Results 1 to 10 of about 42,220 (210)

Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model

Radiation Oncology, 2021
Background Patients with metastatic HER2/neu-positive (HER2/neu +) breast cancer (BC) often experience treatment resistance, disease recurrences and metastases.
Wende Li, Sen Li, Ivy X. Chen, Yujiao Liu, Rakesh R. Ramjiawan, Chi-Ho Leung, Leo E. Gerweck, Dai Fukumura, Jay S. Loeffler, Rakesh K. Jain, Dan G. Duda, Peigen Huang   +11 more
doaj   +2 more sources

Effects of gut microbiota dysbiosis on the metabolism and pharmacokinetics of losartan in rats: from endogenous to ceftriaxone-induced dysbiosis [PDF]

Frontiers in Microbiology
IntroductionGut microbiota plays a key role in drug metabolism. While gut microbiota dysbiosis is known to contribute to hypertension pathogenesis, its impact on drug metabolism remains poorly considered.
Jiaxuan Xia, Jiaxuan Xia, Jiaxuan Xia, Yibao Jin, Yanjun Hong, Yuefeng Zhang, Meifang Li, Houshuang Huang, Xu Cai, Dan Li, Bing Wang, Zhiyong Xie   +11 more
doaj   +2 more sources

Losartan alleviated synovitis in patients with metabolic osteoarthritis by down-regulating AT1R to inhibit TGF-β signaling [PDF]

Journal of Orthopaedic Surgery and Research
Previous studies have shown that losartan can alleviate the progression of osteoarthritis (OA). This study aimed to further explore the therapeutic effect and mechanism of losartan on metabolic OA.
Haonan Zhang, Jiayong Zhu, Hangyuan He, Bin Li, Hui Wang, Liaobin Chen, Qubo Ni   +6 more
doaj   +2 more sources

Modulating the tumor microenvironment improves antitumor effect of anti-PD-L1 mAb in breast cancer [PDF]

BioImpacts, 2023
Introduction: Immune checkpoint inhibitors (ICIs) have provided noteworthy benefits in multiple cancer patients. However, the efficacy of monotherapy of ICIs was very limited.
Xiuying Li, Xianqin Luo, Shunqin Hu
doaj   +1 more source

Synergy of Losartan and chemotherapy for patients with cholangiocarcinoma: A propensity score-matched analysis

Frontiers in Oncology, 2022
BackgroundCholangiocarcinoma (CCA) is a malignant tumor originating from bile duct epithelial cells that no obvious clinical symptoms and specific clinical manifestations are shown in the early stage of CCA.MethodsPropensity score matching (PSM) is a ...
Qing Li, Zhenyu Chang, Zhenyu Chang, Tianyi Wang, Bing Liu, Ximin Wang, Xin-Yu Ge, Tao Yang, Qu Liu, Qu Liu, Wei Wang   +10 more
doaj   +1 more source

Changes in Pharmacokinetics and Pharmacodynamics of Losartan in Experimental Diseased Rats Treated with Curcuma longa and Lepidium sativum

Pharmaceuticals, 2022
The current study investigated “pharmacodynamics and pharmacokinetics interactions” of losartan with Curcuma longa (CUR) and Lepidium sativum (LS) in hypertensive rats.
Abdul Ahad, Mohammad Raish, Ibrahim Abdelsalam Abdelrahman, Yousef A. Bin Jardan, Mohd Aftab Alam, Abdullah M. Al-Mohizea, Fahad I. Al-Jenoobi   +6 more
doaj   +1 more source

Trityl Losartan [PDF]

ChemInform, 2004
The title compound (systematic name: [2-butyl-4-chloro-1-[2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-yl]methanol), C(41)H(37)ClN(6)O, crystallizes in the centrosymmetric space group P-1 with two independent molecules in the asymmetric unit.
Sieron, L., Nagaraj, B., Prabhuswamy, B., Yathirajan, H. S., Nagaraja, P., Narasegowda, R. S., Gaonkar, Santosh L.   +6 more
openaire   +2 more sources

COVIDMED – An early pandemic randomized clinical trial of losartan treatment for hospitalized COVID-19 patients

Contemporary Clinical Trials Communications, 2022
Objectives: To assess the efficacy and safety of losartan for COVID-19 patients. Methods: COVIDMED was a double-blinded, placebo-controlled platform RCT.
Daniel Freilich, Jennifer Victory, Paul Jenkins, Anne Gadomski   +3 more
doaj   +1 more source

Bioequivalence study of fixed-dose combination Losartan + amlodipine + rosuvastatin Sanofi in comparison with coadministered fixed- dose combination Lozap® AM and monocomponent drug Crestor® in healthy subjects

Фармакокинетика и Фармакодинамика, 2022
Introduction. The advantages of fixed-dose combination losartan + amlodipine + rosuvastatin compared to mono-drugs and two-component combinations are to increase the therapeutic efficacy, to reduce the cost of the product and to make the drug easier to ...
A. L. Khokhlov, D. Yu. Grebenkin, E. K. Faeva, V. I. Kazey, A. A. Khokhlov, A. E. Miroshnikov, O. V. Lebedeva   +6 more
doaj   +1 more source

P50 The Administration of Losartan/Amlodipine in Fixed Combination Versus Losartan Improves the Hemodynamic and Arterial Stiffness Parameters in Patients with Systemic Hypertension Grade 1 and 2

Artery Research, 2020
Purpose/Background/Objectives: Hypertension (HAS) represents 9.4 million deaths from all the cases of cardiovascular disease worldwide [1]. The pulse wave velocity (PWV) and some hemodynamic parameters have been associated with this outcome [2,3 ...
Mayra Jimenez, Fernando Grover, Marycruz Barocio, Ernesto Cardona, Patricia Quezada, Jhonatan Trujillo, David Cardona, Carlos Ramos   +7 more
doaj   +1 more source