Results 31 to 40 of about 58,845 (265)

Effects of oral losartan administration on homeostasis of articular cartilage and bone in a rabbit model

Bone Reports, 2022
Background and aims: Previous work has shown that oral losartan can enhance microfracture-mediated cartilage repair in a rabbit osteochondral defect injury model.
Zhenhan Deng, Xueqin Gao, Hajime Utsunomiya, Justin W. Arner, Joseph J. Ruzbarsky, Matthieu Huard, Sudheer Ravuri, Marc J. Philippon, Johnny Huard   +8 more
doaj   +1 more source

Angiotensin II blockade and aortic-root dilation in Marfan's syndrome [PDF]

, 2008
Background: Progressive enlargement of the aortic root, leading to dissection, is the main cause of premature death in patients with Marfan's syndrome. Recent data from mouse models of Marfan's syndrome suggest that aortic-root enlargement is caused by ...
Brooke, Benjamin S., Dietz, Harry C., Habashi, Jennifer P., Judge, Daniel P., Loeys, Bart, Patel, Nishant   +5 more
core   +2 more sources

Losartan Treatment Could Improve the Outcome of TBI Mice

Frontiers in Neurology, 2020
Traumatic brain injury frequently leads to serious mortality and physical disability, yet effective treatments remains insufficient. TBI always leads to a series of secondary brain injuries including neuronal apoptosis, continuous inflammation ...
Jianhua Xiong, Yalong Gao, Xiaotian Li, Kai Li, Qifeng Li, Jun Shen, Zhenying Han, Jianning Zhang   +7 more
doaj   +1 more source

Neuroprotective Effect of Losartan after Traumatic Brain Injury in Male Rats Based on Marmarou Model

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2022
Background and Objective: Traumatic brain injury is the most important cause of death among young people in the world. Considering the neuroprotective effect of losartan on the recovery of brain damage, the present study was conducted to investigate the ...
Sh Shadi, A Siahposht-Khachaki, Gh Hooshmand   +2 more
doaj  

An Intact Kidney Slice Model to Investigate Vasa Recta Properties and Function in situ [PDF]

, 2012
Background: Medullary blood flow is via vasa recta capillaries, which possess contractile pericytes. In vitro studies using isolated descending vasa recta show that pericytes can constrict/dilate descending vasa recta when vasoactive substances are ...
Agmon Y, Armulik A, Bogle RG, Bratosin D, C. Crawford, C. Sprott, C.M. Peppiatt-Wildman, Crawford C, Cupples WA, Dahlstrom A, Dietrich HH, Dunn KW, Hall AM, Hamilton NB, Holliger C, Horiuchi T, Hughes S, J. Munday, Jans D, Kawamura H, L. Sawbridge, Landis EM, MacPhee PJ, Mattson DL, Mattson DL, O’Connor PM, Pallone TL, Pallone TL, Pallone TL, Pallone TL, Pallone TL, Park F, Patzak A, Peppiatt CM, Praetorius HA, R.J. Unwin, Rhinehart K, Rhinehart KL, Roman RJ, S.S.P. Wildman, Shepro D, Silldorff EP, Silldorff EP, Silldorff EP, Sprague RS, T. Desai, T. Kennedy-Lydon, Thiel G, Whitehouse T, Wu DM, Zhang Z, Zhang Z   +51 more
core   +2 more sources

Searching for New Leads to Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents [PDF]

, 2018
The purpose of this investigation is to contribute to the development of new anticonvulsant drugs to treat patients with refractory epilepsy. We applied a virtual screening protocol that involved the search into molecular databases of new compounds and ...
Bruno Blanch, Luis Enrique, Enrique, Nicolás Jorge, Gavernet, Luciana, Goicoechea, Sofia, Martín, Pedro, Milesi, Verónica, Palestro, Pablo Hernán, Sabatier, Laureano Leonel, Villalba, Maria Luisa   +8 more
core   +2 more sources

Angiotensin II Type 1 Receptor Antagonist Losartan Inhibits TNF-α-Induced Inflammation and Degeneration Processes in Human Nucleus Pulposus Cells

Applied Sciences, 2021
Our recent study detected the expression of a tissue renin–angiotensin system (tRAS) in human intervertebral discs (IVDs). The present study sought to investigate the impact of the angiotensin II receptor type 1 (AGTR1) antagonist losartan on human ...
Babak Saravi, Zhen Li, Judith Pfannkuche, Laura Wystrach, Sonja Häckel, Christoph E. Albers, Sibylle Grad, Mauro Alini, Robert Geoffrey Richards, Corinna Lang, Norbert Südkamp, Hagen Schmal, Gernot Lang   +12 more
doaj   +1 more source

Pharmacological effects of raas blockade in ischemic nephropathy [PDF]

, 2016
Background: The management of ischemic nephropathy due to atherosclerotic renal artery stenosis has become increasingly conservative in the modern era, with current guidelines recommending optimized medical therapy as the initial step.
Barbano, Biagio, Cianci, Rosario, Coppolino, Giuseppe, Di Mario, Francesca, Farrah, Tariq E., Fuiano, Giorgio, Gigante, Antonietta, Rivoli, Laura, Rosato, Edoardo   +8 more
core   +1 more source

Losartan Monotherapy vs Combination Regimens in IgA Nephropathy: A Systematic Review and Network Meta-analysis

ASIDE Internal Medicine
Background: IgA nephropathy (IgAN) is a disorder in which Immunoglobulin A (IgA) antibodies build up, causing kidney damage. Losartan, an Angiotensin Receptor Blocker (ARB), has shown promise in patients with IgAN. However, a comparison of losartan with
Mohamed E. Haseeb, Hazem E. Mohammed, Anas Hussein Heiba, George Hanen, Nada Ali Omar Abd Elaziz, Mohamed Nasser   +5 more
doaj   +1 more source

Effects of losartan combined with exercise training in spontaneously hypertensive rats

Brazilian Journal of Medical and Biological Research, 2003
We investigate whether combined treatment with losartan, an angiotensin II receptor blocker, and exercise training (ET) in spontaneously hypertensive rats (SHR) would have an additive effect in reducing hypertension and improving baroreflex sensitivity ...
L.F. Azevedo, P.C. Brum, K.C. Mattos, C.M. Junqueira, M.U.P.B. Rondon, A.C.P. Barretto, C.E. Negrao   +6 more
doaj   +1 more source