Results 1 to 10 of about 72,849 (316)
Radiation Oncology, 2021 Background Patients with metastatic HER2/neu-positive (HER2/neu +) breast cancer (BC) often experience treatment resistance, disease recurrences and metastases.
Wende Li +11 more
doaj +2 more sources
Modeling the Influence of CYP2C9 and ABCB1 Gene Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Losartan [PDF]
PharmaceuticsBackground/Objectives: Hypertension is a pathological condition characterized by elevated systolic and/or diastolic blood pressure. A range of pharmacotherapeutic agents are available to treat this condition and prevent complications, including the ...
Dmitry Babaev +2 more
doaj +2 more sources
Optimizing Blood Pressure Control: A Randomized Comparative Trial of Losartan/Chlorthalidone vs. Losartan/Hydrochlorothiazide [PDF]
Cardiology and TherapyIntroduction Cardiovascular diseases are a leading cause of global mortality, with hypertension as a major risk factor. Low control rates are often attributed to monotherapy, while evidence and clinical guidelines support the effectiveness of combination
Isabel E. Rucker-Joerg +8 more
doaj +2 more sources
Modulating the tumor microenvironment improves antitumor effect of anti-PD-L1 mAb in breast cancer [PDF]
BioImpacts, 2023 Introduction: Immune checkpoint inhibitors (ICIs) have provided noteworthy benefits in multiple cancer patients. However, the efficacy of monotherapy of ICIs was very limited.
Xiuying Li, Xianqin Luo, Shunqin Hu
doaj +1 more source
Frontiers in Oncology, 2022 BackgroundCholangiocarcinoma (CCA) is a malignant tumor originating from bile duct epithelial cells that no obvious clinical symptoms and specific clinical manifestations are shown in the early stage of CCA.MethodsPropensity score matching (PSM) is a ...
Qing Li +10 more
doaj +1 more source
ChemInform, 2004 The title compound (systematic name: [2-butyl-4-chloro-1-[2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-yl]methanol), C(41)H(37)ClN(6)O, crystallizes in the centrosymmetric space group P-1 with two independent molecules in the asymmetric unit.
Sieron, L. +6 more
openaire +2 more sources
Pharmaceuticals, 2022 The current study investigated “pharmacodynamics and pharmacokinetics interactions” of losartan with Curcuma longa (CUR) and Lepidium sativum (LS) in hypertensive rats.
Abdul Ahad +6 more
doaj +1 more source
Effectiveness of Losartan-Loaded Hyaluronic Acid (HA) Micelles for the Reduction of Advanced Hepatic Fibrosis in C3H/HeN Mice Model. [PDF]
PLoS ONE, 2015 Advanced hepatic fibrosis therapy using drug-delivering nanoparticles is a relatively unexplored area. Angiotensin type 1 (AT1) receptor blockers such as losartan can be delivered to hepatic stellate cells (HSC), blocking their activation and thereby ...
Reju George Thomas +4 more
doaj +1 more source
Фармакокинетика и Фармакодинамика, 2022 Introduction. The advantages of fixed-dose combination losartan + amlodipine + rosuvastatin compared to mono-drugs and two-component combinations are to increase the therapeutic efficacy, to reduce the cost of the product and to make the drug easier to ...
A. L. Khokhlov +6 more
doaj +1 more source
Losartan Inhibits SARS-CoV-2 Replication in Vitro
Journal of Pharmacy & Pharmaceutical Sciences, 2021 Purpose: SARS-CoV-2 infection is associated with substantial mortality and high morbidity. This study tested the effect of angiotensin II type I receptor blocker, losartan, on SARS-CoV-2 replication and inhibition of the papain-like protease of the virus.
Reza Nejat +6 more
doaj +1 more source