Results 21 to 30 of about 28,228 (226)

Losartan Alleviates Renal Fibrosis and Inhibits Endothelial-to-Mesenchymal Transition (EMT) Under High-Fat Diet-Induced Hyperglycemia

Frontiers in Pharmacology, 2018
The endothelial-to-mesenchymal transition (EMT) of glomerular vascular endothelial cells is considered to be pivotal in diabetic nephropathy (DN).
Yufeng Yao, Yong Li, Xiaofei Zeng, Zheng Ye, Xia Li, Lu Zhang   +5 more
doaj   +1 more source

Losartan Treatment Could Improve the Outcome of TBI Mice

Frontiers in Neurology, 2020
Traumatic brain injury frequently leads to serious mortality and physical disability, yet effective treatments remains insufficient. TBI always leads to a series of secondary brain injuries including neuronal apoptosis, continuous inflammation ...
Jianhua Xiong, Yalong Gao, Xiaotian Li, Kai Li, Qifeng Li, Jun Shen, Zhenying Han, Jianning Zhang   +7 more
doaj   +1 more source

Angiotensin II Type 1 Receptor Antagonist Losartan Inhibits TNF-α-Induced Inflammation and Degeneration Processes in Human Nucleus Pulposus Cells

Applied Sciences, 2021
Our recent study detected the expression of a tissue renin–angiotensin system (tRAS) in human intervertebral discs (IVDs). The present study sought to investigate the impact of the angiotensin II receptor type 1 (AGTR1) antagonist losartan on human ...
Babak Saravi, Zhen Li, Judith Pfannkuche, Laura Wystrach, Sonja Häckel, Christoph E. Albers, Sibylle Grad, Mauro Alini, Robert Geoffrey Richards, Corinna Lang, Norbert Südkamp, Hagen Schmal, Gernot Lang   +12 more
doaj   +1 more source

Losartan, an antihypertensive drug [PDF]

Acta Crystallographica Section E Structure Reports Online, 2004
The title compound, 2-butyl-4-chloro-1-[2′-(2H-tetrazol-5-yl)-1,1′-bi­phenyl-4-yl­methyl]-1H-imidazole-5-methanol, C22H23ClN6O, was precisely characterized at ca. 110 K, revealing a perfectly ordered structure (as opposed to earlier determinations) stabilized by intermolecular O—H⋯N and N—H⋯N hydrogen bonding.
Limor Tessler, Israel Goldberg
openaire   +1 more source

Dissociation between the circulating renin-angiotensin system and angiotensin II receptors in central losartan-induced hypertension

Brazilian Journal of Medical and Biological Research, 2002
Losartan, an AT1 angiotensin II (ANG II) receptor non-peptide antagonist, induces an increase in mean arterial pressure (MAP) when injected intracerebroventricularly (icv) into rats.
A.M. Sugawara, R.C. Vendramini, S.P. Barbosa, I.L. Brunetti, J.V. Menani, L.A. De Luca Jr.   +5 more
doaj   +1 more source

Effects of losartan combined with exercise training in spontaneously hypertensive rats

Brazilian Journal of Medical and Biological Research, 2003
We investigate whether combined treatment with losartan, an angiotensin II receptor blocker, and exercise training (ET) in spontaneously hypertensive rats (SHR) would have an additive effect in reducing hypertension and improving baroreflex sensitivity ...
L.F. Azevedo, P.C. Brum, K.C. Mattos, C.M. Junqueira, M.U.P.B. Rondon, A.C.P. Barretto, C.E. Negrao   +6 more
doaj   +1 more source

Antihypertension Nanoblockers Increase Intratumoral Perfusion of Sequential Cytotoxic Nanoparticles to Enhance Chemotherapy Efficacy against Pancreatic Cancer

Advanced Science, 2022
Pancreatic ductal adenocarcinoma (PDAC), one of the worst prognosis types of tumors, is characterized by dense extracellular matrix, which compresses tumor vessels and forms a physical barrier to inhibit therapeutic drug penetration and efficacy. Herein,
Suchen Bian, Haijiang Dong, Long Zhao, Zequn Li, Jian Chen, Xingxin Zhu, Nasha Qiu, Xing Jia, Wenfeng Song, Zekuan Li, Shusen Zheng, Hangxiang Wang, Penghong Song   +12 more
doaj   +1 more source

Different initiatives across Europe to enhance losartan utilisation post generics: impact and implications

Frontiers in Pharmacology, 2014
Introduction: There is an urgent need for health authorities across Europe to fully realise potential savings from increased use of generics to sustain their healthcare systems.
James eMoon, Brian eGodman, Brian eGodman, Max ePetzold, Samantha eAlvarez-Madrazo, Kathleen eBennett, Iain eBishop, Anna eBucsics, Ulrik eHesse, Andrew eMartin, Steven eSimoens, Corinne eZara, Rickard E Malmstrom   +12 more
doaj   +1 more source

Expert Approaches to the Assessment of Losartan Drugs Bioequivalence

Регуляторные исследования и экспертиза лекарственных средств, 2020
Angiotensin II receptor antagonists (ARAs) are one of the most promising classes of antihypertensive drugs. They are most widely represented on the Russian market by losartan drugs which total 24 items.
D. P. Romodanovsky, D. V. Goryachev
doaj   +1 more source

Angiotensin II-Type I Receptor Antagonism Does Not Influence the Chemoreceptor Reflex or Hypoxia-Induced Central Sleep Apnea in Men

Frontiers in Neuroscience, 2020
Components of the renin-angiotensin system (RAS) situated within the carotid body or central nervous system may promote hypoxia-induced chemoreceptor reflex sensitization or central sleep apnea (CSA).
Courtney V. Brown, Lindsey M. Boulet, Tyler D. Vermeulen, Scott A. Sands, Richard J. A. Wilson, Najib T. Ayas, Najib T. Ayas, John S. Floras, Glen E. Foster   +8 more
doaj   +1 more source