Results 21 to 30 of about 46,713 (174)

Temporal profile and mechanisms of the prompt sympathoexcitation following coronary ligation in Wistar rats [PDF]

open access: yes, 2014
Our aim was to assess the timing and mechanisms of the sympathoexcitation that occurs immediately after coronary ligation. We recorded thoracic sympathetic (tSNA) and phrenic activities, heart rate (HR) and perfusion pressure in Wistar rats subjected to ...
Abdala, Ana Paula   +5 more
core   +7 more sources

Effects of Ginkgo leaf tablets on the pharmacokinetics of losartan and its metabolite EXP3174 in rats and its mechanism

open access: yesPharmaceutical Biology, 2018
Context: Ginkgo leaf tablets (GLTs) and losartan are often simultaneously used for the treatment of hypertension in Chinese clinics. However, the herb–drug interaction between GLT and losartan is still unknown.
Baiping Dong   +3 more
doaj   +1 more source

Angiotensin II and VEGF are Involved in Angiogenesis Induced by Short-Term Exercise Training [PDF]

open access: yes, 2001
Results from our laboratory have suggested a pathway involving angiotensin II type 1 (AT1) receptors and vascular endothelial growth factor (VEGF) in angiogenesis induced by electrical stimulation.
Amaral, Sandra L.   +2 more
core   +2 more sources

Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-alpha2-deficient congenital muscular dystrophy (MDC1A) [PDF]

open access: yes, 2012
BACKGROUND: Laminin-alpha2-deficient congenital muscular dystrophy (MDC1A) is a severe muscle-wasting disease for which no curative treatment is available.
Lin, Shuo   +2 more
core   +1 more source

Neuroprotective Effect of Losartan after Traumatic Brain Injury in Male Rats Based on Marmarou Model

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2022
Background and Objective: Traumatic brain injury is the most important cause of death among young people in the world. Considering the neuroprotective effect of losartan on the recovery of brain damage, the present study was conducted to investigate the ...
Sh Shadi   +2 more
doaj  

Losartan Treatment Could Improve the Outcome of TBI Mice

open access: yesFrontiers in Neurology, 2020
Traumatic brain injury frequently leads to serious mortality and physical disability, yet effective treatments remains insufficient. TBI always leads to a series of secondary brain injuries including neuronal apoptosis, continuous inflammation ...
Jianhua Xiong   +7 more
doaj   +1 more source

Angiotensin-(1-7) increases osmotic water permeability in isolated toad skin [PDF]

open access: yes, 2000
Angiotensin-(1-7) (Ang-(1-7)) increased osmotic water permeability in the isolated toad skin, a tissue with functional properties similar to those of the distal mammalian nephron. Concentrations of 0.1 to 10 μM were effective, with a peak at 20 min. This
Coviello, Alfredo   +3 more
core   +4 more sources

COVIDMED – An early pandemic randomized clinical trial of losartan treatment for hospitalized COVID-19 patients

open access: yesContemporary Clinical Trials Communications, 2022
Objectives: To assess the efficacy and safety of losartan for COVID-19 patients. Methods: COVIDMED was a double-blinded, placebo-controlled platform RCT.
Daniel Freilich   +3 more
doaj  

Dissociation between the circulating renin-angiotensin system and angiotensin II receptors in central losartan-induced hypertension

open access: yesBrazilian Journal of Medical and Biological Research, 2002
Losartan, an AT1 angiotensin II (ANG II) receptor non-peptide antagonist, induces an increase in mean arterial pressure (MAP) when injected intracerebroventricularly (icv) into rats.
A.M. Sugawara   +5 more
doaj   +1 more source

Antihypertension Nanoblockers Increase Intratumoral Perfusion of Sequential Cytotoxic Nanoparticles to Enhance Chemotherapy Efficacy against Pancreatic Cancer

open access: yesAdvanced Science, 2022
Pancreatic ductal adenocarcinoma (PDAC), one of the worst prognosis types of tumors, is characterized by dense extracellular matrix, which compresses tumor vessels and forms a physical barrier to inhibit therapeutic drug penetration and efficacy. Herein,
Suchen Bian   +12 more
doaj   +1 more source

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