Results 11 to 20 of about 58,845 (265)
Effectiveness of Losartan-Loaded Hyaluronic Acid (HA) Micelles for the Reduction of Advanced Hepatic Fibrosis in C3H/HeN Mice Model. [PDF]
PLoS ONE, 2015 Advanced hepatic fibrosis therapy using drug-delivering nanoparticles is a relatively unexplored area. Angiotensin type 1 (AT1) receptor blockers such as losartan can be delivered to hepatic stellate cells (HSC), blocking their activation and thereby ...
Reju George Thomas +4 more
doaj +3 more sources
Effects of gut microbiota dysbiosis on the metabolism and pharmacokinetics of losartan in rats: from endogenous to ceftriaxone-induced dysbiosis [PDF]
Frontiers in MicrobiologyIntroductionGut microbiota plays a key role in drug metabolism. While gut microbiota dysbiosis is known to contribute to hypertension pathogenesis, its impact on drug metabolism remains poorly considered.
Jiaxuan Xia +11 more
doaj +2 more sources
Losartan alleviated synovitis in patients with metabolic osteoarthritis by down-regulating AT1R to inhibit TGF-β signaling [PDF]
Journal of Orthopaedic Surgery and ResearchPrevious studies have shown that losartan can alleviate the progression of osteoarthritis (OA). This study aimed to further explore the therapeutic effect and mechanism of losartan on metabolic OA.
Haonan Zhang +6 more
doaj +2 more sources
Modeling the Influence of CYP2C9 and ABCB1 Gene Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Losartan [PDF]
PharmaceuticsBackground/Objectives: Hypertension is a pathological condition characterized by elevated systolic and/or diastolic blood pressure. A range of pharmacotherapeutic agents are available to treat this condition and prevent complications, including the ...
Dmitry Babaev +2 more
doaj +2 more sources
Modulating the tumor microenvironment improves antitumor effect of anti-PD-L1 mAb in breast cancer [PDF]
BioImpacts, 2023 Introduction: Immune checkpoint inhibitors (ICIs) have provided noteworthy benefits in multiple cancer patients. However, the efficacy of monotherapy of ICIs was very limited.
Xiuying Li, Xianqin Luo, Shunqin Hu
doaj +1 more source
Frontiers in Oncology, 2022 BackgroundCholangiocarcinoma (CCA) is a malignant tumor originating from bile duct epithelial cells that no obvious clinical symptoms and specific clinical manifestations are shown in the early stage of CCA.MethodsPropensity score matching (PSM) is a ...
Qing Li +10 more
doaj +1 more source
Pharmaceuticals, 2022 The current study investigated “pharmacodynamics and pharmacokinetics interactions” of losartan with Curcuma longa (CUR) and Lepidium sativum (LS) in hypertensive rats.
Abdul Ahad +6 more
doaj +1 more source
ChemInform, 2004 The title compound (systematic name: [2-butyl-4-chloro-1-[2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-yl]methanol), C(41)H(37)ClN(6)O, crystallizes in the centrosymmetric space group P-1 with two independent molecules in the asymmetric unit.
Sieron, L. +6 more
openaire +2 more sources
Radiation Oncology, 2021 Background Patients with metastatic HER2/neu-positive (HER2/neu +) breast cancer (BC) often experience treatment resistance, disease recurrences and metastases.
Wende Li +11 more
doaj +1 more source
Contemporary Clinical Trials Communications, 2022 Objectives: To assess the efficacy and safety of losartan for COVID-19 patients. Methods: COVIDMED was a double-blinded, placebo-controlled platform RCT.
Daniel Freilich +3 more
doaj +1 more source