Results 41 to 50 of about 73,633 (314)
Searching for New Leads to Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents [PDF]
, 2018 The purpose of this investigation is to contribute to the development of new anticonvulsant drugs to treat patients with refractory epilepsy. We applied a virtual screening protocol that involved the search into molecular databases of new compounds and ...
Bruno Blanch, Luis Enrique +8 more
core +2 more sources
Losartan Treatment Could Improve the Outcome of TBI Mice
Frontiers in Neurology, 2020 Traumatic brain injury frequently leads to serious mortality and physical disability, yet effective treatments remains insufficient. TBI always leads to a series of secondary brain injuries including neuronal apoptosis, continuous inflammation ...
Jianhua Xiong +7 more
doaj +1 more source
Advanced Science, 2022 Pancreatic ductal adenocarcinoma (PDAC), one of the worst prognosis types of tumors, is characterized by dense extracellular matrix, which compresses tumor vessels and forms a physical barrier to inhibit therapeutic drug penetration and efficacy. Herein,
Suchen Bian +12 more
doaj +1 more source
Angiotensin II blockade and aortic-root dilation in Marfan's syndrome [PDF]
, 2008 Background: Progressive enlargement of the aortic root, leading to dissection, is the main cause of premature death in patients with Marfan's syndrome. Recent data from mouse models of Marfan's syndrome suggest that aortic-root enlargement is caused by ...
Brooke, Benjamin S. +5 more
core +2 more sources
Contemporary Clinical Trials Communications, 2022 Objectives: To assess the efficacy and safety of losartan for COVID-19 patients. Methods: COVIDMED was a double-blinded, placebo-controlled platform RCT.
Daniel Freilich +3 more
doaj
Brazilian Journal of Medical and Biological Research, 2002 Losartan, an AT1 angiotensin II (ANG II) receptor non-peptide antagonist, induces an increase in mean arterial pressure (MAP) when injected intracerebroventricularly (icv) into rats.
A.M. Sugawara +5 more
doaj +1 more source
Applied Sciences, 2021 Our recent study detected the expression of a tissue renin–angiotensin system (tRAS) in human intervertebral discs (IVDs). The present study sought to investigate the impact of the angiotensin II receptor type 1 (AGTR1) antagonist losartan on human ...
Babak Saravi +12 more
doaj +1 more source
An Intact Kidney Slice Model to Investigate Vasa Recta Properties and Function in situ [PDF]
, 2012 Background: Medullary blood flow is via vasa recta capillaries, which possess contractile pericytes. In vitro studies using isolated descending vasa recta show that pericytes can constrict/dilate descending vasa recta when vasoactive substances are ...
Agmon Y +51 more
core +2 more sources
Losartan, an antihypertensive drug [PDF]
Acta Crystallographica Section E Structure Reports Online, 2004 The title compound, 2-butyl-4-chloro-1-[2′-(2H-tetrazol-5-yl)-1,1′-biphenyl-4-ylmethyl]-1H-imidazole-5-methanol, C22H23ClN6O, was precisely characterized at ca. 110 K, revealing a perfectly ordered structure (as opposed to earlier determinations) stabilized by intermolecular O—H⋯N and N—H⋯N hydrogen bonding.
Limor Tessler, Israel Goldberg
openaire +1 more source
Angiotensin-(1-7) increases osmotic water permeability in isolated toad skin [PDF]
, 2000 Angiotensin-(1-7) (Ang-(1-7)) increased osmotic water permeability in the isolated toad skin, a tissue with functional properties similar to those of the distal mammalian nephron. Concentrations of 0.1 to 10 μM were effective, with a peak at 20 min. This
Coviello, Alfredo +3 more
core +4 more sources