Study Protocol for a Prospective, Unicentric, Double-Blind, Randomized, and Placebo-Controlled Trial on the Efficacy of a Low-Histamine Diet and DAO Enzyme Supplementation in Patients with Histamine Intolerance [PDF]
Background/Objectives: Histamine intolerance is primarily caused by a deficiency in the diamine oxidase (DAO) enzyme at the intestinal level. The reduced histamine degradation in the gut leads to its accumulation in plasma, thereby causing multiple clinical manifestations, such as urticaria, diarrhea, headache, dyspnea, or tachycardia, among others ...
Adriana Duelo +16 more
core +5 more sources
Abstract Background/Objectives Quantification of diamine oxidase (DAO) concentrations in serum has been proposed as an adjunctive diagnostic modality for the evaluation of histamine intolerance (HIT).
Georgios Rentzos +3 more
openaire +3 more sources
A case series of diamine oxidase deficiency misdiagnosed as anxiety or panic attacks in patients with tachycardia [PDF]
Background: Diamine oxidase (DAO) deficiency, a key marker of histamine intolerance (HIT), often mimics anxiety or panic disorders, leading to a misdiagnoses and delayed treatment.
Ilkay Keskinel
doaj +2 more sources
Targeting Soluble VCAM1 and GSK3β Improves Cerebrovascular Function and Reduces Stroke Pathology in Diabetic Mice [PDF]
Type 2 diabetes (T2D) features insulin resistance that promotes cerebrovascular injury, yet the immune signals linking metabolic stress to vascular dysfunction remain unclear.
Masuma Akter Brishti +4 more
doaj +2 more sources
The role of exogenous histamine in atopic dermatitis flare-ups
Atopic dermatitis (AD) remains a significant challenge due to its chronic and relapsing nature, with various triggers exacerbating symptoms. While endogenous histamine’s role in AD is well documented, the impact of exogenous histamine remains ...
Zofia Kowalska, Joanna Narbutt
doaj +2 more sources
Effects of dietary fiber on the gut microbiota, intestinal barrier, and inflammatory factors in Xinjiang black pigs [PDF]
Background Alfalfa meal is rich in insoluble dietary fiber and bioactive compounds, which undergo fermentation in the hindgut of pigs. Its metabolites are closely associated with intestinal barrier function and immune responses.
ZhenXin Zhu +7 more
doaj +2 more sources
Inhibition of mTOR is the standard of care for lymphangioleiomyomatosis (LAM). However, this therapy has variable tolerability and some patients show progressive decline of lung function despite treatment.
Carmen Herranz +56 more
doaj +1 more source
Oxidized low-density lipoprotein contributes to atherogenesis via co-activation of macrophages and mast cells. [PDF]
Oxidized low-density lipoprotein (OxLDL) is a risk factor for atherosclerosis, due to its role in endothelial dysfunction and foam cell formation. Tissue-resident cells such as macrophages and mast cells release inflammatory mediators upon activation ...
Chong Chen, Damir B Khismatullin
doaj +1 more source
Microbiological properties, proximate composition, total volatile base nitrogen (TVB-N), pH, fatty acid (FA) composition, peroxide value (PV), free fatty acids (FFA), histamine and water holding capacity (WHC) in fresh and frozen-stored (3, 6, and 12 ...
Foroud Yadollahi +3 more
doaj +1 more source
Granuloma pouch and skin histamine of the rat [PDF]
Using the granuloma pouch technique of SELYE, effect of modification in local histamine on the inflammatory tissue reactions was examined in rats. The increase in the weight of pouch wall and histological inflammatory changes were distinctly inhibited in
Irino, Shozo
core +1 more source

