Results 41 to 50 of about 58,845 (265)

Drug treatment of hypertension: focus on vascular health [PDF]

, 2016
Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C., Lang, Ninian N., Touyz, Rhian M.   +2 more
core   +1 more source

Losartan Alleviates Renal Fibrosis and Inhibits Endothelial-to-Mesenchymal Transition (EMT) Under High-Fat Diet-Induced Hyperglycemia

Frontiers in Pharmacology, 2018
The endothelial-to-mesenchymal transition (EMT) of glomerular vascular endothelial cells is considered to be pivotal in diabetic nephropathy (DN).
Yufeng Yao, Yong Li, Xiaofei Zeng, Zheng Ye, Xia Li, Lu Zhang   +5 more
doaj   +1 more source

The role of urate and xanthine oxidase in vascular oxidative stress:Future directions [PDF]

, 2009
Vascular oxidative stress has been shown to be a potent factor in the pathophysiology of endothelial dysfunction. Despite current optimal evidence-based therapy, mortality from various cardiovascular disorders remains high.
George, Jacob, Struthers, Allan
core   +5 more sources

Different initiatives across Europe to enhance losartan utilisation post generics: impact and implications

Frontiers in Pharmacology, 2014
Introduction: There is an urgent need for health authorities across Europe to fully realise potential savings from increased use of generics to sustain their healthcare systems.
James eMoon, Brian eGodman, Brian eGodman, Max ePetzold, Samantha eAlvarez-Madrazo, Kathleen eBennett, Iain eBishop, Anna eBucsics, Ulrik eHesse, Andrew eMartin, Steven eSimoens, Corinne eZara, Rickard E Malmstrom   +12 more
doaj   +1 more source

Angiotensin II-Type I Receptor Antagonism Does Not Influence the Chemoreceptor Reflex or Hypoxia-Induced Central Sleep Apnea in Men

Frontiers in Neuroscience, 2020
Components of the renin-angiotensin system (RAS) situated within the carotid body or central nervous system may promote hypoxia-induced chemoreceptor reflex sensitization or central sleep apnea (CSA).
Courtney V. Brown, Lindsey M. Boulet, Tyler D. Vermeulen, Scott A. Sands, Richard J. A. Wilson, Najib T. Ayas, Najib T. Ayas, John S. Floras, Glen E. Foster   +8 more
doaj   +1 more source

Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function [PDF]

, 2014
<b>Objective:</b><p></p> Mitochondria-derived reactive oxygen species (ROS) play important roles in the development of cardiovascular disease highlighting the need for novel targeted therapies.
Adlam, Cai, Calhoun, Chacko, Chandran, DAgostino, Dai, Dai, Dikalova, Doughan, Evans, Flores-Munoz, Flores-Munoz, Gane, Graham, Graham, Gutierrez, Halliwell, Jalil, Jeffs, Landmesser, London, Lowes, Mercer, Messerli, Murphy, Murphy, Nakagami, Nakamura, Nozoe, Qin, Rajagopalan, Roman, Ross, Snow, Watkins, Winterbourn, Yang, Yasunari, Zhang, Zhang, Zorov   +41 more
core   +1 more source

Losartan protects against osteoarthritis by repressing the TGF-β1 signaling pathway via upregulation of PPARγ

Journal of Orthopaedic Translation, 2021
Objective: Losartan and activation of the peroxisome proliferator-activated receptor-γ (PPARγ) have been previously reported to alleviate the progression of osteoarthritis (OA).
Zhenhan Deng, MD, Ph.D, Fei Chen, Ph.D, Yuwei Liu, MD, Ph.D, Jinping Wang, Ph.D, Wei Lu, MD, Ph.D, Wei Jiang, MD, Ph.D, Weimin Zhu, MD, Ph.D   +6 more
doaj   +1 more source

Pitfalls in blood pressure measurement in daily practice [PDF]

, 2006
Background. Accurate blood pressure (BP) readings and correctly interpreting the obtained values are of great importance. However, there is considerable variation in the different BP measuring methods suggested in guidelines and used in hypertension ...
Bilo, H.J.G., Groenier, K.H., Houweling, S.T., Kleefstra, N., Lutgers, H.L., Meyboom-de Jong, B.   +5 more
core   +2 more sources

Data on the effects of losartan on protein expression, vascular reactivity and antioxidant capacity in the aorta of ethanol-treated rats

Data in Brief, 2017
We describe the effects of losartan, a selective AT1 receptor antagonist on the alterations induced by treatment with ethanol in the rat aorta. The data shown here are related to the article entitled “Angiotensin type 1 receptor mediates chronic ethanol ...
Carla S. Ceron, Gabriel T. do Vale, Janaina A. Simplicio, Patrícia Passaglia, Sthefany T. Ricci, Carlos R. Tirapelli   +5 more
doaj   +1 more source

Repurposing drugs to target nonalcoholic steatohepatitis [PDF]

, 2019
Nonalcoholic fatty liver disease (NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage.
Pirola, Carlos José, Sookoian, Silvia Cristina   +1 more
core   +1 more source