Results 31 to 40 of about 42,220 (210)

Losartan potassium

Definitions, 2020
T he potassium salt of losartan, a non-peptide angiotensin II receptor antagonist with antihypertensive activity. Losartan selectively and competitively binds to the angiotensin II receptor (type AT 1) and blocks the binding of angiotensin II to the ...
Losartan Potassium, B. Warning
semanticscholar   +1 more source

Losartan attenuates neuroinflammation and neuropathic pain in paclitaxel‐induced peripheral neuropathy

Journal of Cellular and Molecular Medicine, 2020
Paclitaxel‐induced peripheral neuropathy (PIPN) is often associated with neuropathic pain and neuroinflammation in the central and peripheral nervous system.
N. Kalynovska, M. Diallo, Dita Sotáková-Kašparová, J. Palecek   +3 more
semanticscholar   +1 more source

Neuroprotective Effect of Losartan after Traumatic Brain Injury in Male Rats Based on Marmarou Model

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2022
Background and Objective: Traumatic brain injury is the most important cause of death among young people in the world. Considering the neuroprotective effect of losartan on the recovery of brain damage, the present study was conducted to investigate the ...
Sh Shadi, A Siahposht-Khachaki, Gh Hooshmand   +2 more
doaj  

Losartan Treatment Could Improve the Outcome of TBI Mice

Frontiers in Neurology, 2020
Traumatic brain injury frequently leads to serious mortality and physical disability, yet effective treatments remains insufficient. TBI always leads to a series of secondary brain injuries including neuronal apoptosis, continuous inflammation ...
Jianhua Xiong, Yalong Gao, Xiaotian Li, Kai Li, Qifeng Li, Jun Shen, Zhenying Han, Jianning Zhang   +7 more
doaj   +1 more source

Angiotensin II Type 1 Receptor Antagonist Losartan Inhibits TNF-α-Induced Inflammation and Degeneration Processes in Human Nucleus Pulposus Cells

Applied Sciences, 2021
Our recent study detected the expression of a tissue renin–angiotensin system (tRAS) in human intervertebral discs (IVDs). The present study sought to investigate the impact of the angiotensin II receptor type 1 (AGTR1) antagonist losartan on human ...
Babak Saravi, Zhen Li, Judith Pfannkuche, Laura Wystrach, Sonja Häckel, Christoph E. Albers, Sibylle Grad, Mauro Alini, Robert Geoffrey Richards, Corinna Lang, Norbert Südkamp, Hagen Schmal, Gernot Lang   +12 more
doaj   +1 more source

Losartan Monotherapy vs Combination Regimens in IgA Nephropathy: A Systematic Review and Network Meta-analysis

ASIDE Internal Medicine
Background: IgA nephropathy (IgAN) is a disorder in which Immunoglobulin A (IgA) antibodies build up, causing kidney damage. Losartan, an Angiotensin Receptor Blocker (ARB), has shown promise in patients with IgAN. However, a comparison of losartan with
Mohamed E. Haseeb, Hazem E. Mohammed, Anas Hussein Heiba, George Hanen, Nada Ali Omar Abd Elaziz, Mohamed Nasser   +5 more
doaj   +1 more source

Effects of losartan combined with exercise training in spontaneously hypertensive rats

Brazilian Journal of Medical and Biological Research, 2003
We investigate whether combined treatment with losartan, an angiotensin II receptor blocker, and exercise training (ET) in spontaneously hypertensive rats (SHR) would have an additive effect in reducing hypertension and improving baroreflex sensitivity ...
L.F. Azevedo, P.C. Brum, K.C. Mattos, C.M. Junqueira, M.U.P.B. Rondon, A.C.P. Barretto, C.E. Negrao   +6 more
doaj   +1 more source

Different initiatives across Europe to enhance losartan utilisation post generics: impact and implications

Frontiers in Pharmacology, 2014
Introduction: There is an urgent need for health authorities across Europe to fully realise potential savings from increased use of generics to sustain their healthcare systems.
James eMoon, Brian eGodman, Brian eGodman, Max ePetzold, Samantha eAlvarez-Madrazo, Kathleen eBennett, Iain eBishop, Anna eBucsics, Ulrik eHesse, Andrew eMartin, Steven eSimoens, Corinne eZara, Rickard E Malmstrom   +12 more
doaj   +1 more source

Angiotensin II-Type I Receptor Antagonism Does Not Influence the Chemoreceptor Reflex or Hypoxia-Induced Central Sleep Apnea in Men

Frontiers in Neuroscience, 2020
Components of the renin-angiotensin system (RAS) situated within the carotid body or central nervous system may promote hypoxia-induced chemoreceptor reflex sensitization or central sleep apnea (CSA).
Courtney V. Brown, Lindsey M. Boulet, Tyler D. Vermeulen, Scott A. Sands, Richard J. A. Wilson, Najib T. Ayas, Najib T. Ayas, John S. Floras, Glen E. Foster   +8 more
doaj   +1 more source

Dissociation between the circulating renin-angiotensin system and angiotensin II receptors in central losartan-induced hypertension

Brazilian Journal of Medical and Biological Research, 2002
Losartan, an AT1 angiotensin II (ANG II) receptor non-peptide antagonist, induces an increase in mean arterial pressure (MAP) when injected intracerebroventricularly (icv) into rats.
A.M. Sugawara, R.C. Vendramini, S.P. Barbosa, I.L. Brunetti, J.V. Menani, L.A. De Luca Jr.   +5 more
doaj   +1 more source