Results 1 to 10 of about 28,178 (179)

Systematic Review of Management Strategies for Alport Syndrome: Implications for Male Patients. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Alport Syndrome (AS) is a rare genetic disorder characterized by progressive kidney disease, hearing loss, and ocular abnormalities, with an incidence of approximately 1 in 50,000 newborns. Due to the severity of the disease, particularly in males with X‐linked inheritance, this systematic review consolidates current ...
Sarfraz Z, Khan A, Liaqat M, Khan A, Javad F, Saleem M, Sarfraz A, Khalid M, Sarfraz M, Kc M, Irfan O.   +10 more
europepmc   +2 more sources

Modulating the tumor microenvironment improves antitumor effect of anti-PD-L1 mAb in breast cancer [PDF]

BioImpacts, 2023
Introduction: Immune checkpoint inhibitors (ICIs) have provided noteworthy benefits in multiple cancer patients. However, the efficacy of monotherapy of ICIs was very limited.
Xiuying Li, Xianqin Luo, Shunqin Hu
doaj   +1 more source

Synergy of Losartan and chemotherapy for patients with cholangiocarcinoma: A propensity score-matched analysis

Frontiers in Oncology, 2022
BackgroundCholangiocarcinoma (CCA) is a malignant tumor originating from bile duct epithelial cells that no obvious clinical symptoms and specific clinical manifestations are shown in the early stage of CCA.MethodsPropensity score matching (PSM) is a ...
Qing Li, Zhenyu Chang, Zhenyu Chang, Tianyi Wang, Bing Liu, Ximin Wang, Xin-Yu Ge, Tao Yang, Qu Liu, Qu Liu, Wei Wang   +10 more
doaj   +1 more source

A remote hypertension management program clinical algorithm

Clinical Cardiology, Volume 45, Issue 12, Page 1147-1162, December 2022., 2022
Abstract Introduction Hypertension is the leading risk factor for death, affecting over one billion people worldwide, yet control rates are poor and stagnant. We developed a remote hypertension management program that leverages digitally transmitted home blood pressure (BP) measurements, algorithmic care pathways, and patient–navigator communications ...
Hunter Nichols, Christopher P. Cannon, Benjamin M. Scirica, Naomi D. L. Fisher   +3 more
wiley   +1 more source

Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model

Radiation Oncology, 2021
Background Patients with metastatic HER2/neu-positive (HER2/neu +) breast cancer (BC) often experience treatment resistance, disease recurrences and metastases.
Wende Li, Sen Li, Ivy X. Chen, Yujiao Liu, Rakesh R. Ramjiawan, Chi-Ho Leung, Leo E. Gerweck, Dai Fukumura, Jay S. Loeffler, Rakesh K. Jain, Dan G. Duda, Peigen Huang   +11 more
doaj   +1 more source

Changes in Pharmacokinetics and Pharmacodynamics of Losartan in Experimental Diseased Rats Treated with Curcuma longa and Lepidium sativum

Pharmaceuticals, 2022
The current study investigated “pharmacodynamics and pharmacokinetics interactions” of losartan with Curcuma longa (CUR) and Lepidium sativum (LS) in hypertensive rats.
Abdul Ahad, Mohammad Raish, Ibrahim Abdelsalam Abdelrahman, Yousef A. Bin Jardan, Mohd Aftab Alam, Abdullah M. Al-Mohizea, Fahad I. Al-Jenoobi   +6 more
doaj   +1 more source

Association of demographic and clinical factors with risk of acute pancreatitis: An exposure‐wide Mendelian randomization study

Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023
The incidence of acute pancreatitis is increasing over years especially in western countries, but the etiologies of acute pancreatitis have not been well understood. And it is unclear whether the reported possible risk factors are real causes of acute pancreatitis.
Qiu‐Yi Tang, Qi Yang, Xian‐Qiang Yu, Yu‐Xiu Liu, Zhi‐Hui Tong, Bai‐Qiang Li, Ya‐Ting Chen, Evan Yi‐Wen Yu, Wei‐Qin Li   +8 more
wiley   +1 more source

Bioequivalence study of fixed-dose combination Losartan + amlodipine + rosuvastatin Sanofi in comparison with coadministered fixed- dose combination Lozap® AM and monocomponent drug Crestor® in healthy subjects

Фармакокинетика и Фармакодинамика, 2022
Introduction. The advantages of fixed-dose combination losartan + amlodipine + rosuvastatin compared to mono-drugs and two-component combinations are to increase the therapeutic efficacy, to reduce the cost of the product and to make the drug easier to ...
A. L. Khokhlov, D. Yu. Grebenkin, E. K. Faeva, V. I. Kazey, A. A. Khokhlov, A. E. Miroshnikov, O. V. Lebedeva   +6 more
doaj   +1 more source

Incidence and preventability of hospital admissions for adverse drug reactions in France: A prospective observational study (IATROSTAT)

British Journal of Clinical Pharmacology, Volume 89, Issue 1, Page 390-400, January 2023., 2023
Aims In the last French study in 2007, the incidence of hospital admissions (HAs) related to adverse drug reactions (ADRs) was 3.6%. The objective was to assess the current ADR‐HA incidence in France and to describe both its characteristics and preventability.
Marie‐Laure Laroche, Sophie Gautier, Elisabeth Polard, Marie‐Blanche Rabier, Laurent Chouchana, Bénédicte Lebrun‐Vignes, Jean‐Luc Faillie, Nadine Petitpain, Laurence Lagarce, Annie‐Pierre Jonville‐Bera, for the IATROSTAT study group   +10 more
wiley   +1 more source

Effectiveness of Losartan-Loaded Hyaluronic Acid (HA) Micelles for the Reduction of Advanced Hepatic Fibrosis in C3H/HeN Mice Model. [PDF]

PLoS ONE, 2015
Advanced hepatic fibrosis therapy using drug-delivering nanoparticles is a relatively unexplored area. Angiotensin type 1 (AT1) receptor blockers such as losartan can be delivered to hepatic stellate cells (HSC), blocking their activation and thereby ...
Reju George Thomas, Myeong Ju Moon, Jo Heon Kim, Jae Hyuk Lee, Yong Yeon Jeong   +4 more
doaj   +1 more source