Results 1 to 10 of about 73,633 (314)

Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model

open access: yesRadiation Oncology, 2021
Background Patients with metastatic HER2/neu-positive (HER2/neu +) breast cancer (BC) often experience treatment resistance, disease recurrences and metastases.
Wende Li   +11 more
doaj   +2 more sources

Modulating the tumor microenvironment improves antitumor effect of anti-PD-L1 mAb in breast cancer [PDF]

open access: yesBioImpacts, 2023
Introduction: Immune checkpoint inhibitors (ICIs) have provided noteworthy benefits in multiple cancer patients. However, the efficacy of monotherapy of ICIs was very limited.
Xiuying Li, Xianqin Luo, Shunqin Hu
doaj   +1 more source

Synergy of Losartan and chemotherapy for patients with cholangiocarcinoma: A propensity score-matched analysis

open access: yesFrontiers in Oncology, 2022
BackgroundCholangiocarcinoma (CCA) is a malignant tumor originating from bile duct epithelial cells that no obvious clinical symptoms and specific clinical manifestations are shown in the early stage of CCA.MethodsPropensity score matching (PSM) is a ...
Qing Li   +10 more
doaj   +1 more source

Changes in Pharmacokinetics and Pharmacodynamics of Losartan in Experimental Diseased Rats Treated with Curcuma longa and Lepidium sativum

open access: yesPharmaceuticals, 2022
The current study investigated “pharmacodynamics and pharmacokinetics interactions” of losartan with Curcuma longa (CUR) and Lepidium sativum (LS) in hypertensive rats.
Abdul Ahad   +6 more
doaj   +1 more source

Trityl Losartan [PDF]

open access: yesChemInform, 2004
The title compound (systematic name: [2-butyl-4-chloro-1-[2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-yl]methanol), C(41)H(37)ClN(6)O, crystallizes in the centrosymmetric space group P-1 with two independent molecules in the asymmetric unit.
Sieron, L.   +6 more
openaire   +2 more sources

Bioequivalence study of fixed-dose combination Losartan + amlodipine + rosuvastatin Sanofi in comparison with coadministered fixed- dose combination Lozap® AM and monocomponent drug Crestor® in healthy subjects

open access: yesФармакокинетика и Фармакодинамика, 2022
Introduction. The advantages of fixed-dose combination losartan + amlodipine + rosuvastatin compared to mono-drugs and two-component combinations are to increase the therapeutic efficacy, to reduce the cost of the product and to make the drug easier to ...
A. L. Khokhlov   +6 more
doaj   +1 more source

Effectiveness of Losartan-Loaded Hyaluronic Acid (HA) Micelles for the Reduction of Advanced Hepatic Fibrosis in C3H/HeN Mice Model. [PDF]

open access: yesPLoS ONE, 2015
Advanced hepatic fibrosis therapy using drug-delivering nanoparticles is a relatively unexplored area. Angiotensin type 1 (AT1) receptor blockers such as losartan can be delivered to hepatic stellate cells (HSC), blocking their activation and thereby ...
Reju George Thomas   +4 more
doaj   +1 more source

Losartan Inhibits SARS-CoV-2 Replication in Vitro

open access: yesJournal of Pharmacy & Pharmaceutical Sciences, 2021
Purpose: SARS-CoV-2 infection is associated with substantial mortality and high morbidity. This study tested the effect of angiotensin II type I receptor blocker, losartan, on SARS-CoV-2 replication and inhibition of the papain-like protease of the virus.
Reza Nejat   +6 more
doaj   +1 more source

P50 The Administration of Losartan/Amlodipine in Fixed Combination Versus Losartan Improves the Hemodynamic and Arterial Stiffness Parameters in Patients with Systemic Hypertension Grade 1 and 2

open access: yesArtery Research, 2020
Purpose/Background/Objectives: Hypertension (HAS) represents 9.4 million deaths from all the cases of cardiovascular disease worldwide [1]. The pulse wave velocity (PWV) and some hemodynamic parameters have been associated with this outcome [2,3 ...
Mayra Jimenez   +7 more
doaj   +1 more source

Exercise training and losartan improve endothelial function in heart failure rats by different mechanisms [PDF]

open access: yes, 2013
Objectives. To investigate the mechanisms of losartan- and exercise training-induced improvements on endothelial dysfunction in heart failure. Design. Sprague-Dawley rats subjected to left coronary artery ligation inducing myocardial infarction and heart
Crozier I   +5 more
core   +1 more source

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