholinergic activity. In the general population, the long‐term exposure to anticholinergics has been associated with declines in both physical and cognitive function.
Lamya Al Shuhaimi, Ian D. Maidment, Martin C. Henman, Phyo K. Myint, Juliette O'Connell, Caitríona Ryan, Philip McCallion, Mary McCarron, Maire O'Dwyer   +8 more
wiley   +1 more source

Controversies in NEN: An ENETS position statement on nutritional support in neuroendocrine neoplasms

Journal of Neuroendocrinology, EarlyView.
Abstract Neuroendocrine neoplasms (NEN) themselves and also their treatment may cause malnutrition, inducing changes in physiological behaviour and eventually leading to increased rates of morbidity and mortality. Malnutrition is a common, under‐recognised and under‐treated condition in patients with NEN, and there are limited data available on the ...
Simona Grozinsky‐Glasberg, Johannes Hofland, Stephanie Alband, Yasmin Chotai de Lima, Adina Croitoru, Wanda Geilvoet, Peter Igaz, Beata Kos‐Kudła, Guenter J. Krejs, Alessandro Laviano, Francesco Panzuto, Anguraj Sadanandam, Ana Paula Santos, Staffan Welin, Rajaventhan Srirajaskanthan, V. Ambrosini, D. K. Bartsch, E. Baudin, N. Begum, E. Christ, J. Cros, T. Denecke, C. M. Deroose, C. Dromain, M. Falconi, N. Fazio, L. Fernandez‐Cuesta, R. Garcia‐Carbonero, A. Grossman, G. Kaltsas, A. Kasajima, A. Kjaer, G. Klöppel, U. P. Knigge, A. Lamarca, S. W. Langer, T. V. Luong, W. Martin, M. McNamara, D. O'Toole, S. Partelli, M. Pavel, A. Perren, R. Salazar, J. Schrader, H. Sorbye, A. Sowa‐Staszczak, E.‐J. Speel, P. Stalberg, M. Tesselaar, E. Tiensuu Janson, M. Tsoli, M. Volante, T. Walter   +53 more
wiley   +1 more source

Repurposing loperamide to overcome gefitinib resistance by triggering apoptosis independent of autophagy induction in KRAS mutant NSCLC cells

Cancer Treatment and Research Communications, 2020
Background: Gefitinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) approved for first-line treatment of non-small cell lung cancer (NSCLC) with sensitizing EGFR mutations.
Christy W.S. Tong, Mia M.X. Wu, Vivi W. Yan, William C.S. Cho, Kenneth K.W. To   +4 more
doaj   +1 more source

Possible Role of Butyric Acid in Long‐Term Symptom Relief in Irritable Bowel Syndrome Patients Following Fecal Microbiota Transplantation

Neurogastroenterology &Motility, EarlyView.
Fecal butyric acid levels increased in IBS patients at 2 and 3 years after FMT and were inverse correlation with both IBS symptoms and fatigue suggesting that butyric acid contributes to the long‐term improvement seen after FMT. ABSTRACT Background We previously found that the fecal levels of short‐chain fatty acids (SCFAs) changed in irritable bowel ...
Magdy El‐Salhy, Jørgen Valeur, Ingeborg Brønstad, Odd Helge Gilja, Jan Gunnar Hatlebakk   +4 more
wiley   +1 more source

Quantification of Dynamic 11C-Phenytoin PET Studies [PDF]

, 2015
The overexpression of P-glycoprotein (Pgp) is thought to be an important mechanism of pharmacoresistance in epilepsy. Recently, 11C-phenytoin has been evaluated preclinically as a tracer for Pgp.
Bakker, Esther D.M., Boellaard, Ronald, Froklage, Femke E., Lammertsma, Adriaan, Mansor, Mohd Syahir, Schwarte, Lothar A., Verbeek, Joost, Voskuyl, Rob A., Windhorst, Albert D., Yaqub, Maqsood   +9 more
core   +1 more source

Topical Loperamide-Encapsulated Liposomal Gel Increases the Severity of Inflammation and Accelerates Disease Progression in the Adjuvant-Induced Model of Experimental Rheumatoid Arthritis

Frontiers in Pharmacology, 2017
This study evaluates the prophylactic effect of the peripherally-selective mu-opioid receptor agonist, loperamide, administered topically in a liposomal gel formulation on pain, inflammation, and disease progression in the adjuvant-induced model of ...
Susan Hua, Susan Hua, Thilani H. Dias, Debbie-Gai Pepperall, Yuan Yang   +4 more
doaj   +1 more source

Efficacy and Safety of the Enterosorbent Silicolgel in Irritable Bowel Syndrome, IBS‐D and IBS‐M: A Randomized, Double‐Blind, Placebo‐Controlled, Multi‐Center Trial

Neurogastroenterology &Motility, EarlyView.
Current treatments often fall short in managing IBS effectively. Silicolgel, an enterosorbent, reduced IBS and other gastrointestinal symptoms in 90% of IBS patients compared to 20% in those on placebo. Enterosorbents are not currently recommended for IBS; silicolgel is a widely available, affordable option for patients with IBS‐D and IBS‐M.
O. Kuzminska, B. Vitkovska, Yurii Kuvaiskov, Chris G. Hatton   +3 more
wiley   +1 more source

Worldwide Efficacy of Bismuth Subsalicylate in the Treatment of Travelers' Diarrhea [PDF]

, 2017
So far four randomized studies, three of them double-blind and placebo-controlled, have investigated the role of bismuth subsalicylate (BSS) in the treatment of travelers' diarrhea.
Steffen, Robert
core  

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source